Nutropin Depot

Nutropin Depot Description

Nutropin Depot

Somatropin is a highly purified preparation. Biological potency is determined using a cell proliferation bioassay.

The Nutropin Depot formulation consists of micronized particles of rhGH embedded in biocompatible, biodegradable polylactide‑coglycolide (PLG) microspheres. Nutropin Depot is packaged in vials as a sterile, white to off‑white, preservative‑free, free‑flowing powder. Before administration, the powder is suspended in Diluent for Nutropin Depot (a sterile aqueous solution).

Each 13.5 mg 3 cc single‑use vial of Nutropin Depot contains 13.5 mg somatropin, 1.2 mg zinc acetate, 0.8 mg zinc carbonate, and 68.9 mg PLG.

Each 18 mg 3 cc single‑use vial of Nutropin Depot contains 18 mg somatropin, 1.6 mg zinc acetate, 1.1 mg zinc carbonate, and 91.8 mg PLG.

Each 22.5 mg 3 cc single‑use vial of Nutropin Depot contains 22.5 mg somatropin, 2.0 mg zinc acetate, 1.4 mg zinc carbonate, and 114.8 mg PLG.

Each dosage size contains an overage of rhGH microspheres to ensure delivery of labeled contents.

Each 1.5 mL single‑use vial of Diluent for Nutropin Depot contains 30 mg/mL carboxymethylcellulose sodium salt, 1 mg/mL polysorbate 20, 9 mg/mL sodium chloride, and sterile water for injection; pH 5.8–7.2.

Nutropin Depot – Clinical Pharmacology

General

In vivo preclinical and clinical testing has demonstrated that growth hormone (GH) stimulates longitudinal bone growth and elevates insulin‑like growth factor‑I (IGF‑I) levels.

Actions that have been demonstrated for hGH include:

Pharmacokinetics

Nutropin Depot is a long‑acting dosage form of somatropin designed to be administered by subcutaneous (SC) injection once or twice monthly. Following the injection, bioactive rhGH is released from the microspheres into the SC environment initially by diffusion, followed by both polymer degradation and diffusion. Although no studies have been performed that address the distribution, elimination, or metabolism of Nutropin Depot, once released and absorbed the rhGH is believed to be distributed and eliminated in a manner similar to somatropin formulated for daily administration.

The serum hGH concentration‑time profiles of single doses of 0.75 mg/kg and 1.5 mg/kg of Nutropin Depot have been characterized in pediatric GHD patients (refer to

Absorption—In a study of Nutropin Depot in pediatric patients with GHD, an SC dose of 0.75 mg/kg (n = 12) or 1.5 mg/kg (n = 8) was administered. The mean ± SD hGH C

Distribution—Animal studies with rhGH formulated for daily administration showed that GH localizes to highly perfused organs, particularly the liver and kidney. The volume of distribution at steady state for rhGH formulated for daily administration in healthy adult males is about 50 mL/kg body weight, approximating the serum volume.

Metabolism—Both the liver and kidney have been shown to be important metabolizing organs for GH. Animal studies using rhGH formulated for daily administration suggest that the kidney is the dominant organ of clearance. GH is filtered at the glomerulus and reabsorbed in the proximal tubules. It is then cleaved within renal cells into its constituent amino acids, which return to the systemic circulation.

Elimination—The mean terminal t

Figure 1

Special Populations

Pediatric—Available literature data suggest that rhGH clearances are similar in adults and children.

Gender—Following administration of either 0.75 mg/kg or 1.5 mg/kg Nutropin Depot, Day 1 GH levels were higher in females compared to males. No relationship was observed between gender and pharmacodynamic marker (IGF‑I and IGFBP‑3) levels.

Race—The effect of race on Nutropin Depot disposition is unknown due to the limited number of non‑Caucasian patients in the Nutropin Depot studies.

Growth Hormone Deficiency—Nutropin Depot has not been studied in healthy adults or children. However, reported values for clearance of rhGH formulated for daily administration in adults and children with GHD range from 138–245 mL/hr/kg and are similar to those observed in healthy adults and children. Mean terminal t

Renal Insufficiency—Nutropin Depot has not been studied in patients with renal insufficiency. Children and adults with chronic renal failure (CRF) and end‑stage renal disease (ESRD) tend to have decreased clearance of rhGH formulated for daily administration compared with normals. Endogenous GH production may also increase in some individuals with ESRD. However, no GH accumulation has been reported in children with CRF or ESRD dosed with daily regimens.

Hepatic Insufficiency—Nutropin Depot has not been studied in patients with hepatic insufficiency. A reduction in clearance of rhGH formulated for daily administration has been noted in patients with severe liver dysfunction. The clinical significance of this decrease is unknown.

Pharmacodynamics

IGF‑I levels peaked between 1.5 and 3.5 days postdose and remained above baseline for approximately 16 to 20 days, confirming GH activity for an extended period. Repeated dosing of Nutropin Depot over 6 months showed no progressive accumulation of IGF‑I (as shown in

Figure 2

Efficacy Studies

Pediatric Growth Hormone Deficiency (GHD)

In two multicenter, open‑label clinical studies in prepubertal children (mean age (± SD) 7.4±2.8) with idiopathic or organic GHD previously untreated with rhGH, 91 patients were treated with Nutropin Depot at 1.5 mg/kg once monthly or 0.75 mg/kg twice monthly by subcutaneous injection for up to six months. (See

Seventy‑six patients continued treatment in an extension study. For patients who completed 12 months the mean growth rate was 7.8±1.9 cm/yr for the two dose groups combined (n=69). Mean height SD score changed from –3.0±1.0 prestudy to –2.5±0.9 at Month 12 (n=69). The mean 0 to 12 month change in bone age was 1.0±0.4 years (n=63). During the long‑term extension study, fourteen of seventy‑five (19%) patients discontinued due to dissatisfaction with growth response. Historical studies of GHD children treated with daily Protropin

In a dose‑ranging study, 24 patients previously treated with daily GH (mean age 9.6±2.2 years; mean duration of prior GH therapy 2.8±1.6 yr, range 0.9 to 6.1 yr) were switched to Nutropin Depot therapy at the above doses. The mean growth rate on previous treatment was 8.2±3.0 cm/yr (range 3.2 to 13.1 cm/yr) and on Nutropin Depot was 5.1±2.0 cm/yr (range 2.4 to 9.6 cm/yr). During a long‑term extension study, four of ten previously treated patients discontinued due to dissatisfaction with growth response. Historical studies of GHD children (n=181) treated with daily Protropin or Nutropin at a dose of 0.3 mg/kg weekly had the following mean growth rates: first year growth rate 9.7 to 11.4 cm/yr; second year growth rate 8.1 to 8.9 cm/yr; third year growth rate 7.5 to 7.8 cm/yr; fourth year growth rate 6.6 to 7.1 cm/yr.

Indications and Usage for Nutropin Depot

Nutropin Depot

Considerations for use:—As with any GH treatment, patients should be monitored closely throughout therapy for growth response to Nutropin Depot. Failure to respond adequately requires careful assessment, as described under

Contraindications

Growth hormone should not be initiated to treat patients with acute critical illness due to complications following open heart or abdominal surgery, multiple accidental trauma, or to patients having acute respiratory failure. Two placebo‑controlled clinical trials in non‑growth hormone‑deficient adult patients (n = 522) with these conditions revealed a significant increase in mortality (41.9% vs. 19.3%) among somatropin‑treated patients (doses 5.3–8 mg/day) compared to those receiving placebo (see

Nutropin Depot should not be used for growth promotion in pediatric patients with closed epiphyses.

Nutropin Depot should not be used in patients with active neoplasia. GH therapy should be discontinued if evidence of neoplasia develops.

Growth hormone is contraindicated in patients with Prader‑Willi syndrome who are severely obese or have severe respiratory impairment

Warnings

See

There have been reports of fatalities after initiating therapy with growth hormone in pediatric patients with Prader‑Willi syndrome who had one or more of the following risk factors: severe obesity, history of upper airway obstruction or sleep apnea, or unidentified respiratory infection. Male patients with one or more of these factors may be at greater risk than females. Patients with Prader‑Willi syndrome should be evaluated for signs of upper airway obstruction and sleep apnea before initiation of treatment with growth hormone. If during treatment with growth hormone, patients show signs of upper airway obstruction (including onset of or increased snoring) and/or new onset sleep apnea, treatment should be interrupted. All patients with Prader‑Willi syndrome treated with growth hormone should also have effective weight control and be monitored for signs of respiratory infection, which should be diagnosed as early as possible and treated aggressively (see

Precautions

General: Nutropin Depot should be prescribed by physicians experienced in the diagnosis and management of patients with GHD.

Because GH may reduce insulin sensitivity, patients should be monitored for evidence of glucose intolerance.

For patients with diabetes mellitus, the insulin dose may require adjustment when GH therapy is instituted. Because GH may reduce insulin sensitivity, particularly in obese individuals, patients should be observed for evidence of glucose intolerance. Patients with diabetes or glucose intolerance should be monitored closely during GH therapy.

Patients with symptomatic hypoglycemia associated with GHD should be closely monitored.

Patients with a history of an intracranial lesion should be examined frequently for progression or recurrence of the lesion. In pediatric patients, clinical literature has demonstrated no relationship between GH replacement therapy and central nervous system (CNS) tumor recurrence or new extracranial tumors.

Slipped capital femoral epiphysis may occur more frequently in patients with endocrine disorders or in patients undergoing rapid growth.

Progression of scoliosis can occur in patients who experience rapid growth. Because GH increases growth rate, patients with a history of scoliosis who are treated with GH should be monitored for progression of scoliosis. GH has not been shown to increase the incidence of scoliosis.

Intracranial hypertension (IH) with papilledema, visual changes, headache, nausea, and/or vomiting has been reported in a small number of patients treated with GH products. Symptoms usually occurred within the first 8 weeks of the initiation of GH therapy. In all reported cases, IH‑associated signs and symptoms resolved after termination of therapy or a reduction of the GH dose. Funduscopic examination of patients is recommended at the initiation and periodically during the course of GH therapy.

As with any protein, local or systemic allergic reactions may occur. Parents/Patients should be informed that such reactions are possible and that prompt medical attention should be sought if allergic reactions occur (see

Laboratory Tests: Serum levels of inorganic phosphorus, alkaline phosphatase, and parathyroid hormone (PTH) may increase with GH therapy.

Untreated hypothyroidism prevents optimal response to GH. Changes in thyroid hormone laboratory measurements may develop during GH treatment. Therefore, patients should have periodic thyroid function tests and should be treated with thyroid hormone when indicated.

Drug Interactions: Excessive glucocorticoid therapy will inhibit the growth‑promoting effect of human GH. Patients with ACTH deficiency should have their glucocorticoid‑replacement dose carefully adjusted to avoid an inhibitory effect on growth.

Limited published data indicate that GH treatment increases cytochrome P450 (CP450) mediated antipyrine clearance in humans. These data suggest that GH administration may alter the clearance of compounds known to be metabolized by CP450 liver enzymes (e.g., corticosteroids, sex steroids, anticonvulsants, cyclosporin). Careful monitoring is advisable when GH is administered in combination with other drugs known to be metabolized by CP450 liver enzymes.

Carcinogenesis, Mutagenesis, Impairment of Fertility: Carcinogenicity, mutagenicity, and fertility studies have not been conducted with Nutropin Depot.

Pregnancy Category C: Animal reproduction studies have not been conducted with Nutropin Depot. It is also not known whether Nutropin Depot can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Nutropin Depot should be given to a pregnant woman only if clearly needed.

Nursing Mothers: It is not known whether GH is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Nutropin Depot is administered to a nursing mother.

Information for Patients: Patients being treated with Nutropin Depot and/or their parents should be informed of the potential benefits and risks associated with treatment. If home use is determined to be desirable by the physician, instructions on appropriate use should be given, including a review of the contents of the Patient Information Insert. This information is intended to aid in the safe and effective administration of the medication. It is not a disclosure of all possible adverse or intended effects.

If home use is prescribed, a puncture‑resistant container for the disposal of used syringes and needles should be recommended to the patient. Patients and/or parents should be thoroughly instructed in the importance of proper disposal and cautioned against any reuse of needles and syringes (see Patient Information Insert).

Adverse Reactions

As with all protein pharmaceuticals, patients may develop antibodies to the protein. GH antibody‑binding capacities below 2 mg/L have not been associated with growth attenuation. In some cases when binding capacity exceeds 2 mg/L, growth attenuation has been observed. In clinical studies of pediatric patients who were treated with Nutropin Depot, 0/138 patients with GHD screened for antibody production developed antibodies with binding capacities ≥ 2 mg/L at any time during a treatment period of up to 17.4 months.

In addition to an evaluation of compliance with the prescribed treatment program and thyroid status, testing for antibodies to GH should be carried out in any patient who fails to respond to therapy.

In studies involving 138 pediatric patients treated with Nutropin Depot, the most frequent adverse reactions were injection‑site reactions, which occurred in nearly all patients. On average, 2 to 3 injection‑site adverse reactions were reported per injection. These reactions included nodules (61% of injections), erythema (53%), pain post‑injection (47%), pain during injection (43%), bruising (20%), itching (13%), lipoatrophy (13%), and swelling or puffiness (8%). The intensity of these reactions was generally rated mild to moderate, with pain during injection occasionally rated as severe (7%).

Adverse reactions observed less frequently in the Nutropin Depot studies which were considered possibly, probably, or definitely related to the drug by the treating physician (usually occurring 1–3 days postdose) included: headache (13% of subjects), nausea (8%), lower extremity pain (7%), fever (7%), and vomiting (5%). These symptoms were generally self‑limited and well‑tolerated. One patient experienced a generalized body rash that was most likely an allergic reaction to Nutropin Depot.

Leukemia has been reported in a small number of GHD patients treated with GH. It is uncertain whether this increased risk is related to the pathology of GH deficiency itself, GH therapy, or other associated treatments such as radiation therapy for intracranial tumors. On the basis of current evidence, experts cannot conclude that GH therapy is responsible for these occurrences.

Other adverse drug reactions that have been reported in GH‑treated patients include the following: 1) Metabolic: mild, transient peripheral edema; 2) Musculoskeletal: arthralgia, carpal tunnel syndrome; 3) Skin: rare increased growth of pre‑existing nevi; patients should be monitored for malignant transformation; 4) Endocrine: gynecomastia; and 5) Rare pancreatitis. Of these reactions, only edema (< 1% of patients) and arthralgia (4%) were reported as related to drug in the Nutropin Depot studies.

Overdosage

The recommended dosage of Nutropin Depot should not be exceeded. Acute overdosage could lead to fluid retention, headache, nausea, vomiting, and/or hyperglycemia. Long‑term overdosage could result in signs and symptoms of gigantism and/or acromegaly, consistent with the known effects of excess GH. (See

Nutropin Depot Dosage and Administration

The Nutropin Depot dosage and administration schedule should be individualized for each patient. Response to GH therapy in pediatric patients tends to decrease over time. However in pediatric patients, failure to increase growth rate, particularly during the first year of therapy, suggests the need for close assessment of compliance and evaluation of other causes of growth failure, such as hypothyroidism, undernutrition, and advanced bone age.

Once-Monthly Injection—It is recommended that an SC injection at a dosage of 1.5 mg/kg body weight be administered on the same day of each month. Dosages above the recommended once monthly regimen have not been studied in clinical trials. Note: subjects over 15 kg will require more than one injection per dose.

Twice-Monthly Injections—It is recommended that an SC injection at a dosage of 0.75 mg/kg body weight be administered twice each month on the same days of each month (e.g., Days 1 and 15 of each month). Dosages above the recommended twice‑monthly regimen have not been studied in clinical trials. Note: subjects over 30 kg will require more than one injection per dose.

The table below indicates the required number of injections per dose.

Preparation of Dose

Nutropin Depot powder may only be suspended in Diluent for Nutropin Depot supplied in the kit and administered with the supplied needles.

Stability and Storage

Before Suspension—Nutropin Depot and diluent vials must be stored at 2–8°C/36–46°F (under refrigeration). Avoid freezing the vials of Nutropin Depot and Diluent for Nutropin Depot. Do not expose the Nutropin Depot vial to temperatures above 25°C (77°F). Expiration dates are stated on the labels.

After Suspension—Because Nutropin Depot contains no preservatives, all injections must be given immediately. Do not allow the suspension to settle prior to withdrawal of the dose. Suspended solution cannot be stored or used to suspend another vial of Nutropin Depot.

How Supplied

Nutropin Depot is supplied as single‑use vials with 13.5 mg, 18 mg, or 22.5 mg sterile, preservative‑free somatropin powder per vial.

Each 13.5 mg kit contains one single‑use 13.5 mg vial of Nutropin Depot

Each 18 mg kit contains one single‑use 18 mg vial of Nutropin Depot

Each 22.5 mg kit contains one single‑use 22.5 mg vial of Nutropin Depot

Nutropin Depot

Genentech, Inc.

7217802

LF0535

(4819503)

Code Revision Date January 2004

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