• Advertisement

Archive for the ‘antimigraine agents’ Category

Wigraine

Posted by admin on November 3rd, 2009

Wigraine

Generic Name: caffeine and ergotamine (oral/rectal) (KAF een and er GOT a meen)

What is caffeine and ergotamine?

Caffeine is a stimulant that causes narrowing of blood vessels (vasoconstriction).

Ergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain. Ergotamine also affects blood flow patterns that are associated with certain types of headaches.

The combination of caffeine and ergotamine is used to treat or prevent a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Caffeine and ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Caffeine and ergotamine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about caffeine and ergotamine?

This medication can harm an unborn baby or a nursing baby. Do not use caffeine and ergotamine if you are pregnant or breast-feeding. Do not use this medication if you are allergic to caffeine and ergotamine or other ergot medicines, or if you have a history of heart disease, angina (chest pain), blood circulation problems, history of a heart attack or stroke, coronary artery disease, uncontrolled high blood pressure, severe liver or kidney disease, or a serious infection. Using certain medications together with caffeine and ergotamine can cause even greater decreases in blood flow than caffeine and ergotamine used alone. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects. Tell your doctor about all other medications you are using, especially antibiotics, antidepressants, heart or blood pressure medications, or medicines to treat HIV or AIDS.

Also tell your doctor about all of your medical conditions, especially breathing problems, high blood pressure, liver or kidney disease, or risk factors for coronary artery disease (diabetes, high blood pressure or cholesterol, menopause or hysterectomy, smoking, taking birth control pills, being overweight, having a family history of coronary artery disease, or being a man older than 40).

This medication will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Never use more than your prescribed dose of caffeine and ergotamine. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. An overdose of caffeine and ergotamine can be fatal.

What should I discuss with my healthcare provider before using caffeine and ergotamine ?

Do not use this medication if you are allergic to caffeine or ergotamine, or other ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), methylergonovine (Methergine), or methysergide (Sansert).

Do not use caffeine and ergotamine if you are pregnant or breast-feeding, or if you have:

a history of heart disease, angina (chest pain), blood circulation problems, or history of a heart attack or stroke;

coronary artery disease or “hardening of the arteries”;

uncontrolled high blood pressure;

a serious infection called sepsis.

conivaptan (Vaprisol);

diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);

imatinib (Gleevec);

isoniazid (for treating tuberculosis);

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), telithromycin (Ketek), or troleandomycin (Tao);

an antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

an antidepressant such as nefazodone;

heart or blood pressure medication such as diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), quinidine (Quinaglute, Quinidex, Quin-Release), or verapamil (Calan, Covera, Isoptin, Verelan); or

HIV/AIDS medicine such as amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase, Fortovase), or ritonavir (Norvir).

Caffeine and ergotamine can cause rare but serious side effects on the heart, including heart attack or stroke. If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using caffeine and ergotamine, tell your doctor if you have:

breathing problems;

high blood pressure;

liver disease;

kidney disease; or

coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

How should I use caffeine and ergotamine?

Use this medication exactly as prescribed by your doctor. Never use more than your prescribed dose of caffeine and ergotamine. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Caffeine and ergotamine is not for daily use.

To use caffeine and ergotamine tablets: Take 2 tablets of caffeine and ergotamine as soon as you notice headache symptoms, or after an attack has already begun.

If your headache does not completely go away, you may take 1 more tablet after at least 30 minutes have passed. If additional medication is needed, you may take 1 tablet every 30 minutes up to a total of 6 tablets for one migraine attack.

If you still have migraine symptoms after taking a total of 6 tablets, call your doctor. Do not take more than a total of 6 tablets in any 24-hour period. Do not take more than a total of 10 tablets over a period of 7 days.

To use caffeine and ergotamine rectal suppositories: Insert 1 suppository at the first sign of migraine headache symptoms, or after an attack has already begun. If your headache does not completely go away, use 1 more suppository after at least 1 hour has passed.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Try to empty your bladder just before using the suppository. Remove the outer wrapper from the suppository and insert it gently into the rectum, pointed tip first. Avoid handling the suppository too long or it will melt in your hands.

For best results, lie down after inserting the suppository and hold it in for a few minutes. The suppository will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after you have inserted the suppository.

If you still have migraine symptoms after using a total of 2 rectal suppositories, call your doctor. Do not use more than a total of 2 suppositories per headache. Do not use more than a total of 5 suppositories over a period of 7 days. Do not give this medication to anyone else, even if they have the same headache symptoms you have. Caffeine and ergotamine can be dangerous if it is used to treat headache in a person who has not been diagnosed by a doctor as having true migraine headaches. Store caffeine and ergotamine at room temperature away from moisture, heat, and light. Do not use any stored caffeine and ergotamine if the expiration date on the label has passed.

What happens if I miss a dose?

Since caffeine and ergotamine is used only when needed, you are not likely to miss a dose.

Do not take more than 6 caffeine and ergotamine tablets per day or more than 10 tablets per week. Do not use more than 2 suppositories per headache or 5 suppositories per week.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of caffeine and ergotamine can be fatal.

Overdose can cause vomiting, confusion, drowsiness, weak pulses in your arms and legs, numbness and tingling or pain in your hands or feet, blue-colored fingers or toes, fainting, and seizure (convulsions).

What should I avoid while using caffeine and ergotamine?

Do not use caffeine and ergotamine within 24 hours before or after using another migraine headache medicine, including:

dihydroergotamine (D.H.E. 45, Migranal), caffeine and ergotamine (Cafergot, Ercaf, Wigraine), ergonovine (Ergotrate), methylergonovine (Methergine), methysergide (Sansert); or

almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), sumatriptan (Imitrex), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig).

Grapefruit and grapefruit juice may interact with caffeine and ergotamine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Caffeine and ergotamine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using caffeine and ergotamine and call your doctor at once if you have a serious side effect such as:

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

fast or slow heart rate;

muscle pain in your arms or legs;

leg weakness;

numbness or tingling and a pale or blue-colored appearance in your fingers or toes;

severe pain in your stomach or lower back;

urinating less than usual or not at all;

painful sores on your rectum after using the rectal suppositories;

swelling or itching in any part of your body;

cough with stabbing chest pain and trouble breathing; or

dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

dizziness, spinning sensation;

weakness;

nausea, vomiting; or

mild itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect caffeine and ergotamine?

Many drugs can interact with caffeine and ergotamine. Below is just a partial list. Talk with your doctor before using caffeine and ergotamine if you are also taking:

birth control pills;

zileuton (Zyflo);

cold or allergy medications;

nicotine (Nicoderm, Nicorette);

diet pills, stimulants, or medication to treat ADHD (such as Ritalin or Adderall);

an antidepressant such fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), nefazodone (Serzone), paroxetine (Paxil), sertraline (Zoloft), and others;

nitroglycerin or other nitrate medicines such as isosorbide (Isordil, Dilatrate, Imdur, Monoket); or

heart or blood pressure medication such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

This list is not complete and there may be other drugs that can interact with caffeine and ergotamine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Posted in antimigraine agents Tags: , No Comments »

Sumavel DosePro

Posted by admin on November 3rd, 2009

Sumavel DosePro

Generic Name: sumatriptan

FDA Approves Sumavel DosePro

The U.S. Food and Drug Administration (FDA) has approved Sumavel DosePro (sumatriptan injection) needle-free delivery system to treat acute migraine, with or without aura, and cluster headache. Sumavel DosePro is a first-of-its-kind needle-free delivery system for subcutaneous sumatriptan, a treatment that provides migraine relief within 10 minutes for some patients.

The FDA approval of Sumavel DosePro is based on extensive efficacy and safety data from original filings for needle-based sumatriptan injection (Imitrex), in addition to clinical studies conducted by Zogenix on bioequivalence, usability and safety specific to the Sumavel DosePro combination drug/needle-free delivery system.

About Sumavel DosePro

Sumavel DosePro (sumatriptan injection) needle-free delivery system is indicated for the acute treatment of migraine attacks, with or without aura, and the acute treatment of cluster headache episodes.

Sumavel DosePro should only be used where a clear diagnosis of migraine or cluster headache has been established. Sumavel DosePro is not intended for the prophylactic therapy of migraine or for use in the management of hemiplegic or basilar migraine and should not be administered intravenously. For a given attack, if a patient does not respond to the first dose of Sumavel DosePro, the diagnosis of migraine or cluster headache should be reconsidered before administration of a second dose.

Important Safety Information

Sumavel DosePro is contraindicated in patients with ischemic heart disease or those with symptoms consistent with ischemic heart disease. It should not be administered to patients with cerebrovascular syndromes, peripheral vascular disease or in patients with uncontrolled hypertension. Very rarely, serious cardiac adverse events have been reported when taking sumatriptan, including patients with no findings of cardiovascular disease. Considering the extent of use of sumatriptan in patients with migraine, the incidence of these events is extremely low.

Sumavel DosePro should not be used within 24 hours of other ergotamine-containing or ergot-type medications or other 5-HT1 agonists and is not generally recommended for use with selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors SNRIs or MAO inhibitors. Sumavel DosePro should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

The most common adverse events observed in controlled clinical trials with sumatriptan injection were injection site reactions, atypical sensations (such as feelings of tingling, warm/hot sensations), dizziness and flushing. Most side effects lasted for only a short time. In clinical trials comparing the safety and tolerability of Sumavel DosePro to sumatriptan injection, most injection site reactions resolved spontaneously, with no apparent difference between Sumavel DosePro and sumatriptan needle injection.

About DosePro technology

The DosePro technology is an easy-to-use, pre-filled drug delivery system designed to enable self-administration of single doses of liquid drug formulations, subcutaneously, without a needle. The DosePro technology has undergone more than ten years of design, process engineering, clinical evaluation and development work. DosePro is protected by more than 80 patents, issued and applied for, worldwide. Approximately 9,000 injections have been delivered in clinical trials in healthy volunteers using the DosePro needle-free drug delivery system.

Sumavel DosePro Patient Information

Read the Patient Information that comes with Sumavel DosePro before you start taking it and each time you get a refill. There may be new information. This leaflet does not take the place of talking with your doctor about your medical condition or treatment. You and your doctor should talk about Sumavel DosePro when you start taking it and at regular checkups.

What is the most important information I should know about Sumavel DosePro?

In very rare cases, patients taking triptans, such as Sumavel DosePro, may experience serious side effects, including heart attacks. Call your doctor right away if you have:

Sumavel DosePro is not for people with risk factors for heart disease unless a heart exam is done and shows no problem. You have a higher risk for heart disease if you:

“Serotonin syndrome” is a serious and life-threatening problem that can happen with Sumavel DosePro, especially if used with anti-depressant medicines called selective serotonin reuptake inhibitors (SSRIs) or selective norepinephrine reuptake inhibitors (SNRIs). Ask your doctor or pharmacist for a list of these medicines if you are not sure.

Call your doctor if you have any of these symptoms of serotonin syndrome:

What is Sumavel DosePro?

Sumavel DosePro is a prescription medicine given with a needle-free delivery system to treat people who have been diagnosed with migraine or cluster headaches.

Sumavel DosePro is not used to prevent or lessen the number of migraine or cluster headache attacks you have.

Sumavel DosePro is not used to treat other types of headaches.

It is not known if Sumavel DosePro is safe or effective in people younger than 18 years of age.

Who should not take Sumavel DosePro?

Do not take Sumavel DosePro if you have:

What should I tell my doctor before taking Sumavel DosePro?

Before taking Sumavel DosePro, tell your doctor about all of your medical conditions, including if you:

Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Using Sumavel DosePro with certain other medicines can affect each other causing serious side effects.

Especially tell your doctor if you take anti-depressant medicines called:

Ask your doctor or pharmacist for a list of these medicines if you are not sure.

How should I take Sumavel DosePro?

What are the possible side effects of Sumavel DosePro?

Sumavel DosePro can cause serious side effects including death. See “What is the most important information I should know about Sumavel DosePro?”

Serious side effects include:

Get medical help right away, if you have:

The most common side effects of Sumavel DosePro include:

Tell your doctor if you have any side effect that bothers you or that does not go away. These are not all the possible side effects of Sumavel DosePro. For more information, ask your doctor or pharmacist.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Sumavel DosePro?

Keep Sumavel DosePro and all medicines out of the reach of children.

General information about Sumavel DosePro

Medicines are sometimes prescribed for purposes other than those listed in patient information leaflets. Do not use Sumavel DosePro for a condition for which it was not prescribed. Do not give Sumavel DosePro to other people, even if they have the same symptoms that you have. It may harm them. This patient information leaflet summarizes the most important information about Sumavel DosePro. If you would like more information about Sumavel DosePro, talk to your doctor. You can ask your doctor or pharmacist for information about Sumavel DosePro that is written for health professionals.

For more information, go to www.SumavelDosePro.com or call 1-866-ZOGENIX.

What are the Ingredients in Sumavel DosePro?

Patient Instructions for Use

Read these Patient Instructions for Use which come with Sumavel DosePro before you start using it and each time you get a refill. Follow these instructions each time you use Sumavel DosePro. Before you use Sumavel DosePro for the first time, make sure your healthcare provider shows you the right way to use it.

A. Check your device:

The snap-off tip should sit firmly on the end of the clear medication chamber. Do not use Sumavel DosePro if the snap-off tip is tilted or broken off. The medicine inside Sumavel DosePro should be clear and colorless or pale yellow. Do not use Sumavel DosePro if the medicine looks dark-colored or cloudy. The expiration date is printed on both the Sumavel DosePro label and carton. Do not use Sumavel DosePro if the medicine is expired.

B. Choose a delivery site:

Select a delivery site such as your stomach area (abdomen) or your thigh. Do not deliver Sumavel DosePro in the arm. Your skin should be clean, and dry, and free of clothing. Do not deliver through your clothes. Do not deliver into scars or moles, or within 2 inches of your belly button (navel). Do not deliver into the same spot. Change delivery sites with each use.

After removing Sumavel DosePro from your skin, gently wipe the delivery site with a cotton ball or gauze.

More Sumavel DosePro resources

Posted in antimigraine agents Tags: , No Comments »

Migrin-A

Posted by admin on November 3rd, 2009

Migrin-A

Generic Name: isometheptene, dichloralphenazone, and acetaminophen (Oral route)

eye-soe-meth-EP-teen MUE-kate, dye-klor-al-FEN-a-zone, a-seet-a-MIN-oh-fen

Commonly used brand name(s):

Available Dosage Forms:

Therapeutic Class: Acetaminophen Combination

Pharmacologic Class: Isometheptene

Uses For Migrin-A

Isometheptene, dichloralphenazone, and acetaminophen combination is used to treat certain kinds of headaches, such as “tension” headaches and migraine headaches. This combination is not used regularly (for example, every day) to prevent headaches. It should be taken only after headache pain begins, or after a warning sign that a migraine is coming appears. Isometheptene helps to relieve throbbing headaches, but it is not an ordinary pain reliever. Dichloralphenazone helps you to relax, and acetaminophen relieves pain.

This medicine is available only with your doctor’s prescription.

Before Using Migrin-A

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies with this medicine have been done only in adult patients, and there is no specific information about its use in children.

Geriatric

Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this combination medicine in the elderly with use in other age groups.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of isometheptene, dichloralphenazone, and acetaminophen

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often than directed, and do not take it every day for several days in a row. If the amount you are to take does not relieve your headache, check with your doctor. If a headache medicine is used too often, it may lose its effectiveness or even cause a type of physical dependence. If this occurs, your headaches may actually get worse. Also, taking too much acetaminophen can cause liver damage.

This medicine works best if you:

People who get a lot of headaches may need to take a different medicine to help prevent headaches. It is important that you follow your doctor’s directions, even if your headaches continue to occur. Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headaches should occur less often, and they should be less severe and easier to relieve, than before. This will reduce the amount of headache relievers that you need. If you do not notice any improvement after several weeks of headache-preventing treatment, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Precautions While Using Migrin-A

Check with your doctor:

Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take. Taking other medicines that contain acetaminophen together with this medicine may lead to an overdose. If you have any questions about this, check with your health care professional.

This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. These effects may be especially severe if you also take CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness) together with this medicine. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; antiemetics (medicines that prevent or relieve nausea or vomiting), and anesthetics. If you are not able to lie down for a while, make sure you know how you react to this medicine or combination of medicines before you drive, use machines, or do anything else that could be dangerous if you are drowsy or dizzy or are not alert.

Do not drink alcoholic beverages while taking this medicine. To do so may increase the chance of liver damage caused by acetaminophen, especially if you drink large amounts of alcoholic beverages regularly. Also, because drinking alcoholic beverages may make your headaches worse or cause new headaches to occur, people who often get headaches should probably avoid alcohol.

Migrin-A Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

More Migrin-A resources

Compare Migrin-A with other medications for the treatment of:

Posted in antimigraine agents Tags: , No Comments »

Migrazone

Posted by admin on November 3rd, 2009

Migrazone

Generic Name: acetaminophen, dichloralphenazone, and isometheptene (a seet a MIN oh fen, dye klor al PHEN a zone, and eye so meh THEP teen)

What is Migrazone (acetaminophen, dichloralphenazone, and isometheptene)?

Acetaminophen is a pain reliever and a fever reducer.

Dichloralphenazone is a sedative that slows down your central nervous system (brain and nerve impulses), causing relaxation and pain relief.

Isometheptene causes constriction (narrowing) of blood vessels (arteries and veins). This is important in the treatment of headaches.

The combination, acetaminophen, dichloralphenazone, and isometheptene, is used to treat tension (or muscle contraction) and vascular (migraine) headaches.

Acetaminophen, dichloralphenazone, and isometheptene may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Migrazone (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

What should I discuss with my healthcare provider before taking Migrazone (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease. You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose. Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Before taking this medication, tell your doctor if you have

glaucoma;

high blood pressure or heart disease; or

poor circulation.

You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether acetaminophen, dichloralphenazone, and isometheptene will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether acetaminophen, dichloralphenazone, and isometheptene will harm a breast-feeding baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Migrazone (acetaminophen, dichloralphenazone, and isometheptene)?

Take acetaminophen, dichloralphenazone, and isometheptene exactly as directed by your doctor or follow the instructions on the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Do not share this medication with anyone else.

Store this medication at room temperature away from heat, moisture, and the reach of children.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

If you are taking acetaminophen, dichloralphenazone, and isometheptene on an as-needed basis, missing a dose is not usually a problem. Take the missed dose as soon as you remember and do not take another dose for the amount of time prescribed by your doctor.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an acetaminophen, dichloralphenazone, and isometheptene overdose are unknown but drowsiness and dizziness would be expected.

What should I avoid while taking Migrazone (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

Migrazone (acetaminophen, dichloralphenazone, and isometheptene) side effects

If you experience any of the following serious side effects, stop taking acetaminophen, dichloralphenazone, and isometheptene and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

liver damage (yellowing of the skin or eyes, abdominal pain); or

blood problems (easy or unusual bleeding or bruising).

These side effects are very rare and are not likely to occur during proper treatment with acetaminophen, dichloralphenazone, and isometheptene.

Other, less serious side effects may be more likely to occur. Continue to take acetaminophen, dichloralphenazone, and isometheptene and talk to your doctor if you experience

nausea;

dizziness, tiredness, or lightheadedness; or

a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Migrazone (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Dichloralphenazone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Many other medicines contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications. Too much acetaminophen can be very dangerous.

Drugs other than those listed here may also interact with acetaminophen, dichloralphenazone, and isometheptene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Posted in antimigraine agents Tags: , No Comments »

Migratine

Posted by admin on November 3rd, 2009

Migratine

Generic Name: acetaminophen, dichloralphenazone, and isometheptene (a seet a MIN oh fen, dye klor al PHEN a zone, and eye so meh THEP teen)

What is Migratine (acetaminophen, dichloralphenazone, and isometheptene)?

Acetaminophen is a pain reliever and a fever reducer.

Dichloralphenazone is a sedative that slows down your central nervous system (brain and nerve impulses), causing relaxation and pain relief.

Isometheptene causes constriction (narrowing) of blood vessels (arteries and veins). This is important in the treatment of headaches.

The combination, acetaminophen, dichloralphenazone, and isometheptene, is used to treat tension (or muscle contraction) and vascular (migraine) headaches.

Acetaminophen, dichloralphenazone, and isometheptene may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Migratine (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

What should I discuss with my healthcare provider before taking Migratine (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease. You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose. Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Before taking this medication, tell your doctor if you have

glaucoma;

high blood pressure or heart disease; or

poor circulation.

You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether acetaminophen, dichloralphenazone, and isometheptene will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether acetaminophen, dichloralphenazone, and isometheptene will harm a breast-feeding baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Migratine (acetaminophen, dichloralphenazone, and isometheptene)?

Take acetaminophen, dichloralphenazone, and isometheptene exactly as directed by your doctor or follow the instructions on the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Do not share this medication with anyone else.

Store this medication at room temperature away from heat, moisture, and the reach of children.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

If you are taking acetaminophen, dichloralphenazone, and isometheptene on an as-needed basis, missing a dose is not usually a problem. Take the missed dose as soon as you remember and do not take another dose for the amount of time prescribed by your doctor.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an acetaminophen, dichloralphenazone, and isometheptene overdose are unknown but drowsiness and dizziness would be expected.

What should I avoid while taking Migratine (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

Migratine (acetaminophen, dichloralphenazone, and isometheptene) side effects

If you experience any of the following serious side effects, stop taking acetaminophen, dichloralphenazone, and isometheptene and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

liver damage (yellowing of the skin or eyes, abdominal pain); or

blood problems (easy or unusual bleeding or bruising).

These side effects are very rare and are not likely to occur during proper treatment with acetaminophen, dichloralphenazone, and isometheptene.

Other, less serious side effects may be more likely to occur. Continue to take acetaminophen, dichloralphenazone, and isometheptene and talk to your doctor if you experience

nausea;

dizziness, tiredness, or lightheadedness; or

a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Migratine (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Dichloralphenazone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Many other medicines contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications. Too much acetaminophen can be very dangerous.

Drugs other than those listed here may also interact with acetaminophen, dichloralphenazone, and isometheptene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Posted in antimigraine agents Tags: , No Comments »

Migquin

Posted by admin on November 3rd, 2009

Migquin

Generic Name: acetaminophen, dichloralphenazone, and isometheptene (a seet a MIN oh fen, dye klor al PHEN a zone, and eye so meh THEP teen)

What is Migquin (acetaminophen, dichloralphenazone, and isometheptene)?

Acetaminophen is a pain reliever and a fever reducer.

Dichloralphenazone is a sedative that slows down your central nervous system (brain and nerve impulses), causing relaxation and pain relief.

Isometheptene causes constriction (narrowing) of blood vessels (arteries and veins). This is important in the treatment of headaches.

The combination, acetaminophen, dichloralphenazone, and isometheptene, is used to treat tension (or muscle contraction) and vascular (migraine) headaches.

Acetaminophen, dichloralphenazone, and isometheptene may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Migquin (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

What should I discuss with my healthcare provider before taking Migquin (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease. You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose. Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Before taking this medication, tell your doctor if you have

glaucoma;

high blood pressure or heart disease; or

poor circulation.

You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether acetaminophen, dichloralphenazone, and isometheptene will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether acetaminophen, dichloralphenazone, and isometheptene will harm a breast-feeding baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Migquin (acetaminophen, dichloralphenazone, and isometheptene)?

Take acetaminophen, dichloralphenazone, and isometheptene exactly as directed by your doctor or follow the instructions on the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Do not share this medication with anyone else.

Store this medication at room temperature away from heat, moisture, and the reach of children.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

If you are taking acetaminophen, dichloralphenazone, and isometheptene on an as-needed basis, missing a dose is not usually a problem. Take the missed dose as soon as you remember and do not take another dose for the amount of time prescribed by your doctor.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an acetaminophen, dichloralphenazone, and isometheptene overdose are unknown but drowsiness and dizziness would be expected.

What should I avoid while taking Migquin (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

Migquin (acetaminophen, dichloralphenazone, and isometheptene) side effects

If you experience any of the following serious side effects, stop taking acetaminophen, dichloralphenazone, and isometheptene and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

liver damage (yellowing of the skin or eyes, abdominal pain); or

blood problems (easy or unusual bleeding or bruising).

These side effects are very rare and are not likely to occur during proper treatment with acetaminophen, dichloralphenazone, and isometheptene.

Other, less serious side effects may be more likely to occur. Continue to take acetaminophen, dichloralphenazone, and isometheptene and talk to your doctor if you experience

nausea;

dizziness, tiredness, or lightheadedness; or

a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Migquin (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Dichloralphenazone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Many other medicines contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications. Too much acetaminophen can be very dangerous.

Drugs other than those listed here may also interact with acetaminophen, dichloralphenazone, and isometheptene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Posted in antimigraine agents Tags: , No Comments »

Migergot

Posted by admin on November 3rd, 2009

Migergot Suppositories

Serious and sometimes life-threatening decreases in the blood supply to the extremities (eg, hands, feet) or brain may occur if Migergot Suppositories are taken with certain other medicines, including HIV protease inhibitors (eg, ritonavir) and macrolide antibiotics (eg, erythromycin). Do not use Migergot Suppositories if you are also taking these other medicines. Inform your doctor of all the medicines that you are taking.

Migergot Suppositories are used for:

Preventing and treating certain kinds of headaches (eg, migraines, migraine variants, “histaminic cephalalgia”). It may also be used for other conditions as determined by your doctor.

Migergot Suppositories are a combination of 2 vasoconstrictors. It works by constricting blood vessels in the lining of the brain, which helps to decrease the pain from migraine headaches.

Do NOT use Migergot Suppositories if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Migergot Suppositories:

Some medical conditions may interact with Migergot Suppositories. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Migergot Suppositories. Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Migergot Suppositories may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Migergot Suppositories:

Use Migergot Suppositories as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Migergot Suppositories.

Important safety information:

When used for long periods of time or at high doses, some people develop a need to continue taking Migergot Suppositories. This is known as DEPENDENCE or addiction. It is important that you take Migergot Suppositories as instructed by your doctor. Migergot Suppositories are not for long-term daily use.

Possible side effects of Migergot Suppositories:

All medicines may cause side effects, but many people have no, or minor, side effects.

Nausea.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blue color of the fingers or toes; chest pain or tightness; cold or pale fingers or toes; diarrhea; dizziness; hallucinations; headache; irregular heartbeat; leg cramps or weakness; mental or mood changes; muscle pain; numbness or tingling of the hands, feet, or skin; rectal sores; ringing in the ears; seizure; severe or persistent nausea or vomiting; shortness of breath; swelling; temporary fast or slow heartbeat; vomiting; weak pulse.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Migergot Suppositories in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Migergot Suppositories out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Migergot Suppositories. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Migergot Suppositories resources

Compare Migergot Suppositories with other medications for the treatment of:

Posted in antimigraine agents Tags: , No Comments »

Isocom

Posted by admin on November 3rd, 2009

Isocom

Generic Name: acetaminophen, dichloralphenazone, and isometheptene (a seet a MIN oh fen, dye klor al PHEN a zone, and eye so meh THEP teen)

What is Isocom (acetaminophen, dichloralphenazone, and isometheptene)?

Acetaminophen is a pain reliever and a fever reducer.

Dichloralphenazone is a sedative that slows down your central nervous system (brain and nerve impulses), causing relaxation and pain relief.

Isometheptene causes constriction (narrowing) of blood vessels (arteries and veins). This is important in the treatment of headaches.

The combination, acetaminophen, dichloralphenazone, and isometheptene, is used to treat tension (or muscle contraction) and vascular (migraine) headaches.

Acetaminophen, dichloralphenazone, and isometheptene may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Isocom (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

What should I discuss with my healthcare provider before taking Isocom (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene without first talking to your doctor if you drink more than three alcoholic beverages per day or if you have had alcoholic liver disease. You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose. Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Before taking this medication, tell your doctor if you have

glaucoma;

high blood pressure or heart disease; or

poor circulation.

You may not be able to take acetaminophen, dichloralphenazone, and isometheptene, or you may require a lower dose or special monitoring during treatment if you have any of the conditions listed above.

It is not known whether acetaminophen, dichloralphenazone, and isometheptene will harm an unborn baby. Do not take this medication without first talking to your doctor if you are pregnant. It is also not known whether acetaminophen, dichloralphenazone, and isometheptene will harm a breast-feeding baby. Do not take this medication without first talking to your doctor if you are breast-feeding a baby.

How should I take Isocom (acetaminophen, dichloralphenazone, and isometheptene)?

Take acetaminophen, dichloralphenazone, and isometheptene exactly as directed by your doctor or follow the instructions on the package. If you do not understand these instructions, ask your pharmacist, nurse, or doctor to explain them to you.

Take each dose with a full glass of water. Never take more acetaminophen, dichloralphenazone, and isometheptene than is prescribed for you. If your pain is not being adequately treated, talk to your doctor.

Do not share this medication with anyone else.

Store this medication at room temperature away from heat, moisture, and the reach of children.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Do not take a double dose of this medication. Wait the prescribed amount of time before taking your next dose.

If you are taking acetaminophen, dichloralphenazone, and isometheptene on an as-needed basis, missing a dose is not usually a problem. Take the missed dose as soon as you remember and do not take another dose for the amount of time prescribed by your doctor.

What happens if I overdose?

Seek emergency medical attention.

Symptoms of an acetaminophen, dichloralphenazone, and isometheptene overdose are unknown but drowsiness and dizziness would be expected.

What should I avoid while taking Isocom (acetaminophen, dichloralphenazone, and isometheptene)?

Use caution when driving, operating machinery, or performing other hazardous activities. Dichloralphenazone may cause drowsiness or dizziness. If you experience drowsiness or dizziness, avoid these activities. Avoid alcohol. Alcohol taken during therapy with acetaminophen, dichloralphenazone, and isometheptene can be very damaging to your liver and can increase drowsiness and dizziness.

Avoid other over-the-counter and prescription products that contain acetaminophen. Too much acetaminophen could be dangerous. Talk to your doctor or pharmacist before taking any over-the-counter preparations.

Isocom (acetaminophen, dichloralphenazone, and isometheptene) side effects

If you experience any of the following serious side effects, stop taking acetaminophen, dichloralphenazone, and isometheptene and seek emergency medical attention:

an allergic reaction (difficulty breathing; closing of your throat; swelling of your lips, tongue, or face; or hives);

liver damage (yellowing of the skin or eyes, abdominal pain); or

blood problems (easy or unusual bleeding or bruising).

These side effects are very rare and are not likely to occur during proper treatment with acetaminophen, dichloralphenazone, and isometheptene.

Other, less serious side effects may be more likely to occur. Continue to take acetaminophen, dichloralphenazone, and isometheptene and talk to your doctor if you experience

nausea;

dizziness, tiredness, or lightheadedness; or

a rash.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Isocom (acetaminophen, dichloralphenazone, and isometheptene)?

Do not take acetaminophen, dichloralphenazone, and isometheptene if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) in the last 14 days. Dangerous side effects could result.

Dichloralphenazone may increase the effects of other drugs that cause drowsiness, including antidepressants, alcohol, antihistamines, sedatives (used to treat insomnia), pain relievers, anxiety medicines, and muscle relaxants. Tell your doctor about all medicines that you are taking, and do not take any medicine unless your doctor approves.

Many other medicines contain acetaminophen, especially over-the-counter pain, fever, cold, and allergy medications. Too much acetaminophen can be very dangerous.

Drugs other than those listed here may also interact with acetaminophen, dichloralphenazone, and isometheptene. Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Posted in antimigraine agents Tags: , No Comments »

Iso-Acetazone

Posted by admin on November 3rd, 2009

Iso-Acetazone

Generic Name: isometheptene, dichloralphenazone, and acetaminophen (Oral route)

eye-soe-meth-EP-teen MUE-kate, dye-klor-al-FEN-a-zone, a-seet-a-MIN-oh-fen

Commonly used brand name(s):

Available Dosage Forms:

Therapeutic Class: Acetaminophen Combination

Pharmacologic Class: Isometheptene

Uses For Iso-Acetazone

Isometheptene, dichloralphenazone, and acetaminophen combination is used to treat certain kinds of headaches, such as “tension” headaches and migraine headaches. This combination is not used regularly (for example, every day) to prevent headaches. It should be taken only after headache pain begins, or after a warning sign that a migraine is coming appears. Isometheptene helps to relieve throbbing headaches, but it is not an ordinary pain reliever. Dichloralphenazone helps you to relax, and acetaminophen relieves pain.

This medicine is available only with your doctor’s prescription.

Before Using Iso-Acetazone

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Studies with this medicine have been done only in adult patients, and there is no specific information about its use in children.

Geriatric

Many medicines have not been tested in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of this combination medicine in the elderly with use in other age groups.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of isometheptene, dichloralphenazone, and acetaminophen

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often than directed, and do not take it every day for several days in a row. If the amount you are to take does not relieve your headache, check with your doctor. If a headache medicine is used too often, it may lose its effectiveness or even cause a type of physical dependence. If this occurs, your headaches may actually get worse. Also, taking too much acetaminophen can cause liver damage.

This medicine works best if you:

People who get a lot of headaches may need to take a different medicine to help prevent headaches. It is important that you follow your doctor’s directions, even if your headaches continue to occur. Headache-preventing medicines may take several weeks to start working. Even after they do start working, your headaches may not go away completely. However, your headaches should occur less often, and they should be less severe and easier to relieve, than before. This will reduce the amount of headache relievers that you need. If you do not notice any improvement after several weeks of headache-preventing treatment, check with your doctor.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Precautions While Using Iso-Acetazone

Check with your doctor:

Check the labels of all nonprescription (over-the-counter [OTC]) and prescription medicines you now take. Taking other medicines that contain acetaminophen together with this medicine may lead to an overdose. If you have any questions about this, check with your health care professional.

This medicine may cause some people to become drowsy, dizzy, or less alert than they are normally. These effects may be especially severe if you also take CNS depressants (medicines that slow down the nervous system, possibly causing drowsiness) together with this medicine. Some examples of CNS depressants are antihistamines or medicine for hay fever, other allergies, or colds; sedatives, tranquilizers, or sleeping medicine; prescription pain medicine or narcotics; barbiturates; medicine for seizures; muscle relaxants; antiemetics (medicines that prevent or relieve nausea or vomiting), and anesthetics. If you are not able to lie down for a while, make sure you know how you react to this medicine or combination of medicines before you drive, use machines, or do anything else that could be dangerous if you are drowsy or dizzy or are not alert.

Do not drink alcoholic beverages while taking this medicine. To do so may increase the chance of liver damage caused by acetaminophen, especially if you drink large amounts of alcoholic beverages regularly. Also, because drinking alcoholic beverages may make your headaches worse or cause new headaches to occur, people who often get headaches should probably avoid alcohol.

Iso-Acetazone Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

More Iso-Acetazone resources

Compare Iso-Acetazone with other medications for the treatment of:

Posted in antimigraine agents Tags: , No Comments »

Ercaf

Posted by admin on November 3rd, 2009

Ercaf

Generic Name: caffeine and ergotamine (oral/rectal) (KAF een and er GOT a meen)

What is caffeine and ergotamine?

Caffeine is a stimulant that causes narrowing of blood vessels (vasoconstriction).

Ergotamine is in a group of drugs called ergot alkaloids (ER-got AL-ka-loids). It works by narrowing the blood vessels around the brain. Ergotamine also affects blood flow patterns that are associated with certain types of headaches.

The combination of caffeine and ergotamine is used to treat or prevent a migraine type headache.

This medication will only treat a headache that has already begun. It will not prevent migraine headaches or reduce the number of attacks.

Caffeine and ergotamine should not be used to treat common tension headaches or any headache that seems to be different from your usual migraine headaches.

Caffeine and ergotamine may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about caffeine and ergotamine?

This medication can harm an unborn baby or a nursing baby. Do not use caffeine and ergotamine if you are pregnant or breast-feeding. Do not use this medication if you are allergic to caffeine and ergotamine or other ergot medicines, or if you have a history of heart disease, angina (chest pain), blood circulation problems, history of a heart attack or stroke, coronary artery disease, uncontrolled high blood pressure, severe liver or kidney disease, or a serious infection. Using certain medications together with caffeine and ergotamine can cause even greater decreases in blood flow than caffeine and ergotamine used alone. A severe decrease in blood flow to the brain and other parts of the body can lead to dangerous side effects. Tell your doctor about all other medications you are using, especially antibiotics, antidepressants, heart or blood pressure medications, or medicines to treat HIV or AIDS.

Also tell your doctor about all of your medical conditions, especially breathing problems, high blood pressure, liver or kidney disease, or risk factors for coronary artery disease (diabetes, high blood pressure or cholesterol, menopause or hysterectomy, smoking, taking birth control pills, being overweight, having a family history of coronary artery disease, or being a man older than 40).

This medication will only treat a headache that has already begun. It will not prevent headaches or reduce the number of attacks.

Never use more than your prescribed dose of caffeine and ergotamine. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. An overdose of caffeine and ergotamine can be fatal.

What should I discuss with my healthcare provider before using caffeine and ergotamine ?

Do not use this medication if you are allergic to caffeine or ergotamine, or other ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), methylergonovine (Methergine), or methysergide (Sansert).

Do not use caffeine and ergotamine if you are pregnant or breast-feeding, or if you have:

a history of heart disease, angina (chest pain), blood circulation problems, or history of a heart attack or stroke;

coronary artery disease or “hardening of the arteries”;

uncontrolled high blood pressure;

a serious infection called sepsis.

conivaptan (Vaprisol);

diclofenac (Arthrotec, Cataflam, Voltaren, Flector Patch, Solareze);

imatinib (Gleevec);

isoniazid (for treating tuberculosis);

an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), telithromycin (Ketek), or troleandomycin (Tao);

an antifungal medication such as clotrimazole (Mycelex Troche), itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

an antidepressant such as nefazodone;

heart or blood pressure medication such as diltiazem (Cardizem, Dilacor, Tiazac), nicardipine (Cardene), quinidine (Quinaglute, Quinidex, Quin-Release), or verapamil (Calan, Covera, Isoptin, Verelan); or

HIV/AIDS medicine such as amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase, Fortovase), or ritonavir (Norvir).

Caffeine and ergotamine can cause rare but serious side effects on the heart, including heart attack or stroke. If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using caffeine and ergotamine, tell your doctor if you have:

breathing problems;

high blood pressure;

liver disease;

kidney disease; or

coronary artery disease (or risk factors that include diabetes, menopause, smoking, being overweight, having high blood pressure or high cholesterol, having a family history of coronary artery disease, being older than 40 and a man, or being a woman who has had a hysterectomy).

How should I use caffeine and ergotamine?

Use this medication exactly as prescribed by your doctor. Never use more than your prescribed dose of caffeine and ergotamine. Follow the directions on your prescription label. Tell your doctor if the medicine seems to stop working as well in treating your migraine attacks. Caffeine and ergotamine is not for daily use.

To use caffeine and ergotamine tablets: Take 2 tablets of caffeine and ergotamine as soon as you notice headache symptoms, or after an attack has already begun.

If your headache does not completely go away, you may take 1 more tablet after at least 30 minutes have passed. If additional medication is needed, you may take 1 tablet every 30 minutes up to a total of 6 tablets for one migraine attack.

If you still have migraine symptoms after taking a total of 6 tablets, call your doctor. Do not take more than a total of 6 tablets in any 24-hour period. Do not take more than a total of 10 tablets over a period of 7 days.

To use caffeine and ergotamine rectal suppositories: Insert 1 suppository at the first sign of migraine headache symptoms, or after an attack has already begun. If your headache does not completely go away, use 1 more suppository after at least 1 hour has passed.

Do not take a rectal suppository by mouth. It is for use only in your rectum.

Try to empty your bladder just before using the suppository. Remove the outer wrapper from the suppository and insert it gently into the rectum, pointed tip first. Avoid handling the suppository too long or it will melt in your hands.

For best results, lie down after inserting the suppository and hold it in for a few minutes. The suppository will melt quickly once inserted and you should feel little or no discomfort while holding it in. Avoid using the bathroom just after you have inserted the suppository.

If you still have migraine symptoms after using a total of 2 rectal suppositories, call your doctor. Do not use more than a total of 2 suppositories per headache. Do not use more than a total of 5 suppositories over a period of 7 days. Do not give this medication to anyone else, even if they have the same headache symptoms you have. Caffeine and ergotamine can be dangerous if it is used to treat headache in a person who has not been diagnosed by a doctor as having true migraine headaches. Store caffeine and ergotamine at room temperature away from moisture, heat, and light. Do not use any stored caffeine and ergotamine if the expiration date on the label has passed.

What happens if I miss a dose?

Since caffeine and ergotamine is used only when needed, you are not likely to miss a dose.

Do not take more than 6 caffeine and ergotamine tablets per day or more than 10 tablets per week. Do not use more than 2 suppositories per headache or 5 suppositories per week.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. An overdose of caffeine and ergotamine can be fatal.

Overdose can cause vomiting, confusion, drowsiness, weak pulses in your arms and legs, numbness and tingling or pain in your hands or feet, blue-colored fingers or toes, fainting, and seizure (convulsions).

What should I avoid while using caffeine and ergotamine?

Do not use caffeine and ergotamine within 24 hours before or after using another migraine headache medicine, including:

dihydroergotamine (D.H.E. 45, Migranal), caffeine and ergotamine (Cafergot, Ercaf, Wigraine), ergonovine (Ergotrate), methylergonovine (Methergine), methysergide (Sansert); or

almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), sumatriptan (Imitrex), rizatriptan (Maxalt, Maxalt-MLT), or zolmitriptan (Zomig).

Grapefruit and grapefruit juice may interact with caffeine and ergotamine and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

Caffeine and ergotamine side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using caffeine and ergotamine and call your doctor at once if you have a serious side effect such as:

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

fast or slow heart rate;

muscle pain in your arms or legs;

leg weakness;

numbness or tingling and a pale or blue-colored appearance in your fingers or toes;

severe pain in your stomach or lower back;

urinating less than usual or not at all;

painful sores on your rectum after using the rectal suppositories;

swelling or itching in any part of your body;

cough with stabbing chest pain and trouble breathing; or

dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

Less serious side effects may include:

dizziness, spinning sensation;

weakness;

nausea, vomiting; or

mild itching.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect caffeine and ergotamine?

Many drugs can interact with caffeine and ergotamine. Below is just a partial list. Talk with your doctor before using caffeine and ergotamine if you are also taking:

birth control pills;

zileuton (Zyflo);

cold or allergy medications;

nicotine (Nicoderm, Nicorette);

diet pills, stimulants, or medication to treat ADHD (such as Ritalin or Adderall);

an antidepressant such fluoxetine (Prozac, Sarafem), fluvoxamine (Luvox), nefazodone (Serzone), paroxetine (Paxil), sertraline (Zoloft), and others;

nitroglycerin or other nitrate medicines such as isosorbide (Isordil, Dilatrate, Imdur, Monoket); or

heart or blood pressure medication such as atenolol (Tenormin), carvedilol (Coreg), labetalol (Normodyne, Trandate), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal, InnoPran), sotalol (Betapace), and others.

This list is not complete and there may be other drugs that can interact with caffeine and ergotamine. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Posted in antimigraine agents Tags: , No Comments »
« Older Entries
Free T-Mobile phones on sale | Thanks to Best Savings Accounts, Conveyancing Fees and Used Cars