Archive for the ‘vasodilators’ Category

Prostin VR Pediatric

Prostin VR Pediatric

Generic Name: alprostadil (injectable and transurethral) (al PROS ta dil)

What is alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

Alprostadil relaxes blood vessels and muscles in the penis. This increases blood flow into the penis, causing an erection.

Alprostadil may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about alprostadil?

Alprostadil is used to treat erectile dysfunction (impotence) and to help diagnose certain causes of this disorder. Alprostadil is also used to improve blood flow in newborn babies with a certain genetic heart condition. This alprostadil medication guide addresses only the adult male use of this medication in erectile disorders.

The injectable form of alprostadil is injected into the side of the penis. The transurethral form is a very small suppository (pellet) that is inserted into the opening of the penis (the urethra).

Use this medication exactly as it was prescribed for you. Using too much alprostadil can be very dangerous. This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Your first dose of this medicine will be given in your doctor’s office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself.

Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different from these averages.

Seek emergency medical attention if you think you have used too much of this medication. Symptoms of an alprostadil overdose may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I discuss with my healthcare provider before using alprostadil?

Do not use alprostadil if you have:

sickle cell anemia or the sickle cell anemia trait;

leukemia;

a tumor of the bone marrow (multiple myeloma);

chronic urination problems;

a history of blood clots;

a curved or deformed penis;

penile fibrosis or Peyronie’s disease; or

if you have been told you should not have sexual intercourse for health reasons.

Before using alprostadil, tell your doctor if you have:

a bleeding or blood-clotting disorder;

a disease that could be passed in blood (such as hepatitis or HIV);

heart disease;

high blood pressure (hypertension); or

if you have a penile implant.

If you have any of these conditions, you may need a dose adjustment or special tests to safely use this medication.

Use a condom to prevent transfer of this medication to your sexual partner if she is pregnant or could become pregnant.

Alprostadil should not be used by women or by anyone under 18 years old.

How should I use alprostadil?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Using too much alprostadil can be very dangerous.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

The injectable form of alprostadil is injected into the side of the penis. The transurethral form is a very small suppository (pellet) that is inserted into the opening of the penis (the urethra).

Your first dose of this medicine will be given in your doctor’s office so you can be observed for how well the medication works and if it causes any side effects. You will then be shown how to properly give the medication to yourself.

Do not give yourself an alprostadil injection or pellet if you do not understand the instructions for proper use. Call your doctor, nurse, or pharmacist for help with injection instructions. Using an alprostadil transurethral pellet improperly could cause damage to your urethra.

Alprostadil is used only when needed to get an erection. An erection should occur within 5 to 20 minutes after you use the medication, and should last for 30 to 60 minutes. The length of time your erection lasts may be slightly different from these averages.

To be sure this medication is not causing harmful effects, your penis will need to be examined on a regular basis. It is important that you not miss any scheduled appointments.

Alprostadil injectable is a powder medicine that comes with a sterile liquid for mixing it. Caverject Impulse is a brand of alprostadil injectable supplied as a needle and syringe that contains both the powder medicine and the sterile liquid. The dose is automatically mixed when you turn a dial on the end of the syringe. The Caverject Impulse syringe is designed for only one use. Carefully follow the instructions provided with this product.

Do not mix alprostadil injectable or draw your dose into a syringe until you are ready to give yourself an injection. Do not shake the mixed medication. After mixing, the medication should be clear, without any particles in it.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

The Caverject Impulse device uses a very thin needle, which could break easily. If the needle breaks during injection and you can see and grasp the broken end, remove it and contact your doctor. If you cannot remove the broken end, call your doctor right away.

An alprostadil injection can cause bleeding where the needle is placed. This can make it easier for your sexual partner to be exposed to your blood. Before using this medication, tell your doctor if you have a virus such as hepatitis or HIV, which can be passed to another person who comes into contact with your blood.

Do not use more than 2 alprostadil pellets in one day (24 hours). Do not use more than 3 alprostadil injections per week. Allow at least 24 hours to pass between injections.

Storing this medicine:

What happens if I miss a dose?

Since alprostadil is used as needed, you will not be on a dosing schedule.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medication. Overdose symptoms may include feeling light-headed, fainting, or having a painful or prolonged erection lasting 4 hours or longer.

What should I avoid while using alprostadil?

Alprostadil can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Alprostadil side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using alprostadil and call your doctor at once if you have any of these serious side effects:

feeling light-headed, fainting;

bleeding from your urethra;

bleeding, bruising, or swelling where you injected the medication;

a painful erection that lasts 4 hours or longer;

severe pain or irritation of your penis or urethra; or

redness, lumps, tenderness, unusual shape or curving of the erect penis.

Less serious side effects may include:

pain in your penis, urethra, or testicles;

headache, dizziness;

back pain;

a rash on the skin of your penis;

warmth or numbness of your penis; or

cough, stuffy nose, cold symptoms.

Your sexual partner may also experience side effects such as burning, itching, or irritation of the body areas that come into contact with your penis.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect alprostadil?

Before using alprostadil, tell your doctor if you are using any of the following drugs:

nitroglycerin;

hydralazine (BiDil); or

a blood thinner such as warfarin (Coumadin), heparin, dalteparin (Fragmin), danaparoid (Orgaran), or enoxaparin (Lovenox).

This list is not complete and here may be other drugs that can interact with alprostadil. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Nitrostat Tablets

Nitrostat Tablets

Why is Nitrostat Tablets prescribed?

Nitroglycerin is prescribed to prevent and treat angina pectoris (suffocating chest pain). This condition occurs when the coronary arteries become constricted and are not able to carry sufficient oxygen to the heart muscle. Nitroglycerin is thought to improve oxygen flow by relaxing the walls of arteries and veins, thus allowing them to dilate.

Nitroglycerin is used in different forms. As a patch or ointment, nitroglycerin may be applied to the skin. The patch and the ointment are for

Swallowing nitroglycerin in capsule or tablet form also helps to

In the form of sublingual (held under the tongue) or buccal (held in the cheek) tablets, or in oral spray (sprayed on or under the tongue), nitroglycerin helps relieve chest pain that has

Most important fact about Nitrostat Tablets

Nitroglycerin may cause severe low blood pressure (possibly marked by dizziness or light-headedness), especially if you are in an upright position or have just gotten up from sitting or lying down. You may also find your heart rate slowing and your chest pain increasing. People taking diuretic medication, or who have low systolic blood pressure (less than 90 mm Hg) should use nitroglycerin with caution.

How should you take Nitrostat Tablets?

Since nitroglycerin is available in many forms, it is crucial for you to follow your doctor’s directions for taking the type of nitroglycerin prescribed for you. Never interchange brands.

Ideally, you should take nitroglycerin while sitting down—especially if you feel dizzy or light-headed—so as to avoid a fall.

Avoid puncturing the spray container and keep it away from excess heat.

Do not open the container of sublingual tablets until you need a dose. Close the container tightly immediately after each use. Do not put other medications, a cotton plug, or anything else in the container. Keep the sublingual tablets handy at all times. Keep the patches in the protective pouches they come in until use.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking nitroglycerin.

Why should Nitrostat Tablets not be prescribed?

You should not be using nitroglycerin if you are allergic to it or to the adhesive in the patch, if you have a head injury, or if you have any condition caused by increased fluid pressure in your head. Nitroglycerin should not be taken if you have severe anemia or if you recently had a heart attack. The capsule form should not be used if you have closed-angle glaucoma (pressure in the eye) or suffer from postural hypotension (dizziness upon standing up). Do not take the tablets if you are using the impotence drug sildenafil.

Special warnings about Nitrostat Tablets

If your vision becomes blurry or your mouth becomes dry while taking nitroglycerin, it should be discontinued. Contact your doctor immediately if these symptoms develop.

You may develop acute headaches if you take nitroglycerin excessively. Also, some people may develop a tolerance to nitroglycerin, and it may become less beneficial over time, especially if used in excess.

Nitroglycerin tablets lose their effectiveness when exposed to air. If you are taking sublingual nitroglycerin, you may notice a burning or tingling sensation. This does not necessarily mean that tablets which have been exposed to air for a long period of time are still good.

Take no more than the smallest possible amount needed to relieve pain.

Daily headaches may be an indicator of the drug’s activity. Do not change your dose to avoid the headache, because you may reduce the drug’s effectiveness at the same time.

Before taking nitroglycerin, tell your doctor if you have had a recent heart attack, head injury, or stroke; or if you have anemia, glaucoma (pressure in the eye), or heart, kidney, liver, or thyroid disease.

If you use a patch, dispose of it carefully. There is enough drug left in a used patch to be harmful to children and pets.

Since nitroglycerin can cause dizziness, you should observe caution while driving, operating machinery, or performing other tasks that demand concentration.

The benefits of applying nitroglycerin to the skin of people experiencing heart attacks or congestive heart failure have not been established. If you are using the medication for these conditions, your doctor will monitor you to prevent low blood pressure and pounding heartbeat.

Possible food and drug interactions when taking Nitrostat Tablets

If nitroglycerin is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

Taken with many high blood pressure drugs, nitroglycerin may cause extreme low blood pressure (dizziness, fainting, numbness). Take particular care with calcium channel blockers such as nifedipine and verapamil, as well as isosorbide dinitrate, isosorbide mononitrate, blood vessel dilators such as minoxidil, and beta-blocker medications such as atenolol. Nitroglycerin may also cause a severe drop in blood pressure when taken with the impotence drug sildenafil.

Aspirin can increase the effects of nitroglycerin.

Alcohol may interact with nitroglycerin and cause a swift decrease in blood pressure, possibly causing dizziness and fainting.

Also be alert for an interaction with dihydroergotamine. Check with your doctor if you are uncertain about any combination you plan to take.

Special information if you are pregnant or breastfeeding

It has not been determined whether nitroglycerin might harm a fetus or a pregnant woman. As a result, nitroglycerin should be used only when the benefits of therapy clearly outweigh the potential risks to the fetus and woman. It is not known if nitroglycerin appears in breast milk; therefore, a nursing mother should use nitroglycerin only on advice of her doctor.

Recommended dosage for Nitrostat Tablets

The following section is intended to provide guidelines for taking nitroglycerin. Follow your doctor’s instructions carefully for using nitroglycerin in the form prescribed for you.

ADULTS

At the first sign of chest pain, 1 tablet should be dissolved under the tongue or inside the cheek. You may repeat the dose every 5 minutes until the pain is relieved. If your pain continues after you have taken 3 tablets in a 15-minute period, notify your doctor or seek medical attention immediately.

You may take sublingual or buccal nitroglycerin from 5 to 10 minutes before starting activities that may cause chest pain.

A patch is applied to the skin for 12 to 14 hours. After this time, the patch is removed; it is not applied again for 10 to 12 hours (a “patch-off” period). Apply the patch as soon as you remove it from its protective pouch.

At the first sign of chest pain, spray 1 or 2 pre-measured doses onto or under the tongue. You should not use more than 3 doses within a 15-minute period. If your chest pain continues, you should contact your doctor or seek medical attention immediately.

The spray can be used 5 to 10 minutes before activity that might precipitate an attack.

Your initial dose may be a daily total of 1 inch of ointment. Apply one-half inch on rising in the morning, and the remaining one-half inch 6 hours later. If needed, follow your doctor’s instructions for increasing your dosage. Apply in a thin, uniform layer, regardless of the amount of your dosage. There should be a daily period where no ointment is applied. Usually, the “ointment-off” period will last from 10 to 12 hours.

Absorption varies with site of application—more is absorbed through the chest.

The smallest effective amount should be taken 2 or 3 times a day at 8- to 12-hour intervals.

CHILDREN

The safety and effectiveness of nitroglycerin have not been established for children.

OLDER ADULTS

In general, dosages less than the above adult dosages are recommended, since the elderly may be more susceptible to low blood pressure and headaches.

Overdosage

Any medication taken in excess can have serious consequences. Severe overdosage of nitroglycerin may result in death. If you suspect an overdose, seek medical attention immediately.

More Nitrostat Tablets resources

Nitrostat

Nitrostat

Nitrostat is used for:

Preventing or relieving a sudden attack of angina (chest pain) caused by heart disease. It may also be used for other conditions as determined by your doctor.

Nitrostat is a nitrate. It works by dilating (widening) blood vessels. Chest pain occurs when the heart needs more oxygen than it can get. Dilating blood vessels allows blood to flow more easily. This reduces the heart’s workload and the amount of oxygen needed by the heart.

Do NOT use Nitrostat if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nitrostat :

Some medical conditions may interact with Nitrostat . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Nitrostat . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nitrostat may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nitrostat :

Use Nitrostat as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Nitrostat .

Important safety information:

When used at higher doses or more often than prescribed, Nitrostat may not work as well. This is known as TOLERANCE. Tolerance to other nitrates and nitrites may also occur. Increasing the dose is not effective in managing tolerance to Nitrostat . Talk with your doctor if Nitrostat stops working well. Do not take more than prescribed.

Possible side effects of Nitrostat :

All medicines may cause side effects, but many people have no, or minor, side effects.

Burning or tingling sensation; dizziness; headache; lightheadedness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; dry mouth; fainting; flushing; heavy sweating; irregular heartbeat; nausea; new or worsening chest pain; pale skin; pounding in the chest; severe dizziness or headache; shortness of breath; slow heartbeat; swelling of the hands, ankles, or feet; unusual weakness; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Nitrostat in the original container, tightly closed, at or below 77 degrees F (25 degrees C). Protect from heat, moisture, and light. Do not store in bathroom. Keep Nitrostat out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Nitrostat . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Nitrostat resources

Compare Nitrostat with other medications for the treatment of:

Nitropress

Nitropress

Generic Name: nitroprusside (nye troe PRUS ide)

What is Nitropress (nitroprusside)?

Nitroprusside is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries.

Nitroprusside is used to treat congestive heart failure and life-threatening high blood pressure (hypertension). Nitroprusside is also used to keep blood pressure low during a surgery.

Nitroprusside may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Nitropress (nitroprusside)?

You should not receive this medication if you are allergic to nitroprusside, or if you have hereditary vision loss (Leber’s disease), vision problems caused by smoking, or a history of blood clot in your brain.

Before receiving nitroprusside, tell your doctor if you have high blood pressure (hypertension), liver disease, anemia (a lack of red blood cells), a seizure disorder, or a history of head injury or brain tumor.

Seek emergency medical attention if you think you have received too much of this medicine.

Symptoms of a nitroprusside overdose may include nausea, vomiting, stomach pain, sweating, severe dizziness, headache, muscle twitching, fast or pounding heartbeat, restless feeling, and chest or back pain.

Tell your caregivers right away about any serious side effects such as breathing problems, tremors or chills, numbness or cold feeling in your hands or feet, easy bruising, unusual bleeding, muscle pain or weakness, confusion, feeling extremely light-headed, or fainting.

What should I discuss with my health care provider before receiving Nitropress (nitroprusside)?

You should not receive this medication if you are allergic to nitroprusside, or if you have:

hereditary vision loss (Leber’s disease);

vision problems caused by smoking; or

a history of blood clot in your brain.

Before receiving nitroprusside, tell your doctor if you are allergic to any drugs, or if you have:

high blood pressure (hypertension);

liver disease;

anemia (a lack of red blood cells);

epilepsy or other seizure disorder; or

a history of head injury or brain tumor.

If you have any of these conditions, you may not be able to receive nitroprusside, or you may need dosage adjustments or special tests during treatment.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Nitroprusside may pass into breast milk and could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

How should I take Nitropress (nitroprusside)?

Nitroprusside is given as an injection through a needle placed into a vein. An infusion pump is used to inject nitroprusside, to assure that you do not receive the medicine too quickly.

You will receive this injection in a clinic or hospital setting. Nitroprusside is usually given for as long as needed until your body responds to the medication.

To be sure nitroprusside is not causing harmful effects, your blood pressure will need to be checked during the entire time you are receiving this medication.

What happens if I miss a dose?

Since nitroprusside is usually given as needed in a hospital setting, it is not likely that you will miss a dose.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Symptoms of a nitroprusside overdose may include nausea, vomiting, stomach pain, sweating, severe dizziness, headache, muscle twitching, fast or pounding heartbeat, restless feeling, and chest or back pain.

What should I avoid while receiving Nitropress (nitroprusside)?

Follow your doctor’s instructions about any restrictions in food, beverages, activities, or other medications after treatment with nitroprusside.

Nitropress (nitroprusside) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have any of these serious side effects:

feeling extremely light-headed, even while lying down;

confusion, ringing in your ears;

fainting, breathing that stops;

gasping or struggling to breathe;

dizziness with nausea and vomiting, confusion, rapid breathing, and seizure;

tremors, chills, bowel or bladder urgency;

fast, slow, or uneven heart rate;

easy bruising or bleeding; or

muscle pain or weakness, numb or cold feeling in your arms and legs.

Less serious side effects may be more likely to occur, such as:

skin rash;

warmth, redness, or tingly feeling under your skin;

darkening or deeper color of veins through your skin; or

pain or irritation where the needle is placed.

Side effects other than those listed here may also occur. Talk to your doctor about any side effect that seems unusual or that is especially bothersome. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nitropress (nitroprusside)?

Before receiving nitroprusside, tell your doctor if you take any blood pressure medications. You may not be able to receive nitroprusside, or you may need dosage adjustments or special tests during treatment.

There may be other drugs that can affect nitroprusside. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

NitroMist

NitroMist

Generic Name:

Treatment for:

The U.S. Food and Drug Administration (FDA) has approved NitroMist (Nitroglycerin Lingual Aerosol) for acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.

Data from the NitroMist clinical trials demonstrate the drug’s efficacy in the treatment of angina. In a double-blind, single-center, placebo-controlled, 4-period crossover study in 30 subjects with stable angina pectoris, doses of 0.2, 0.4, and 0.8 mg of nitroglycerin delivered by NitroMist were compared to placebo. The primary efficacy endpoint was exercise tolerance as measured by time to development of moderate angina while on an exercise treadmill. The primary endpoint was achieved with all three nitroglycerin oral spray groups demonstrating statistically significantly increase in time to angina compared to placebo (p less than or equal to 0.0003).

About NitroMist

NitroMist is an oral spray formulation of the drug most often used to treat angina pectoris, nitroglycerin. Angina is pain in the chest due to lack of blood and oxygen supply to the heart muscle resulting from an acute coronary syndrome and must be treated emergently. The American Heart Association estimates that over six million people in the United States suffer from angina.

Important Safety Information

Administration of NitroMist is contraindicated in patients who are using PDE5 inhibitors such as Viagra (sildenafil), Levitra (vardenafil), and Cialis (tadalafil). These products have been shown to potentiate the hypotensive effects of nitrate drugs such as NitroMist. NitroMist is also contraindicated in patients with severe anemia, increased intracranial pressure, or with a known hypersensitivity to nitrates or nitrites. Excessive use may lead to the development of tolerance. Severe hypotension, particularly with upright posture, may occur even with small doses of nitroglycerin. The drug should therefore be used with caution in patients who may be volume-depleted or who are already hypotensive. Nitroglycerin produces dose-related headaches, which may be severe.

Source:

NitroMist – Highlights of Prescribing Information

These highlights do not include all the information needed to use nitromist safely and effectively. See full

NitroMist Indications and Usage

NitroMist is a nitrate vasodilator indicated for acute relief of an attack or acute prophylaxis of angina pectoris due to coronary artery disease.

NitroMist Dosage and Administration

NitroMist Dosage Forms and Strengths

Lingual aerosol, 400 mcg per spray, 230 metered sprays per container

NitroMist Contraindications

NitroMist Warnings and Precautions

NitroMist Adverse Reactions

Most common adverse reactions are headache, flushing, hypotension, and syncope.

To report SUSPECTED ADVERSE REACTIONS, contact NovaDel Pharma at 1-908-782-3431 and or FDA at 1-800-FDA-1088 or

NitroMist Drug Interactions

NitroMist Patient Counseling Information

For more information, please see

More NitroMist resources

Nitrol Appli-Kit

Nitrol Appli-Kit

Generic Name: nitroglycerin (topical) (NYE troe GLIS er in)

What is Nitrol Appli-Kit (nitroglycerin (topical))?

Nitroglycerin is in a group of drugs called nitrates. Nitroglycerin dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Nitroglycerin topical (for the skin) is used to prevent attacks of chest pain (angina).

Nitroglycerin topical may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Nitrol Appli-Kit (nitroglycerin (topical))?

You should not use this medication if you are allergic to nitroglycerin, isosorbide mononitrate (Imdur), or isosorbide dinitrate (BiDil, Isordil).

Before using nitroglycerin topical, tell your doctor if you have congestive heart failure, low blood pressure, glaucoma, anemia, or a history of heart attack, stroke, or head injury.

Do not use this medication to treat an angina attack that has already begun. It will not work fast enough.

Nitroglycerin topical can cause severe headaches, especially when you first start using it. Do not stop using nitroglycerin, and ask your doctor before using any headache pain medication.

Nitroglycerin topical can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin topical. Call your doctor at once if you have a serious side effect such as worsening chest pain, pain spreading to the arm or shoulder, nausea, vomiting, sweating, blurred vision and dry mouth, or fainting.

What should I discuss with my healthcare provider before using Nitrol Appli-Kit (nitroglycerin (topical))?

You should not use this medication if you are allergic to nitroglycerin, isosorbide mononitrate (Imdur), or isosorbide dinitrate (BiDil, Isordil).

Before using nitroglycerin topical, tell your doctor if you are allergic to any drugs, or if you have:

congestive heart failure;

a history of heart attack, stroke, or head injury;

low blood pressure;

glaucoma; or

anemia (lack of red blood cells).

If you have any of these conditions, you may need a dose adjustment or special tests to safely use nitroglycerin topical.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether nitroglycerin topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Nitroglycerin topical can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use nitroglycerin topical. Do not stop using the medication. Ask your doctor before using any headache pain medication.

If you need to have any type of surgery or dental work, tell the surgeon or dentist ahead of time that you are using nitroglycerin topical.

How should I use Nitrol Appli-Kit (nitroglycerin (topical))?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

Do not use nitroglycerin topical to treat an angina attack that has already begun. It will not work fast enough. Your doctor may prescribe an oral form of nitroglycerin (tablet, capsule, spray) to treat an angina attack. Talk with your doctor if any of your medications do not seem to work as well in treating or preventing angina attacks.

Nitroglycerin ointment is usually applied 3 or 4 times daily. You may also need to wash off the ointment at a certain time each day. Follow your doctor’s instructions carefully.

Wash your hands after applying nitroglycerin ointment. Do not stop using this medication without your doctor’s advice, even if you feel better. You may have increased angina attacks if you stop using the medication suddenly. Store this medication at room temperature, away from moisture and heat.

What happens if I miss a dose?

Apply the medicine as soon as you remember. If your next dose is less than 2 hours away, wait until then to apply the ointment and skip the missed dose.

Do not use extra ointment to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include a severe throbbing headache, confusion, fever, fast or pounding heartbeats, dizziness, vision problems, nausea, vomiting, bloody diarrhea, trouble breathing, cold or clammy skin, feeling light-headed, fainting, seizure (convulsions), or blue-colored skin, lips, or nails.

What should I avoid while using Nitrol Appli-Kit (nitroglycerin (topical))?

Avoid using nitroglycerin topical on irritated or broken skin.

Nitroglycerin topical can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin topical.

Nitrol Appli-Kit (nitroglycerin (topical)) side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

worsening chest pain, slow heart rate;

feeling like you might pass out;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

fast or pounding heartbeats; or

blurred vision and dry mouth.

Less serious side effects may include:

mild skin rash or itching;

warmth, redness, or tingly feeling under your skin;

nausea, vomiting, upset stomach; or

feeling nervous, weak, or dizzy.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nitrol Appli-Kit (nitroglycerin (topical))?

Tell your doctor about all other medications you use, especially:

blood pressure medication or diuretics (water pills);

cold or allergy medicines, diet pills, or over-the-counter pain medicine such as ibuprofen (Advil, Motrin) or naproxen (Aleve);

an erectile dysfunction medication such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);

migraine headache medication such as ergotamine (Ergomar, Cafergot), or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);

a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), and others; or

a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan).

This list is not complete and there may be other drugs that can interact with nitroglycerin topical. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Nitrogard

Nitrogard

Nitrogard is used for:

Preventing chest pain caused by heart disease. It may also be used to treat other conditions as determined by your doctor.

Nitrogard is a nitrate. It works by widening blood vessels in the body, which allows more blood to flow more easily through them and reduces the work the heart has to do to pump blood. This reduces the oxygen need of the heart, and helps prevent chest pain.

Do NOT use Nitrogard if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nitrogard :

Some medical conditions may interact with Nitrogard . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Nitrogard . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nitrogard may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nitrogard :

Use Nitrogard as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Nitrogard .

Important safety information:

Possible side effects of Nitrogard :

All medicines may cause side effects, but many people have no, or minor, side effects.

Burning or tingling in the mouth; dizziness; flushing; headache; heavy sweating; lightheadedness; nausea; pale skin; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; fainting; increased chest pain; pounding in the chest; slow heartbeat.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in bathroom. Keep Nitrogard out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Nitrogard . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

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Nitrocot

Nitrocot

Generic Name: nitroglycerin (Oral route, Sublingual route)

nye-troe-GLIS-er-in

Commonly used brand name(s):

Available Dosage Forms:

Therapeutic Class: Antianginal

Chemical Class: Nitrate

Uses For Nitrocot

Nitroglycerin is used to prevent angina (chest pain) caused by coronary artery disease. This medicine is also used to relieve an angina attack that is already occurring.

Nitroglycerin belongs to the group of medicines called nitrates. It works by relaxing the blood vessels and increasing the supply of blood and oxygen to the heart while reducing its work load. When used regularly on a long-term basis, or just before exercise or a stressful event, this helps prevent angina attacks from occurring.

This medicine is available only with your doctor’s prescription.

Before Using Nitrocot

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nitroglycerin in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nitroglycerin in the elderly. However, elderly patients are more likely to have age-related liver, kidney, or heart problems, which may require caution and an adjustment in the dose for patients receiving nitroglycerin.

Pregnancy

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:

Proper Use of nitroglycerin

Nitroglycerin is available as two types of products that are used for different reasons. The

When you begin to feel an attack of angina starting (chest pains; tightness or squeezing in the chest), sit down. Then place a

Nitroglycerin

Nitroglycerin

Swallow the

You should take the

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the

Store the

Precautions While Using Nitrocot

If you will be taking this medicine for a long time,

Do not take sildenafil (Viagra®), tadalafil (Cialis®), or vardenafil (Levitra®) while you are using this medicine. Using these medicines together may cause blurred vision, dizziness, lightheadedness, or fainting. If you are taking these medicines and you experience an angina attack, you must go to the hospital right away.

This medicine may cause headaches. These headaches are a sign that the medicine is working. Do not stop using the medicine or change the time you use it in order to avoid the headaches. If you have severe pain, talk with your doctor.

Dizziness, lightheadedness, or faintness may occur, especially when you get up quickly from a lying or sitting position. Getting up slowly may help.

Dizziness, lightheadedness, or fainting is also more likely to occur if you drink alcohol, stand for long periods of time, exercise, or if the weather is hot.

Blurred vision or dryness of the mouth may occur while using this medicine. Check with your doctor if this concerns you.

Serious skin reactions can occur with this medicine. Check with your doctor right away if you have cracks in the skin; feeling of warmth; loss of heat from the body; rash; red, swollen skin; redness of the face, neck, arms and occasionally, upper chest; or scaly skin while you are using this medicine.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

Nitrocot Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

The information contained in the Thomson Healthcare (Micromedex) products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Healthcare products is at your sole risk. These products are provided “AS IS” and “as available” for use, without warranties of any kind, either express or implied. Thomson Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Healthcare does not assume any responsibility or risk for your use of the Thomson Healthcare products.

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Nitro-Time

Nitro-Time Controlled-Release Capsules

Nitro-Time Controlled-Release Capsules are used for:

Preventing chronic chest pain caused by heart disease. It also may be used for other conditions as determined by your doctor.

Nitro-Time Controlled-Release Capsules are a nitrate. It works by relaxing (widening) blood vessels. Chest pain occurs when the heart needs more oxygen than it can get. Relaxing blood vessels allows blood to flow more easily. This reduces the heart’s workload and the amount of oxygen needed by the heart.

Do NOT use Nitro-Time Controlled-Release Capsules if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Nitro-Time Controlled-Release Capsules:

Some medical conditions may interact with Nitro-Time Controlled-Release Capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Nitro-Time Controlled-Release Capsules. Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Nitro-Time Controlled-Release Capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Nitro-Time Controlled-Release Capsules:

Use Nitro-Time Controlled-Release Capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Nitro-Time Controlled-Release Capsules.

Important safety information:

When used for long periods of time without a break, Nitro-Time Controlled-Release Capsules may not work as well. This is known as TOLERANCE. Increasing the dose is not effective in managing tolerance to Nitro-Time Controlled-Release Capsules. Tolerance to other nitrates or nitrites may also occur. Be sure to have a “nitrate-free” period of time each day to help prevent this tolerance. Talk with your doctor if Nitro-Time Controlled-Release Capsules stops working well. Do not take more than prescribed.

Some people who use Nitro-Time Controlled-Release Capsules for a long time without a break may develop a physical need to continue taking it. This is known as physical DEPENDENCE. If you use Nitro-Time Controlled-Release Capsules without a break and then suddenly stop using it, you may get WITHDRAWAL symptoms. These may include chest pain, heart attack, or possibly sudden death. Be sure to have a “nitrate-free” period of time each day; this may help prevent dependence and withdrawal problems.

Possible side effects of Nitro-Time Controlled-Release Capsules:

All medicines may cause side effects, but many people have no, or minor, side effects.

Dizziness, lightheadedness, or fainting when sitting up or standing; flushing of face and neck; headache; nausea; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; dry mouth; fainting; flushing; heavy sweating; irregular heartbeat; new or worsening chest pain; pale skin; pounding in the chest; rapid heartbeat; severe dizziness or headache; severe or persistent nausea or vomiting; shortness of breath; slow heartbeat; swelling of the hands, ankles, or feet; unusual weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Nitro-Time Controlled-Release Capsules at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Nitro-Time Controlled-Release Capsules out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Nitro-Time Controlled-Release Capsules. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Nitro-Time Controlled-Release Capsules resources

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Nitro TD Patch-A

Nitro TD Patch-A

Generic Name: nitroglycerin (transdermal) (NYE troe GLIS er in)

What is Nitro TD Patch-A (nitroglycerin (transdermal))?

Nitroglycerin is in a group of drugs called nitrates. Nitroglycerin dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump.

Nitroglycerin transdermal is used to prevent attacks of chest pain (angina).

Nitroglycerin transdermal may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about Nitro TD Patch-A (nitroglycerin (transdermal))?

You should not use this medication if you are allergic to nitroglycerin, isosorbide mononitrate (Imdur), or isosorbide dinitrate (BiDil, Isordil).

Before using nitroglycerin transdermal, tell your doctor if you have congestive heart failure, low blood pressure, glaucoma, anemia, or a history of heart attack, stroke, or head injury.

Do not use this medication to treat an angina attack that has already begun. It will not work fast enough.

Nitroglycerin transdermal can cause severe headaches, especially when you first start using it. Do not stop using the skin patches, and ask your doctor before using any headache pain medication.

Nitroglycerin transdermal can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert. Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin transdermal. Call your doctor at once if you have a serious side effect such as worsening chest pain, pain spreading to the arm or shoulder, nausea, vomiting, sweating, blurred vision and dry mouth, or fainting.

What should I discuss with my healthcare provider before using Nitro TD Patch-A (nitroglycerin (transdermal))?

You should not use this medication if you are allergic to nitroglycerin, isosorbide mononitrate (Imdur), or isosorbide dinitrate (BiDil, Isordil). Do not use nitroglycerin transdermal if you are allergic to any type of adhesive on a bandage or other transdermal skin patch.

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before using nitroglycerin transdermal, tell your doctor if you have:

congestive heart failure;

a history of heart attack, stroke, or head injury;

low blood pressure;

glaucoma; or

anemia (lack of red blood cells).

Tell any doctor or other healthcare provider who treats you that you are using nitroglycerin skin patches. If you need emergency heart resuscitation, your family or caregivers should tell emergency medical personnel if you are wearing a nitroglycerin skin patch. The patch should be removed before any electrical equipment (such as a defribrillator) is used on you.

How should I use Nitro TD Patch-A (nitroglycerin (transdermal))?

Use this medication exactly as it was prescribed for you. Do not use the medication in larger amounts, or use it for longer than recommended by your doctor. Follow the directions on your prescription label.

Do not use nitroglycerin transdermal to treat an angina attack that has already begun. It will not work fast enough. Your doctor may prescribe an oral form of nitroglycerin (tablet, capsule, spray) to treat an angina attack. Talk with your doctor if any of your medications do not seem to work as well in treating or preventing angina attacks.

The nitroglycerin transdermal skin patch is usually worn for 12 to 14 hours and then removed. A new patch is put on after a “patch-free” period of 10 to 12 hours. Your doctor may want you to wear the patch for longer or shorter periods of time. Follow your doctor’s instructions carefully.

Apply the skin patch to a clean, dry, hairless area of the body, below your neck and above your knees or elbows. To remove any hair from these skin areas, clip the hair short but do not shave it.

Press the patch onto the skin and press it down firmly with your fingers. Make sure it is well sealed around the edges.

Wash your hands after applying a nitroglycerin transdermal skin patch.

If the patch falls off, try sticking it back on. If you replace the patch with a new one, leave it on only for the rest of your wearing time. Do not change your patch removal schedule.

After removing a skin patch fold it in half, sticky side in, and throw it away in a place where children or pets cannot get to it. Keep both used and unused nitroglycerin skin patches out of the reach of children or pets. Do not stop using this medication without your doctor’s advice, even if you feel better. You may have increased angina attacks if you stop using the medication suddenly. Store this medication at room temperature, away from moisture and heat. Keep each skin patch in its sealed pouch until you are ready to use it.

What happens if I miss a dose?

Apply a patch as soon as you remember, and keep it on for the rest of your wearing time without changing your patch removal schedule. If you miss a dose and it is almost time to apply your next patch, wait until then to apply the patch and skip the missed dose.

Do not use extra patches to make up a missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include a severe throbbing headache, confusion, fever, fast or pounding heartbeats, dizziness, vision problems, nausea, vomiting, bloody diarrhea, trouble breathing, cold or clammy skin, feeling light-headed, fainting, seizure (convulsions), or blue-colored skin, lips, or nails.

What should I avoid while using Nitro TD Patch-A (nitroglycerin (transdermal))?

Avoid using nitroglycerin transdermal on irritated or broken skin.

Nitroglycerin transdermal can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Avoid drinking alcohol. It can increase some of the side effects of nitroglycerin transdermal.

Nitro TD Patch-A (nitroglycerin (transdermal)) side effects

Nitroglycerin transdermal can cause severe headaches, especially when you first start using it. These headaches may gradually become less severe as you continue to use nitroglycerin transdermal. Do not stop using the medication. Ask your doctor before using any headache pain medication.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

worsening chest pain, slow heart rate;

feeling like you might pass out;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

fast or pounding heartbeats; or

blurred vision and dry mouth.

Less serious side effects may include:

mild skin rash or itching;

warmth, redness, or tingly feeling under your skin;

nausea, vomiting, upset stomach; or

feeling nervous, weak, or dizzy.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Nitro TD Patch-A (nitroglycerin (transdermal))?

Tell your doctor about all other medications you use, especially:

blood pressure medication or diuretics (water pills);

cold or allergy medicines, diet pills, or over-the-counter pain medicine such as ibuprofen (Advil, Motrin) or naproxen (Aleve);

an erectile dysfunction medication such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);

migraine headache medication such as ergotamine (Ergomar, Cafergot), or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray);

a beta-blocker such as atenolol (Tenormin), carvedilol (Coreg), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), and others; or

a calcium channel blocker such as amlodipine (Norvasc), diltiazem (Tiazac, Cartia, Cardizem), felodipine (Plendil), nicardipine (Cardene), nifedipine (Procardia, Adalat), nimodipine (Nimotop), nisoldipine (Sular), or verapamil (Calan, Covera, Isoptin, Verelan).

This list is not complete and there may be other drugs that can interact with nitroglycerin transdermal. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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