• Advertisement

Archive for the ‘mitotic inhibitors’ Category

Vumon

Posted by admin on November 2nd, 2009

Vumon

Severe infections or bleeding can occur with Vumon .

Vumon is used for:

Treating certain types of leukemia. Vumon is used in combination with other medicines.

Vumon is an antineoplastic. It works by damaging the tumor cell’s DNA, resulting in tumor cell death.

Do NOT use Vumon if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Vumon :

Some medical conditions may interact with Vumon . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Vumon . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Vumon may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Vumon :

Use Vumon as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Vumon .

Important safety information:

Possible side effects of Vumon :

All medicines may cause side effects, but many people have no, or minor, side effects.

Diarrhea; hair loss; nausea; rash; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; fainting; fast or irregular heartbeat; fever, chills, sore throat, or cough; flushing; mouth sores; pain, redness, or swelling at the injection site; severe or persistent dizziness or headache; severe or persistent nausea, vomiting, or diarrhea; unusual bruising or bleeding; unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Vumon in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C) in the original package. Store away from heat and light. Keep Vumon , as well as needles and syringes, out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Vumon . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Vumon resources

Compare Vumon with other medications for the treatment of:

Posted in mitotic inhibitors Tags: , No Comments »

VePesid

Posted by admin on November 2nd, 2009

VePesid

VePesid may decrease your body’s ability to fight infections (due to bone marrow suppression). Immediately notify your doctor if you develop symptoms of an infection (persistent sore throat, fever), easy bruising or bleeding, or unusual fatigue. Your doctor will closely monitor you while you are using VePesid .

VePesid is used for:

Treating patients with lung cancer and recurrent testicular tumors. It is used in combination with other cancer medications.

VePesid is an antineoplastic. It works by stopping the tumor cells from dividing (mitosis), which prevents the spread of certain types of cancer.

Do NOT use VePesid if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using VePesid :

Some medical conditions may interact with VePesid . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with VePesid . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if VePesid may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use VePesid :

Use VePesid as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use VePesid .

Important safety information:

Possible side effects of VePesid :

All medicines may cause side effects, but many people have no, or minor, side effects.

Appetite loss; bruising; diarrhea; hair loss; increased sweating; nausea; voice changes; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chills; cough; decreased ability to fight infection; dizziness; fever; loss of consciousness; seizure; sore throat; sores on the mouth or lips; temporary blindness; tingling of the fingers or toes; unusual bruising or bleeding; unusual tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store VePesid in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Keep VePesid out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about VePesid . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More VePesid resources

Compare VePesid with other medications for the treatment of:

Posted in mitotic inhibitors Tags: , No Comments »

Velban

Posted by admin on November 2nd, 2009

Velban

Generic Name: vinblastine (vin BLAS teen)

What is Velban (vinblastine)?

Vinblastine is cancer (antineoplastic) medication. Vinblastine interferes with the growth of cancer cells and slows their growth and spread in the body.

Vinblastine is used to treat some types of lymphoma, Hodgkin’s disease, testicular cancer, breast cancer, choriocarcinoma, mycosis fungoides, Kaposi’s sarcoma, and Letterer-Siwe disease.

Vinblastine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Velban (vinblastine)?

Vinblastine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of vinblastine including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection); severe nausea, vomiting, constipation, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with vinblastine.

Who should not use Velban (vinblastine)?

Do not use vinblastine without first talking to your doctor if you have

lung problems;

any type of infection; or

blood or bone marrow problems.

The use of vinblastine may be dangerous if you have any of the conditions listed above.

Vinblastine is in the FDA pregnancy category D. This means that vinblastine is known to be harmful to an unborn baby. Do not use vinblastine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with vinblastine. It is not know whether vinblastine passes into breast milk. Breast-feeding should be avoided during treatment with vinblastine.

How should I use Velban (vinblastine)?

Vinblastine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Tell your doctor or nurse right away if you notice redness, pain, or swelling at the place of injection or anywhere else on your skin.

Your doctor will determine the correct amount and frequency of treatment with vinblastine depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with vinblastine to monitor progress and side effects.

Your healthcare provider will store vinblastine as directed by the manufacturer. If you are storing vinblastine at home, follow the directions provided by your healthcare provider.

What happens if I miss a dose?

Contact your doctor if you miss a dose of vinblastine.

What happens if I overdose?

If, for any reason, an overdose of vinblastine is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Symptoms of a vinblastine overdose tend to be similar to side effects caused by the medication, although often more severe.

What should I avoid while using Velban (vinblastine)?

Vinblastine can lower the activity of your immune system making you susceptible to infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with vinblastine. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.

Talk to your doctor before taking glutamic acid or tryptophan as they may interfere with the action of vinblastine.

Velban (vinblastine) side effects

If you experience any of the following serious side effects from vinblastine, contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or sore throat, fever, chills, or signs of infection);

nerve problems (numbness, tingling, or burning in hands or feet);

soreness or inflammation or the mouth or sores on the lips or inside the mouth; or

pain, redness, or burning at the injection site.

Other, less serious side effects may be more likely to occur. Continue taking vinblastine and talk to your doctor if you experience:

hair loss;

jaw pain;

pain in the organs containing the cancer;

nausea, vomiting, constipation, or loss of appetite;

depression;

headache;

dizziness or vertigo;

hearing loss or changes in hearing;

weakness; or

tiredness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Velban (vinblastine)?

Do not receive “live” vaccines during treatment with vinblastine. Administration of a live vaccine may be dangerous during treatment with vinblastine.

Many drugs may interact with vinblastine. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with vinblastine.

Posted in mitotic inhibitors Tags: , No Comments »

Toposar

Posted by admin on November 2nd, 2009

Toposar

Toposar may decrease your body’s ability to fight infections (due to bone marrow suppression). Immediately notify your doctor if you develop symptoms of an infection (persistent sore throat, fever), easy bruising or bleeding, or unusual fatigue. Your doctor will closely monitor you while you are using Toposar .

Toposar is used for:

Treating lung cancer and testicular tumors in patients who have not responded to other treatment. It is used in combination with other cancer medications.

Toposar is an antineoplastic. It works by stopping the tumor cells from dividing (mitosis), which prevents the spread of certain types of cancer.

Do NOT use Toposar if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Toposar :

Some medical conditions may interact with Toposar . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Toposar . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Toposar may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Toposar :

Use Toposar as directed by your doctor. Check the label on the medicine for exact dosing instructions. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Toposar .

Important safety information:

Possible side effects of Toposar :

All medicines may cause side effects, but many people have no, or minor, side effects.

Appetite loss; back pain; blue or purple discoloration of the skin; diarrhea; hair loss; increased sweating; nausea; tightness in throat; voice changes; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chills; cough; decreased ability to fight infection; fever; leukemia; liver problems; loss of consciousness; low blood pressure; pain, redness, or swelling at injection site; sore throat; sores on the mouth or lips; temporary blindness; tingling of the fingers or toes; unusual bruising or bleeding; unusual tiredness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Toposar is usually handled and stored by a health care provider. If you are using Toposar at home, store Toposar as directed by your pharmacist or health care provider. Keep Toposar out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Toposar . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Toposar resources

Compare Toposar with other medications for the treatment of:

Posted in mitotic inhibitors Tags: , No Comments »

Taxotere

Posted by admin on November 2nd, 2009

Taxotere

Generic Name: docetaxel (doe se TAX el)

What is Taxotere?

Taxotere is a cancer medicine that slows the growth and spread of cancer cells in the body.

Taxotere is used to treat breast cancer, lung cancer, prostate cancer, stomach cancer, and head/neck cancer.

Taxotere may also be used for other purposes not listed in this medication guide.

Important information about Taxotere

Do not use this medication without your doctor’s consent if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Before being treated with Taxotere, tell your doctor if you have ever been treated with cisplatin (Platinol), or if you have liver disease, congestive heart failure, fluid retention, swelling problems, or if you have ever had an allergic reaction to docetaxel.

Taxotere can be harmful if it gets on your skin during an IV infusion. If this happens, wash the skin thoroughly with soap and warm water.

Some people receiving a Taxotere injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, light-headed, warm, or itchy, or if you have chest tightness or trouble breathing during the injection.

Taxotere can lower the blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection, especially fever.

There are many other drugs that can interact with Taxotere. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Before using Taxotere

Before being treated with Taxotere, tell your doctor if you have ever been treated with cisplatin (Platinol), or if you have:

congestive heart failure;

fluid retention or swelling problems; or

if you have ever had an allergic reaction to docetaxel.

If you have any of these conditions, you may need a dose adjustment or special tests to safely receive Taxotere.

FDA pregnancy category D. This medication can cause harm to an unborn baby. Do not use Taxotere without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether Taxotere passes into breast milk or if it could harm a nursing baby. Do not receive Taxotere without telling your doctor if you are breast-feeding a baby.

Adults older than 65 may be more sensitive to the side effects of Taxotere.

How is Taxotere used?

Taxotere is given as an injection through a needle placed into a vein. You will receive this medicine in a clinic or hospital setting. Taxotere must be given slowly through an IV and it may take up to an hour to complete your dose.

Your doctor may prescribe a steroid medicine for you to take for a few days before your injection. This will help prevent swelling or an allergic reaction to Taxotere. Do not miss any doses of the steroid.

Taxotere must be given slowly through an IV and it may take up to an hour to complete your dose.

Taxotere can be harmful if it gets on your skin during an IV infusion. If this happens, wash the skin thoroughly with soap and warm water.

Taxotere is usually given once every 3 weeks, and you may receive other cancer medicines at the same time. Your doctor will determine a treatment schedule for you based on the type of cancer being treated and other factors.

Taxotere can lower the blood cells that help your body fight infections. This can make it easier for you to get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled appointments.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Taxotere or the steroid medicine.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include fever, chills, body aches, flu symptoms, numbness, burning, pain, or tingly feeling, or white patches or sores inside your mouth or on your lips.

What should I avoid while using Taxotere?

Avoid getting a flu shot or vaccine while you are being treated with Taxotere. Vaccines may not work as well or could make you sick while you are using Taxotere.

Avoid contact with people who have colds, the flu, or other contagious illnesses. Contact your doctor immediately if you develop signs of infection, especially fever.

Avoid allowing this medicine to get on your skin during an IV infusion. If this does happen, wash the skin thoroughly with soap and warm water.

Taxotere side effects

Some people receiving a Taxotere injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, light-headed, warm, or itchy, or if you have chest tightness or trouble breathing during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

easy bruising or bleeding, unusual weakness;

feeling like you might pass out;

fever, chills, body aches, flu symptoms;

severe diarrhea;

skin changes or bruising where the IV was placed;

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);

feeling short of breath, even with mild exertion;

swelling of your ankles or feet, weight gain;

a red, blistering, peeling skin rash; or

numbness, burning, pain, or tingly feeling.

Less serious side effects may include:

feeling weak or tired;

white patches or sores inside your mouth or on your lips;

mild nausea, vomiting, diarrhea, constipation, or loss of appetite;

watery eyes;

changes in menstrual periods;

temporary hair loss; or

fingernail or toenail changes.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Taxotere?

Do not receive “live” vaccines during treatment with Taxotere. Administration of a live vaccine may be dangerous during treatment with Taxotere.

There are many other drugs that can interact with Taxotere. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Posted in mitotic inhibitors Tags: , No Comments »

Taxol

Posted by admin on November 2nd, 2009

Taxol

Generic Name: paclitaxel (PAK li TAK sel)

What is Taxol?

Taxol is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Taxol is used to treat breast cancer, lung cancer, and ovarian cancer. It is also used to treat AIDS-related Kaposi’s sarcoma.

Taxol may also be used for other purposes not listed in this medication guide.

Important information about Taxol

Do not use Taxol without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. You should not be given Taxol if you are allergic to paclitaxel, or to other medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). This includes cyclosporine (Gengraf, Neoral, Sandimmune) and teniposide (Vumon).

Before you receive Taxol, tell your doctor if you have liver disease, heart disease, or a severely weak immune system.

Taxol can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

There are many other medicines that can interact with Taxol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Before receiving Taxol

You should not be given Taxol if you are allergic to paclitaxel, or to other medications that contain an ingredient called Cremophor EL (polyoxyethylated castor oil). This includes cyclosporine (Gengraf, Neoral, Sandimmune) and teniposide (Vumon).

Before you receive Taxol, tell your doctor if you are allergic to any drugs, or if you have:

heart disease; or

a severely weak immune system.

If you have any of these conditions, you may need a dose adjustment or special tests to safely receive Taxol.

FDA pregnancy category D. Taxol can cause harm to an unborn baby. Do not receive Taxol without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether Taxol passes into breast milk or if it could harm a nursing baby. Do not receive Taxol without telling your doctor if you are breast-feeding a baby.

How is Taxol given?

Taxol is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. Taxol must be given slowly through an IV infusion, and can take up to 24 hours to complete.

Taxol is usually given every 3 weeks. Follow your doctor’s instructions.

Before your injection, you may be given other medications to help prevent a serious allergic reaction to Taxol.

Tell your caregivers if you feel any burning, pain, or swelling around the IV needle when the Taxol is injected.

If any of Taxol gets on your skin, wash the area with soap and warm water right away.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely while you are receiving Taxol.

Your heart rate may also be monitored through electrocardiograph or ECG (sometimes called an EKG). This machine measures electrical activity of the heart.

Taxol can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

What happens if I miss a dose?

Contact your doctor if you miss an appointment for your Taxol injection.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much Taxol.

Overdose symptoms may include numbness or tingling, fever, chills, mouth sores, unusual bleeding or weakness, or any signs of infection.

What should I avoid while using Taxol?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are being treated with Taxol.

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Taxol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; feeling like you might pass out; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

slow heart rate;

seizure (black-out or convulsions);

pale skin, easy bruising or bleeding, unusual weakness;

fever, chills, body aches, flu symptoms;

white patches or sores inside your mouth or on your lips;

numbness, tingling, or burning pain in your hands or feet;

increased blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats); or

warmth or redness under your skin.

Less serious side effects may include:

pain, swelling, redness, or skin color changes where the Taxol was injected;

joint or muscle pain;

mild nausea, vomiting, diarrhea; or

hair loss.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Taxol?

There are many other medicines that can interact with Taxol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

Posted in mitotic inhibitors Tags: , No Comments »

Onxol

Posted by admin on November 2nd, 2009

Onxol

Onxol must be administered in an appropriate medical setting. Serious allergic reactions, some fatal, have occurred with use of Onxol . DO NOT use Onxol again if you have experienced a severe allergic reaction to it. Stop using Onxol and notify your doctor immediately if you develop signs of an allergic reaction, such as rash; itching; severe dizziness; swelling of hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness. Certain patients with solid tumors or AIDS-related Kaposi sarcoma should not use Onxol . Frequent blood tests should be performed while you are using Onxol because of the risk of bone marrow suppression and serious infection.

Onxol is used for:

Treating ovary and breast cancer. It may be used for other types of cancer as determined by your doctor, which may not be listed in the professional package insert.

Onxol is a chemotherapy medicine. It works by slowing or stopping cancer cells from dividing and growing, so they eventually die.

Do NOT use Onxol if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Onxol :

Some medical conditions may interact with Onxol . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Onxol . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Onxol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Onxol :

Use Onxol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Onxol .

Important safety information:

Possible side effects of Onxol :

All medicines may cause side effects, but many people have no, or minor, side effects.

Cough; diarrhea; general feeling of discomfort; hair loss; mild discomfort, redness, or swelling at the injection site; mild joint or muscle pain; nausea; numbness, tingling, or burning of your arms, hands, legs, or feet; redness and/or sores on the mouth or lips; unusual weakness or tiredness; vomiting.

Severe allergic reactions (rash; hives; difficulty swallowing or breathing; tightness in the chest; flushing; swelling of the mouth, face, lips, tongue, or throat; hoarseness); blistering, swelling, redness, severe pain, or open sores on your skin or at the injection site; change in the amount of urine produced; chest pain; eye swelling or irritation; fainting; fast, slow, or irregular heartbeat; flu-like symptoms (fever, chills, sore throat); hearing trouble or loss of hearing; pale appearance; redness, swelling, or tenderness in the calf; ringing in the ears; seizures; severe joint or muscle pain; severe nausea, vomiting, or diarrhea; severe numbness, tingling, or burning in the arms, hands, legs, or feet; severe stomach pain; swelling of arms, hands, legs, or feet; sudden or severe dizziness, lightheadedness, or headache; unusual bruising or bleeding; vision changes or blurred vision.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Onxol as directed on the prescription label. Keep Onxol out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Onxol . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Onxol resources

Compare Onxol with other medications for the treatment of:

Posted in mitotic inhibitors Tags: , No Comments »

Oncovin

Posted by admin on November 2nd, 2009

Oncovin

Generic Name: vincristine (vin KRIS teen)

What is Oncovin (vincristine)?

Vincristine is a cancer (antineoplastic) medication. Vincristine interferes with the growth of cancer cells and slows their growth and spread in the body.

Vincristine is used in the treatment of leukemia. Vincristine has also been used in the treatment of Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, rhabdomyosarcoma, neuroblastoma, Wilms’ tumor, and other types of cancer.

Vincristine may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Oncovin (vincristine)?

Vincristine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of vincristine including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); nerve damage (burning, pricking, or tingling; loss of reflexes and difficulty in walking); severe nausea, vomiting, constipation, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with vincristine.

Who should not use Oncovin (vincristine)?

Do not use vincristine without first talking to your doctor if you have

a breathing or lung disease; or

Charcot-Marie-Tooth syndrome or another type of nerve or neuromuscular disease.

The use of vincristine may be dangerous if you have any of the conditions listed above.

Vincristine is in the FDA pregnancy category D. This means that vincristine is known to be harmful to an unborn baby. Do not use vincristine without first talking to your doctor if you are pregnant or could become pregnant during treatment. Contraceptive measures are recommended during treatment with vincristine. It is not know whether vincristine passes into breast milk. Breast-feeding should be avoided during treatment with vincristine.

How should I use Oncovin (vincristine)?

Vincristine should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with vincristine depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Tell your doctor or nurse right away if you notice redness, pain or swelling at the place of injection or anywhere else on your skin.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with vincristine to monitor progress and side effects.

Your healthcare provider will store vincristine as directed by the manufacturer. If you are storing vincristine at home, follow the directions provided by your healthcare provider.

What happens if I miss a dose?

Contact your doctor if you miss a dose of vincristine.

What happens if I overdose?

If for any reason an overdose of vincristine is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Symptoms of a vincristine overdose tend to be similar to side effects caused by the medication, although often more severe.

What should I avoid while using Oncovin (vincristine)?

There are no restrictions on food, beverages or activity during treatment with vincristine unless otherwise directed by your doctor.

Oncovin (vincristine) side effects

If you experience any of the following side effects from vincristine, contact your doctor:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

nerve problems (such as burning, pricking, or tingling; loss of reflexes, or difficulty walking);

little or no urine production, painful or difficult urination, or excessive urination;

constipation or abdominal cramps;

nausea, vomiting, or loss of appetite;

weight and muscle loss or wasting;

inflamation and sores on the lips or inside the mouth;

hearing problems;

vision problems;

jaw, throat, bone, back, or limb pain;

headache;

temporary hair loss; or

redness, burning, or irritation at the injection site.

Menstruation in women and sperm production in men may stop.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Oncovin (vincristine)?

Many drugs may interact with vincristine. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with vincristine.

Posted in mitotic inhibitors Tags: , No Comments »

Navelbine

Posted by admin on November 2nd, 2009

Navelbine

If Navelbine accidentally leaks into surrounding tissue, the skin and/or muscle may be severely damaged. Notify your doctor immediately if you feel pain or irritation at the injection site. Fatalities have occurred when medicines similar to vinorelbine were injected into the spine. This drug is for intravenous (IV; into a vein) use only.

Navelbine can cause blood disorders (eg, granulocytopenia) than can decrease your ability to fight infection. Notify your doctor immediately if you develop signs of infection, such as persistent sore throat or fever.

Navelbine is used for:

Treating cancer.

Navelbine is an antineoplastic. It works by targeting cancer cells and interfering with their reproduction.

Do NOT use Navelbine if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Navelbine :

Some medical conditions may interact with Navelbine . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Navelbine . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Navelbine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Navelbine :

Use Navelbine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Navelbine .

Important safety information:

Possible side effects of Navelbine :

All medicines may cause side effects, but many people have no, or minor, side effects.

Diarrhea; hair loss; nausea; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; constipation; cough; numbness or tingling of your fingers or toes; pain, redness, or swelling at the injection site; shortness of breath; stomach pain; unusual bleeding or bruising.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Navelbine is usually handled and stored by a health care provider. If you are using Navelbine at home, store Navelbine as directed by your pharmacist or health care provider. Keep Navelbine out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Navelbine . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Navelbine resources

Compare Navelbine with other medications for the treatment of:

Posted in mitotic inhibitors Tags: , No Comments »

Ixempra

Posted by admin on November 2nd, 2009

Ixempra

Generic Name: ixabepilone (IX ab EP i lone)

What is Ixempra?

Ixempra is used to treat advanced breast cancer.

Ixempra is usually given after other cancer medications have been tried without successful treatment.

Ixempra may also be used for other purposes not listed in this medication guide.

Important information about Ixempra

You should not receive Ixempra if you are allergic to ixabepilone, or to a medication ingredient called Cremophor (synthetic castor oil). You may not be able to receive Ixempra if you have severe liver disease.

Do not use Ixempra without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

Before you receive Ixempra, tell your doctor if you have liver or heart disease, nerve problems in your hands or feet, diabetes, or bone marrow suppression.

Ixempra can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

Avoid drinking alcohol while you are receiving Ixempra. Tell your caregivers at once if you have serious side effects such as numbness, burning, pain, or tingly feeling in your hands or feet, sudden numbness or weakness, especially on one side of the body, chest pain or heavy feeling, fever, chills, body aches, flu symptoms, or redness, swelling, and pain on the palms of your hands or the soles of your feet.

Before receiving Ixempra

You should not receive Ixempra if you are allergic to ixabepilone, or to a medication ingredient called Cremophor (synthetic castor oil). You may not be able to receive Ixempra if you have severe liver disease.

Before you receive Ixempra, tell your doctor if you are allergic to any drugs, or if you have:

liver disease;

heart disease;

nerve problems (especially in your hands or feet);

diabetes; or

bone marrow suppression or weak immune system.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Ixempra.

FDA pregnancy category D. Ixempra can cause harm to an unborn baby. Do not use Ixempra without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether Ixempra passes into breast milk or if it could harm a nursing baby. Do not receive Ixempra without telling your doctor if you are breast-feeding a baby.

How is Ixempra given?

Ixempra is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. An Ixempra ijection is usually given every 3 weeks.

Ixempra must be given slowly through an IV infusion, and can take at least 3 hours to complete.

About 1 hour before you receive your Ixempra injection, you will be given other medications to help prevent an allergic reaction. You may also be given a steroid medication if you have ever had a reaction to an Ixempra injection.

Ixempra can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, wait until then to take the medicine and skip the missed dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of Ixempra.

An overdose of Ixempra is not expected to produce life-threatening symptoms.

What should I avoid while receiving Ixempra?

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Avoid drinking alcohol while you are receiving Ixempra.

Ixempra side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; warmth or tingly feeling; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have any of these serious side effects:

numbness, burning, pain, or tingly feeling in your hands or feet;

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

chest pain or heavy feeling;

fever, chills, body aches, flu symptoms; or

redness, swelling, and pain on the palms of your hands or the soles of your feet.

Less serious Ixempra side effects include:

tired feeling;

joint or muscle pain;

hair loss;

nausea, vomiting, diarrhea, stomach pain, loss of appetite;

diarrhea or constipation; or

white patches or sores inside your mouth or on your lips.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Ixempra?

The following drugs can interact with Ixempra. Tell your doctor if you are using any of these:

dexamethasone (Decadron, Hexadrol);

St. John’s wort;

a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Luminal, Solfoton);

HIV /AIDS medicine such as amprenavir (Agenerase), atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir), saquinavir (Invirase, Fortovase);

an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), griseofulvin (Fulvicin, Grifulvin, Grisactin), rifampin (Rifadin, Rimactane, Rifater), telithromycin (Ketek) or troleandomycin (Tao);

an antifungal medication such as itraconazole (Sporanox), ketoconazole (Nizoral), or voriconazole (Vfend);

seizure medication such as carbamazepine (Carbatrol, Tegretol) or phenytoin (Dilantin); or

an antidepressant such as amitriptyline (Elavil, Etrafon), doxepin (Sinequan), fluoxetine (Prozac), fluvoxamine (Luvox), imipramine (Janimine, Tofranil), nefazodone (Serzone), nortriptyline (Pamelor), paroxetine (Paxil), and others.

This list is not complete and there may be other drugs that can interact with Ixempra. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Posted in mitotic inhibitors Tags: , No Comments »
« Older Entries
Free T-Mobile phones on sale | Thanks to Best Savings Accounts, Conveyancing Fees and Used Cars