Nitrostat Tablets

Why is Nitrostat Tablets prescribed?

Nitroglycerin is prescribed to prevent and treat angina pectoris (suffocating chest pain). This condition occurs when the coronary arteries become constricted and are not able to carry sufficient oxygen to the heart muscle. Nitroglycerin is thought to improve oxygen flow by relaxing the walls of arteries and veins, thus allowing them to dilate.

Nitroglycerin is used in different forms. As a patch or ointment, nitroglycerin may be applied to the skin. The patch and the ointment are for

Swallowing nitroglycerin in capsule or tablet form also helps to

In the form of sublingual (held under the tongue) or buccal (held in the cheek) tablets, or in oral spray (sprayed on or under the tongue), nitroglycerin helps relieve chest pain that has

Most important fact about Nitrostat Tablets

Nitroglycerin may cause severe low blood pressure (possibly marked by dizziness or light-headedness), especially if you are in an upright position or have just gotten up from sitting or lying down. You may also find your heart rate slowing and your chest pain increasing. People taking diuretic medication, or who have low systolic blood pressure (less than 90 mm Hg) should use nitroglycerin with caution.

How should you take Nitrostat Tablets?

Since nitroglycerin is available in many forms, it is crucial for you to follow your doctor’s directions for taking the type of nitroglycerin prescribed for you. Never interchange brands.

Ideally, you should take nitroglycerin while sitting down—especially if you feel dizzy or light-headed—so as to avoid a fall.

Avoid puncturing the spray container and keep it away from excess heat.

Do not open the container of sublingual tablets until you need a dose. Close the container tightly immediately after each use. Do not put other medications, a cotton plug, or anything else in the container. Keep the sublingual tablets handy at all times. Keep the patches in the protective pouches they come in until use.

What side effects may occur?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking nitroglycerin.

Why should Nitrostat Tablets not be prescribed?

You should not be using nitroglycerin if you are allergic to it or to the adhesive in the patch, if you have a head injury, or if you have any condition caused by increased fluid pressure in your head. Nitroglycerin should not be taken if you have severe anemia or if you recently had a heart attack. The capsule form should not be used if you have closed-angle glaucoma (pressure in the eye) or suffer from postural hypotension (dizziness upon standing up). Do not take the tablets if you are using the impotence drug sildenafil.

Special warnings about Nitrostat Tablets

If your vision becomes blurry or your mouth becomes dry while taking nitroglycerin, it should be discontinued. Contact your doctor immediately if these symptoms develop.

You may develop acute headaches if you take nitroglycerin excessively. Also, some people may develop a tolerance to nitroglycerin, and it may become less beneficial over time, especially if used in excess.

Nitroglycerin tablets lose their effectiveness when exposed to air. If you are taking sublingual nitroglycerin, you may notice a burning or tingling sensation. This does not necessarily mean that tablets which have been exposed to air for a long period of time are still good.

Take no more than the smallest possible amount needed to relieve pain.

Daily headaches may be an indicator of the drug’s activity. Do not change your dose to avoid the headache, because you may reduce the drug’s effectiveness at the same time.

Before taking nitroglycerin, tell your doctor if you have had a recent heart attack, head injury, or stroke; or if you have anemia, glaucoma (pressure in the eye), or heart, kidney, liver, or thyroid disease.

If you use a patch, dispose of it carefully. There is enough drug left in a used patch to be harmful to children and pets.

Since nitroglycerin can cause dizziness, you should observe caution while driving, operating machinery, or performing other tasks that demand concentration.

The benefits of applying nitroglycerin to the skin of people experiencing heart attacks or congestive heart failure have not been established. If you are using the medication for these conditions, your doctor will monitor you to prevent low blood pressure and pounding heartbeat.

Possible food and drug interactions when taking Nitrostat Tablets

If nitroglycerin is taken with certain other drugs, the effects of either could be increased, decreased, or altered.

Taken with many high blood pressure drugs, nitroglycerin may cause extreme low blood pressure (dizziness, fainting, numbness). Take particular care with calcium channel blockers such as nifedipine and verapamil, as well as isosorbide dinitrate, isosorbide mononitrate, blood vessel dilators such as minoxidil, and beta-blocker medications such as atenolol. Nitroglycerin may also cause a severe drop in blood pressure when taken with the impotence drug sildenafil.

Aspirin can increase the effects of nitroglycerin.

Alcohol may interact with nitroglycerin and cause a swift decrease in blood pressure, possibly causing dizziness and fainting.

Also be alert for an interaction with dihydroergotamine. Check with your doctor if you are uncertain about any combination you plan to take.

Special information if you are pregnant or breastfeeding

It has not been determined whether nitroglycerin might harm a fetus or a pregnant woman. As a result, nitroglycerin should be used only when the benefits of therapy clearly outweigh the potential risks to the fetus and woman. It is not known if nitroglycerin appears in breast milk; therefore, a nursing mother should use nitroglycerin only on advice of her doctor.

Recommended dosage for Nitrostat Tablets

The following section is intended to provide guidelines for taking nitroglycerin. Follow your doctor’s instructions carefully for using nitroglycerin in the form prescribed for you.

ADULTS

At the first sign of chest pain, 1 tablet should be dissolved under the tongue or inside the cheek. You may repeat the dose every 5 minutes until the pain is relieved. If your pain continues after you have taken 3 tablets in a 15-minute period, notify your doctor or seek medical attention immediately.

You may take sublingual or buccal nitroglycerin from 5 to 10 minutes before starting activities that may cause chest pain.

A patch is applied to the skin for 12 to 14 hours. After this time, the patch is removed; it is not applied again for 10 to 12 hours (a “patch-off” period). Apply the patch as soon as you remove it from its protective pouch.

At the first sign of chest pain, spray 1 or 2 pre-measured doses onto or under the tongue. You should not use more than 3 doses within a 15-minute period. If your chest pain continues, you should contact your doctor or seek medical attention immediately.

The spray can be used 5 to 10 minutes before activity that might precipitate an attack.

Your initial dose may be a daily total of 1 inch of ointment. Apply one-half inch on rising in the morning, and the remaining one-half inch 6 hours later. If needed, follow your doctor’s instructions for increasing your dosage. Apply in a thin, uniform layer, regardless of the amount of your dosage. There should be a daily period where no ointment is applied. Usually, the “ointment-off” period will last from 10 to 12 hours.

Absorption varies with site of application—more is absorbed through the chest.

The smallest effective amount should be taken 2 or 3 times a day at 8- to 12-hour intervals.

CHILDREN

The safety and effectiveness of nitroglycerin have not been established for children.

OLDER ADULTS

In general, dosages less than the above adult dosages are recommended, since the elderly may be more susceptible to low blood pressure and headaches.

Overdosage

Any medication taken in excess can have serious consequences. Severe overdosage of nitroglycerin may result in death. If you suspect an overdose, seek medical attention immediately.

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