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Archive for the ‘antineoplastic monoclonal antibodies’ Category

Y-90 Zevalin

Posted by admin on November 2nd, 2009

Y-90 Zevalin

Rituximab, a medicine used along with Y-90 Zevalin , may cause serious, sometimes fatal side effects, such as difficulty breathing, lung problems, heart attack, irregular heartbeats, or shock. If these side effects occur, they usually occur with the first infusion within 30 minutes to 2 hours. Seek immediate medical attention if you develop trouble breathing; swelling; dizziness; lightheadedness; fainting; irregular heartbeat; chest pain; numbness of an arm of leg; sudden, severe headache or vomiting; or sudden vision changes.

Y-90 Zevalin causes severe and prolonged blood problems in most patients. Patients who have certain bone marrow problems should not use Y-90 Zevalin . If you develop unusual bruising or bleeding, fever, chills, sore throat, or other signs of infection, contact your doctor immediately.

Severe and sometimes fatal skin problems have been reported with use of Y-90 Zevalin . If you experience red, swollen, blistered, or peeling skin, contact your doctor immediately.

Y-90 Zevalin is used for:

Treating non-Hodgkin lymphoma. It is used in combination with rituximab and 2 radioactive materials (In-111 and Y-90).

Ibritumomab is a monoclonal antibody protein. It works by binding to the cells that are involved in non-Hodgkin lymphoma. It is used in combination with 2 different radioactive materials. The first radioactive material (In-111) is attached to confirm that the cells are being reached. The second radioactive material (Y-90) is attached and damages the cells Y-90 Zevalin binds to, which helps to reduce the number of abnormal cells involved in non-Hodgkin lymphoma.

Do NOT use Y-90 Zevalin if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Y-90 Zevalin :

Some medical conditions may interact with Y-90 Zevalin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Y-90 Zevalin . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Y-90 Zevalin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Y-90 Zevalin :

Use Y-90 Zevalin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Y-90 Zevalin .

Important safety information:

Possible side effects of Y-90 Zevalin :

All medicines may cause side effects, but many people have no, or minor, side effects.

Anxiety; constipation; diarrhea; dizziness; flushing; headache; indigestion; joint or muscle pain; loss of appetite; nausea; runny nose; stomach pain or upset; sweating; throat irritation; trouble sleeping; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); back pain; black, bloody, or dark stools; chest pain; cough; fainting; fast or irregular heartbeat; lightheadedness; numbness of an arm or leg; pain, burning, swelling, or redness at the injection site; persistent or severe diarrhea; red, swollen, blistered, or peeling skin; severe stomach pain or swelling; severe tiredness or weakness; shortness of breath; signs of infection (fever, chills, persistent sore throat); sudden, severe or persistent headache; swelling of the hands, feet, or legs; unusual bruising or bleeding; unusual vaginal bleeding; vision problems; vomit that looks like coffee grounds; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Y-90 Zevalin is usually handled and stored by a health care provider. If you are using Y-90 Zevalin at home, store Y-90 Zevalin as directed by your pharmacist or health care provider. Keep Y-90 Zevalin out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Y-90 Zevalin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Y-90 Zevalin resources

Compare Y-90 Zevalin with other medications for the treatment of:

Posted in antineoplastic monoclonal antibodies Tags: , No Comments »

Soliris

Posted by admin on November 2nd, 2009

Soliris

Generic Name: eculizumab (E kue LIZ oo mab)

What is Soliris?

Soliris (eculizumab) is a monoclonal antibody that binds to proteins in the blood that can destroy red blood cells in people with a genetic condition that affects the natural defenses of red blood cells.

Soliris is used to prevent the breakdown of red blood cells in people with paroxysmal nocturnal hemoglobinemia (PNH).

Soliris may also be used for other purposes not listed in this medication guide.

Important information about Soliris

Soliris affects your immune system, and using this medication may increase your risk of serious infection such as meningitis. Get emergency medical help if you have any signs of meningitis, such as severe headache with fever, confusion, purple spots on the skin, and/or seizure (convulsions) and nausea or vomiting, stiffness in your neck or back, sensitivity to bright light, or a very high fever (103 degrees or higher), chills, body aches, or other flu-like symptoms.

With your medication you will receive a Patient Safety Card listing the symptoms of meningitis. Carry this card with you at all times. Seek emergency medical attention or call your doctor right away if you notice any of these symptoms.

You must be vaccinated against meningococcal infection at least 2 weeks before you start treatment with Soliris. If you have been vaccinated in the past, you may need a booster dose. It is best to stay current on all of your vaccinations before you receive Soliris, and your doctor may recommend other vaccines before or during treatment.

Before taking Soliris

Soliris affects your immune system, and using this medication may increase your risk of serious infection such as meningitis. Get emergency medical help if you have any signs of meningitis, such as severe headache with fever, confusion, skin rash, purple spots on the skin, and nausea or vomiting, stiffness in your neck or back, sensitivity to brightlight, or a high fever (103 degrees or higher), chills, body aches, and other flu-like symptoms.

With your medication you will receive a Patient Safety Card listing the symptoms of meningococcal infection. Carry this card with you at all times. Seek emergency medical attention or call your doctor right away if you notice any of these symptoms.

You should not use Soliris if you are allergic to eculizumab, or have bacterial meningitis. You must be vaccinated against meningococcal infection at least 2 weeks before you start treatment with Soliris. If you have been vaccinated in the past, you may need a booster dose. It is best to stay current on all of your vaccinations while you are using Soliris, and your doctor may recommend other vaccines before or during treatment.

Before using Soliris, tell your doctor if you are allergic to any drugs or if you have a fever or any type of infection.

FDA pregnancy category C. It is not known whether Soliris is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Soliris passes into breast milk or if it could harm a nursing baby. Do not use Soliris without telling your doctor if you are breast-feeding a baby.

How is Soliris given?

Soliris is given as an injection through a needle placed into a vein. Your doctor, nurse, or other healthcare provider will give you this injection. You may be shown how to use your medicine at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of needles, IV tubing, and other items used in giving the medicine.

Soliris is usually given every 7 days for 5 weeks, and then once every 2 weeks thereafter. The medicine must be given slowly through an IV infusion, and can take up to 2 hours to complete.

You may have a reaction to the infusion (when the medicine is injected into the vein). If this happens, you may need to slow down the speed of your IV infusion. A caregiver or family member should then watch you for at least 1 hour after your injection to make sure you have no further side effects.

Soliris must be mixed in an IV bag with a liquid (diluent) before injecting it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

Do not shake the medication vial (bottle). Vigorous shaking can ruin the medicine. Do not mix this medicine until you are ready to give yourself an injection. Do not use the medication if it has changed colors or has any particles in it. Call your doctor for a new prescription. To reduce discomfort from your injection, allow the mixed medicine to reach room temperature before using, but never warm the medicine in hot water or a microwave. You may store the mixture at room temperature but you must use it within 24 hours or throw the mixture away.

Use each disposable needle only one time. Throw away used needles in a puncture-proof container (ask your pharmacist where you can get one and how to dispose of it). Keep this container out of the reach of children and pets.

Do not stop using Soliris without first talking to your doctor. Stopping or interrupting your treatment could cause sudden and serious effects on your red blood cells. This may result in symptoms such as pale skin, easy bruising, confusion, chest pain, blood clots, or kidney problems.

If you stop using Soliris for any reason, your blood may need to be tested on a regular basis for at least 8 weeks. Do not miss any scheduled visits to your doctor during this follow-up period.

Store unopened Soliris in its original carton in the refrigerator, protected from light. Do not allow the medication to freeze.

What happens if I miss a dose?

Call your doctor for instructions if you miss a dose of Soliris.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Symptoms of an Soliris overdose are not known.

What should I avoid while taking Soliris?

Follow your doctor’s instructions about any restrictions on food, beverages, or activity while you are using Soliris.

Soliris side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:

severe headache with fever, confusion, purple spots on the skin, nausea or vomiting, and/or seizure (convulsions);

stiffness in your neck or back;

sensitivity to bright light;

high fever (103 degrees or higher), chills, body aches, flu symptoms;

any signs of a new illness or injection; or

signs that the medication is not working (pale skin, easy bruising, weakness, dark urine, feeling short of breath, or sudden numbness, severe headache, deep leg pain, or problems with vision, speech, or balance).

Less serious Soliris side effects may include:

nausea;

constipation;

mild headache;

runny nose, sore throat; or

back pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Soliris?

There may be other drugs that can interact with Soliris. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Posted in antineoplastic monoclonal antibodies Tags: , No Comments »

Mylotarg

Posted by admin on November 2nd, 2009

Mylotarg

Mylotarg should not be used along with other chemotherapy medicines. Severe bone marrow problems occur even at normal doses of Mylotarg . Severe and sometimes fatal allergic reactions and lung problems have occurred with use of Mylotarg . Tell the doctor immediately if you experience rash; hives; difficulty breathing; swelling of the mouth, face, lips, or tongue; or severe dizziness. Mylotarg may also increase the risk of severe and sometimes fatal liver problems. This risk may be increased if you have liver problems, you have had a hematopoietic stem-cell transplant (HSCT), or you use Mylotarg in combination with other chemotherapy medicines. Contact your doctor immediately if you experience sudden weight gain, right-sided stomach pain, stomach swelling, yellowing of the eyes or skin, or dark urine. Your doctor will monitor you closely while you use Mylotarg .

Mylotarg is used for:

Treating acute myeloid leukemia (AML) in patients 60 years of age and older who cannot take other cancer medications. It may also be used for other conditions as determined by your doctor.

Mylotarg is a chemotherapy agent. It works by binding to and breaking specific parts that the cancer cell needs to survive.

Do NOT use Mylotarg if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mylotarg :

Some medical conditions may interact with Mylotarg . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Mylotarg . However, no specific interactions with Mylotarg are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mylotarg may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mylotarg :

Use Mylotarg as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Mylotarg .

Important safety information:

Possible side effects of Mylotarg :

All medicines may cause side effects, but many people have no, or minor, side effects.

Back pain; constipation; cough; diarrhea; dizziness; fatigue; headache; indigestion; joint pain; loss of appetite; mouth sores; nausea; pain or inflammation at the injection site; runny nose; sleeplessness; stomach pain; vomiting; weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in amount or frequency of urine; chest pain; dark urine; depression; fast or irregular heart rate; fever, chills, or sore throat; increased thirst; one-sided weakness; pink or red-colored urine; right-sided stomach pain; seizure; severe dizziness; severe headache; shortness of breath; slurred speech; stomach swelling; sudden weight gain; swelling of the arms, legs, or feet; unusual bleeding or bruising (eg, nosebleed, red or purple spots under the skin, unusual vaginal bleeding); vision changes; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Mylotarg is usually handled and stored by a health care provider. If you are using Mylotarg at home, store Mylotarg as directed by your pharmacist or health care provider.

General information:

This information is a summary only. It does not contain all information about Mylotarg . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Mylotarg resources

Compare Mylotarg with other medications for the treatment of:

Posted in antineoplastic monoclonal antibodies Tags: , No Comments »

In-111 Zevalin

Posted by admin on November 2nd, 2009

In-111 Zevalin

Rituximab, a medicine used along with In-111 Zevalin , may cause serious, sometimes fatal side effects, such as difficulty breathing, lung problems, heart attack, irregular heartbeats, or shock. If these side effects occur, they usually occur with the first infusion within 30 minutes to 2 hours. Seek immediate medical attention if you develop trouble breathing, swelling, dizziness, lightheadedness, fainting, irregular heartbeat, chest pain, numbness of an arm or leg, sudden severe headache or vomiting, or sudden vision changes.

In-111 Zevalin causes severe and prolonged blood problems in most patients. Patients who have certain bone marrow problems should not use In-111 Zevalin . If you develop unusual bruising or bleeding, fever, chills, sore throat, or other signs of infection, contact your doctor immediately.

Severe and sometimes fatal skin problems have been reported with use of In-111 Zevalin . If you experience red, swollen, blistered, or peeling skin, contact your doctor immediately.

In-111 Zevalin is used for:

Treating non-Hodgkin lymphoma. It is used in combination with rituximab and 2 radioactive materials (In-111 and Y-90).

Ibritumomab is a monoclonal antibody protein. It works by binding to the cells that are involved in non-Hodgkin lymphoma. It is used along with 2 different radioactive materials. The first radioactive material (In-111) is attached to confirm that the cells are being reached. The second radioactive material (Y-90) is attached and damages the cells In-111 Zevalin binds to, which helps to reduce the number of abnormal cells involved in non-Hodgkin lymphoma.

Do NOT use In-111 Zevalin if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using In-111 Zevalin :

Some medical conditions may interact with In-111 Zevalin . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with In-111 Zevalin . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if In-111 Zevalin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use In-111 Zevalin :

Use In-111 Zevalin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use In-111 Zevalin .

Important safety information:

Possible side effects of In-111 Zevalin :

All medicines may cause side effects, but many people have no, or minor, side effects.

Anxiety; constipation; diarrhea; dizziness; flushing; headache; indigestion; joint or muscle pain; loss of appetite; nausea; runny nose; stomach pain or upset; sweating; throat irritation; trouble sleeping; vomiting; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); back pain; black, bloody, or dark stools; chest pain; cough; fainting; fast or irregular heartbeat; lightheadedness; numbness of an arm or leg; pain, burning, swelling, or redness at the injection site; persistent or severe diarrhea; red, swollen, blistered, or peeling skin; severe stomach pain or swelling; severe tiredness or weakness; shortness of breath; signs of infection (fever, chills, persistent sore throat); sudden, severe or persistent headache; swelling of the hands, feet, or legs; unusual bruising or bleeding; unusual vaginal bleeding; vision problems; vomit that looks like coffee grounds; yellowing of the eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

In-111 Zevalin is usually handled and stored by a health care provider. If you are using In-111 Zevalin at home, store In-111 Zevalin as directed by your pharmacist or health care provider. Keep In-111 Zevalin out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about In-111 Zevalin . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More In-111 Zevalin resources

Compare In-111 Zevalin with other medications for the treatment of:

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Campath

Posted by admin on November 2nd, 2009

Campath

Serious infections, blood disorders, and infusion reactions have occurred from the use of Campath . You will be closely monitored during the infusion and it may be necessary to stop treatment if an infusion reaction occurs. Notify your doctor immediately if you experience rigid muscles, fever, shortness of breath, tightness in the throat, fainting, chest pain, chills, or rash.

Campath is used for:

Treating B cell chronic lymphocytic leukemia (CLL). It may also be used for other conditions as determined by your doctor.

Campath is a monoclonal antibody. It works by recognizing certain proteins that are found on the surface of certain types of cancer cells. Once the proteins are recognized, the body’s immune system can kill the cancer cells.

Do NOT use Campath if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Campath :

Some medical conditions may interact with Campath . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Campath . However, no specific interactions with Campath are known at this time.

Ask your health care provider if Campath may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Campath :

Use Campath as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Campath .

Important safety information:

Possible side effects of Campath :

All medicines may cause side effects, but many people have no, or minor, side effects.

Abnormal skin sensations; back pain; bone pain; constipation; cough; depression; dizziness; general body discomfort; increased sweating; indigestion; loss of appetite; muscle pain; nosebleed; runny nose; sensation of temperature change; sleeplessness; stomach pain; tiredness; tremor; weakness; weight loss.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; blood in urine; bronchitis; chest pain; decreased hearing; diarrhea; extreme tiredness; fainting; fast or irregular heartbeat; fever; headache; hoarseness; itching; lightheadedness upon sitting or standing up; nausea; painful or difficult urination; pale skin; pneumonia; rapid weight gain; rigid muscles; shortness of breath; sores or ulcers on the lips or mouth; sudden sweating; swelling of the legs or feet; unusual bruising or bleeding; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Campath in the refrigerator, between 36 and 46 degrees F (2 and 8 degrees C). Do not freeze. Discard if vial has been frozen. Keep Campath out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Campath . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Campath resources

Compare Campath with other medications for the treatment of:

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Bexxar

Posted by admin on November 2nd, 2009

Bexxar

Bexxar may cause serious allergic reactions, especially in patients who have received murine proteins previously. Seek immediate medical attention if you experience rash, itching, swelling, severe dizziness, or trouble breathing. Bexxar may cause serious (possibly life-threatening) reductions in the number of white blood cells and platelets your body produces. This effect may last for an extended length of time. Additional treatment may be needed to manage this effect. Serious infections or bleeding could occur as a result of low blood cell levels. Contact your doctor immediately if you experience fever, persistent sore throat, any other sign of infection, or unusual bruising or bleeding. Bexxar must not be used during pregnancy because fetal harm can result. Contact your doctor immediately if you suspect that you could be pregnant.

What is Bexxar?

Bexxar is used to treat certain forms of non-Hodgkin lymphoma in patients who have not responded to other therapy.

Bexxar is a monoclonal antibody protein. It works by recognizing and sticking to a protein receptor on cancer cells and then killing the cancer cell.

Bexxar may also be used for other purposes not listed in this medication guide.

Do NOT use Bexxar if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Bexxar :

Some medical conditions may interact with Bexxar . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Bexxar . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Bexxar may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Bexxar :

Use Bexxar as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Bexxar .

Important safety information about Bexxar :

Possible side effects of Bexxar :

All medicines may cause side effects, but many people have no, or minor, side effects.

Constipation; diarrhea; dizziness; drowsiness; headache; muscle aches; nausea; pain, swelling, or redness at the injection site; stomach upset; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black stools; easy bruising or bleeding; fast heartbeat; flu-like symptoms such as chills, cough, or sweating; infection; itching; lightheadedness; loss of appetite; lung infection; new growths or lumps; pain, including chest, stomach, muscle, neck, back, or joint pain; pale skin; persistent sore throat or fever; shortness of breath; sudden weight loss; swelling of the hands or feet; unusual tiredness or weakness; vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions or need medical advice about side effects, contact your doctor or health care provider. You may report side effects to the FDA at 1-800-FDA-1088 (1-800-332-1088) or at www.fda.gov/medwatch.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center or emergency room immediately.

Bexxar is usually handled and stored by a health care professional. Keep Bexxar out of reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Bexxar . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Bexxar resources

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Vectibix

Posted by admin on November 2nd, 2009

Vectibix

Generic Name: panitumumab (pan i TUE moo mab)

What is Vectibix?

Vectibix is a cancer medication. It interferes with the growth of cancer cells by binding to a protein found on cancer cells which slows their growth and spread.

Vectibix is used to treat colon or rectal cancer that has spread to other parts of the body after treatment with other chemotherapy.

Vectibix may also be used for other purposes not listed in this guide.

Important information about Vectibix

Before receiving Vectibix, tell your doctor if you have any allergies or breathing problems. You may not be able to receive Vectibix, or you may need a dosage adjustment or special tests during treatment.

Vectibix may cause severe skin problems such as acne, itching, redness, skin rash, dryness, peeling, cracking, or oozing, and swelling or infection around your fingernails or toenails. Vectibix can also cause redness or irritation of your eyes or eyelids. More severe forms of skin problems can lead to widespread infection and possibly death. Seek emergency medical attention at the first sign of any skin rash.

Some people receiving a Vectibix injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, itchy, short of breath, or if you have a fever or chills during the injection.

The side effects of Vectibix may not appear when you first start using the medication. Severe skin or eye reactions may occur up to 2 weeks after the start of your treatment. These effects may not clear up for weeks or even months after you stop receiving Vectibix.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Vectibix can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

This medication may affect a woman’s fertility (ability to have children). You may also have irregular menstrual periods while receiving Vectibix.

Before receiving Vectibix

This medication may cause severe skin problems such as acne, itching, redness, skin rash, dryness, peeling, cracking, or oozing, and swelling or infection around your fingernails or toenails. More severe forms of skin problems can lead to widespread infection and possibly death. Seek emergency medical attention at the first sign of any skin rash. Do not use Vectibix if you are allergic to panitumumab.

Before receiving this medication, tell your doctor if you have any allergies or breathing problems. You may not be able to receive Vectibix, or you may need a dose adjustment or special tests to receive this medication.

FDA pregnancy category C. This medication may be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Vectibix passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

This medication may affect a woman’s fertility (ability to have children). You may also have irregular menstrual periods while receiving Vectibix.

How is Vectibix given?

Vectibix is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 90 minutes to complete.

Before you receive this medication, you may need to undergo a biopsy to make sure Vectibix is the right medication to treat your cancer.

Vectibix is usually given once every 2 weeks. Follow your doctor’s instructions.

What happens if I miss a dose?

Contact your doctor if you miss an appointment for your Vectibix injection.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine. Symptoms of a Vectibix overdose are unknown.

What should I avoid while taking Vectibix?

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds). Vectibix can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Vectibix side effects

Some people receiving a Vectibix injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, itchy, short of breath, or if you have a fever or chills during the injection.

Some of the side effects of Vectibix may not appear when you first start using the medication. Severe skin or eye reactions may occur up to 2 weeks after the start of your treatment. These effects may not clear up for weeks or even months after you stop receiving Vectibix.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

swelling of your hands or ankles;

acne, dryness, peeling, cracking, bleeding, oozing, pus, or any other sign of skin infection;

cough or wheezing, running out of breath easily;

white patches or sores inside your mouth or on your lips;

drowsiness, restless feeling, confusion, muscle stiffness, fast or uneven heart rate, chest pain;

redness, swelling, or irritation of your eyes or eyelids; or

swelling or infection around your fingernails or toenails.

Less serious Vectibix side effects may include:

nausea, vomiting, stomach pain;

diarrhea or constipation; or

tired feeling.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Vectibix?

There may be other drugs not listed that can affect Vectibix. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Erbitux

Posted by admin on November 2nd, 2009

Erbitux

Generic Name: cetuximab (se TUX i mab)

What is Erbitux?

Erbitux is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Erbitux is used to treat cancers of the colon and rectum. It is also used to treat head and neck cancer. It may be used alone or along with radiation treatments or other medicines.

Erbitux may also be used for other purposes not listed here.

Important information about Erbitux

You should not use Erbitux if you are allergic to cetuximab or to mouse protein.

Before receiving Erbitux, tell your doctor if you have heart rhythm problems, congestive heart failure, breathing problems, or coronary artery disease. Tell your doctor if you are also being treated with cisplatin (Platinol).

After you receive this medicine, your doctor will need to watch you for about an hour. This is to make sure you do not have any serious side effects from the medicine.

Some people receiving a Erbitux injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel short of breath, weak or dizzy, nauseated, itchy, or have wheezing, noisy breathing, or a hoarse voice during the injection.

To be sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested on a regular basis. It is important that you not miss any scheduled visits to your doctor. You may need to have blood tests for several weeks after your Erbitux treatment has ended.

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds) while you are receiving Erbitux and for at least 2 months after your treatment ends. Erbitux can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Before receiving Erbitux

You should not use Erbitux if you are allergic to cetuximab or to mouse protein.

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use Erbitux:

heart rhythm problems;

lung disease or a breathing disorder;

congestive heart failure; or

coronary artery disease (clogged arteries).

FDA pregnancy category C. It is not known whether Erbitux is harmful to an unborn baby. Before you receive this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. Whether you are a man or a woman, use effective birth control to prevent pregnancy while you are receiving Erbitux, and for at least 6 months after your treatment ends. You should not breast-feed a baby while you are receiving Erbitux and for at least 60 days after your treatment ends.

How is Erbitux given?

Erbitux is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion pump, and can take up to 2 hours to complete.

After your Erbitux infusion, your doctor will need to watch you for about an hour. This is to make sure you do not have any serious side effects from the medicine.

If you are also being treated with radiation, you will receive Erbitux one week before your radiation treatment.

To be sure this medication is helping your condition and not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. It is important that you not miss any scheduled visits to your doctor.

You may need to have blood tests for several weeks after your Erbitux treatment has ended.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Erbitux infusion.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine. Symptoms of a Erbitux overdose are not known.

What should I avoid while receiving Erbitux?

Avoid exposure to sunlight or artificial UV rays (sunlamps or tanning beds) while you are receiving Erbitux and for at least 2 months after your treatment ends. Erbitux can make your skin more sensitive to sunlight and sunburn may result. Use a sunscreen (minimum SPF 15) and wear protective clothing if you must be out in the sun.

Erbitux side effects

Some people receiving a Erbitux injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel short of breath, weak or dizzy, nauseated, itchy, or have wheezing, noisy breathing, or a hoarse voice during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

an acne-like skin rash or any severe skin rash;

slow heart rate, weak pulse, fainting, slow breathing (breathing may stop);

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

fever, chills, body aches, flu symptoms;

easy bruising or bleeding;

urinating more or less than usual;

hot dry skin with weakness or dizziness;

confusion; or

white patches or sores inside your mouth or on your lips.

Less serious Erbitux side effects may include:

dry, cracked, or swollen skin;

changes in your fingernails or toenails;

headache;

nausea, vomiting, stomach pain, loss of appetite;

diarrhea, constipation;

dry mouth, trouble swallowing;

cough or sore throat;

weight loss; or

weakness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Erbitux?

Tell your doctor if you are also being treated with cisplatin (Platinol).

There may be other drugs that can interact with Erbitux. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Rituxan

Posted by admin on November 2nd, 2009

Rituxan

Generic Name: rituximab (ri TUK si mab)

What is Rituxan?

Rituxan (rituximab) is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body.

Rituxan is used in combination with other cancer medicines to treat non-Hodgkin’s lymphoma. It is also used in combination with another drug called methotrexate to treat symptoms of adult rheumatoid arthritis.

Rituxan may also be used for purposes other than those listed here.

Important information about Rituxan

Do not receive Rituxan if you have ever had a severe allergic reaction to rituximab, or if you are allergic to mouse protein.

Some people receiving a Rituxan injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, weak, nauseated, light-headed, itchy, or if you have a fever, chills, muscle pain, sneezing, sore throat, trouble breathing, or pain in your chest or shoulders. Infusion reactions often occur within the first 24 hours after the start of your Rituxan infusion.

To be sure Rituxan is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.

If you have hepatitis B you may develop liver symptoms after you stop using Rituxan, even months after stopping. Your doctor may want to check your liver function at regular visits for several months after you stop using Rituxan. Do not miss any scheduled visits.

Rituxan increases the risk of a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have symptoms such as change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

Before receiving Rituxan

Do not receive Rituxan if you have ever had a severe allergic reaction to rituximab, or if you are allergic to mouse protein.

Before receiving Rituxan, tell your doctor if you are allergic to any drugs, or if you have:

liver disease or hepatitis B (or if you are a carrier of hepatitis B);

kidney disease;

systemic lupus erythematosus (SLE);

lung disease or a breathing disorder;

a history of heart disease, angina (chest pain), or heart rhythm disorder; or

a recent or active infection, including herpes, shingles, cytomegalovirus, or any infection that keeps coming back or does not clear up.

If you have any of these conditions, you may not be able to use Rituxan, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. It is not known whether Rituxan is harmful to an unborn baby. Before you receive this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether rituximab passes into breast milk or if it could harm a nursing baby. Do not take Rituxan without telling your doctor if you are breast feeding a baby.

Older adults may be more likely to have side effects from Rituxan, causing breathing difficulty or heart rhythm problems.

How is Rituxan given?

Rituxan is given as an injection through a needle placed into a vein. The medicine must be given slowly through an IV infusion. You will receive this injection in a clinic or hospital setting.

Before you receive Rituxan, you may be given other medications to prevent certain side effects that rituximab can cause.

Rituxan is usually given once per week for 4 to 8 weeks. In the treatment of rheumatoid arthritis, you may receive only two injections of this medicine, with 2 weeks in between treatments.

If you take any medications for high blood pressure, your doctor may ask you not to take them within 12 hours before you receive Rituxan. This is to prevent your blood pressure from getting too low during your Rituxan infusion. Follow your doctor’s instructions.

To be sure Rituxan is not causing harmful effects, your blood will need to be tested on a regular basis. Your kidney or liver function may also need to be tested. Do not miss any scheduled appointments.

If you have hepatitis B you may develop liver symptoms after you stop using Rituxan, even months after stopping. Your doctor may want to check your liver function at regular visits for several months after you stop using Rituxan. Do not miss any scheduled visits.

If you need to have any type of surgery, tell the surgeon ahead of time that you are being treated with Rituxan.

What happens if I miss a dose?

Call your doctor if you miss an appointment for your Rituxan injection.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine. Symptoms of a Rituxan overdose are not known.

What should I avoid while receiving Rituxan?

Do not receive a “live” vaccine while you are being treated with Rituxan.

Rituxan side effects

Some people receiving a Rituxan injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, weak, nauseated, light-headed, itchy, or if you have a fever, chills, muscle pain, sneezing, sore throat, trouble breathing, or pain in your chest or shoulders. Infusion reactions often occur within the first 24 hours after the start of your Rituxan infusion.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Rituxan increases the risk of a serious viral infection of the brain that can lead to disability or death. This risk is higher if you have a weak immune system or are receiving certain medicines. Call your doctor right away if you have symptoms such as change in your mental state, problems with speech or walking, or decreased vision. These symptoms may start gradually and get worse quickly.

Call your doctor at once if you have any of these serious side effects, even if they occur several months after you receive Rituxan, or after your treatment ends.

sudden numbness or weakness, especially on one side of the body;

confusion, dizziness, loss of balance, blurred vision, and problems with speech or walking; or

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

uneven heartbeats, wheezing or trouble breathing;

urinating more or less than usual;

fever, chills, cough, body aches, flu symptoms;

easy bruising or bleeding;

a red, raised, blistering, scaly, itchy, or peeling skin rash;

severe constipation or stomach pain;

black, bloody, or tarry stools; or

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious Rituxan side effects may include:

pain where the IV needle is placed;

headache, back pain;

mild stomach pain, nausea, or diarrhea;

swelling in your hands or feet;

muscle or joint pain;

runny or stuffy nose; or

night sweats.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rituxan?

Before receiving Rituxan, tell your doctor if you are also being treated with any of the following drugs:

cisplatin (Platinol);

adalimumab (Humira);

auranofin (Ridaura);

azathioprine (Imuran);

cyclosporine (Gengraf, Neoral, Sandimmune);

etanercept (Enbrel);

infliximab (Remicade);

leflunomide (Arava);

minocycline (Dynacin, Minocin, Vectrin);

sulfasalazine (Azulfidine);

blood pressure medications; or

medication to treat malaria, such as chloroquine (Aralen) or hydroxychloroquine (Plaquenil, Quineprox).

This is not a complete list and there may be other drugs that can affect Rituxan. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Avastin

Posted by admin on November 2nd, 2009

Avastin

Generic Name: bevacizumab (bev a CIZ oo mab)

What is Avastin?

Avastin is a cancer medicine that interferes with the growth of cancer cells by blocking the formation and growth of new blood vessels in the tumor which slows their growth.

Avastin is used to treat a certain type of brain tumor as well as cancers of the kidney, colon, rectum, lung, or breast. It is usually given as part of a combination of cancer medicines.

Avastin may also be used for purposes other than those listed here.

Important information Avastin

Avoid having surgery while you are being treated with Avastin. You may have problems with wound healing, which could result in bleeding or infection.

If you need to have any type of surgery, you will need to stop receiving Avastin for at least 4 weeks while your surgical incision heals.

Before being treated with Avastin, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, a history of stroke or blood clots, or an open wound.

Some people receiving a Avastin injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, chills, wheezing, or chest pain during the injection.

Call your doctor at once if you have serious side effects such as blood in your stools or vomit, sudden numbness or weakness (especially on one side of the body), sudden headache or confusion, problems with vision or speech, chest pain spreading to the arm or shoulder, shortness of breath, swelling, rapid weight gain, or flu symptoms.

Avastin can cause a rare but serious neurologic disorder affecting the brain. Symptoms include headache, confusion, vision problems, feeling light-headed, fainting, and seizure (blackout or convulsions). These rare symptoms may occur within hours of your first dose of Avastin, or they may not appear for up to a year after your treatment started. Call your doctor at once if you have any of these side effects.

To be sure Avastin is not causing harmful effects, your blood pressure will need to be tested on a regular basis. Your urine may also need to be tested. Do not miss any scheduled visits to your doctor.

Avastin can affect a woman’s fertility (ability to have children). Talk to your doctor about your specific risks.

Before using Avastin

Treatment with Avastin may cause you to have problems with wound healing, which could result in bleeding or infection. Before receiving Avastin, tell your doctor if you have had any type of surgery within the past 4 weeks. You may need to wait until your incision is completely healed before you are treated with Avastin.

If you have certain conditions, you may need a dose adjustment or special tests to safely use Avastin. Before this medicine, tell your doctor if you have:/p>

heart disease or high blood pressure;

a history of stroke or blood clots;

if you have an open wound; or

if you are receiving chemotherapy or medications to prevent anemia (lack of red blood cells).

If you have any of these conditions, you may not be able to use Avastin, or you may need a dosage adjustment or special tests during treatment.

FDA pregnancy category C. It is not known whether Avastin is harmful to an unborn baby. Before receiving this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether bevacizumab passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. Older adults may be more likely to have side effects from Avastin.

Avastin can affect a woman’s fertility (ability to have children). Talk to your doctor about your specific risks.

How is Avastin used?

Avastin is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take up to 90 minutes to complete.

Avastin is usually given once every 2 weeks.

To be sure this medication is not causing harmful effects, your blood pressure will need to be tested on a regular basis. Your urine may also need to be tested. Do not miss any scheduled visits to your doctor.

Avastin must be stored in a refrigerator and kept from freezing. Avastin bottles should never be shaken.

What happens if I miss a dose?

Contact your doctor if you miss an appointment to receive your Avastin infusion.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine. An overdose of Avastin may cause a severe headache.

What should I avoid while using Avastin?

Avoid having surgery while you are being treated with Avastin. You could have problems with wound healing, which may result in bleeding or infection.

If you need to have any type of surgery, you will need to stop receiving Avastin for at least 4 weeks while your surgical incision heals.

Avastin side effects

Avastin can cause a rare but serious neurologic disorder affecting the brain. Symptoms include headache, confusion, vision problems, feeling light-headed, fainting, and seizure (blackout or convulsions). These rare symptoms may occur within hours of your first dose of Avastin, or they may not appear for up to a year after your treatment started. Call your doctor at once if you have any of these side effects.

Some people receiving a Avastin injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you feel dizzy, nauseated, light-headed, sweaty, itchy, or have a fast heartbeat, chills, wheezing, or chest pain during the injection.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

stomach pain with vomiting or constipation;

black, bloody, or tarry stools;

vomit that looks like blood or coffee grounds;

sudden numbness or weakness, especially on one side of the body;

sudden headache, confusion, problems with vision, speech, or balance;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

increased blood pressure (severe headache, blurred vision, trouble concentrating, chest pain, numbness, seizure);

feeling short of breath, even with mild exertion;

swelling or rapid weight gain;

feeling like you might pass out;

urinating less than usual or not at all;

fever, chills, body aches, flu symptoms;

unusual bleeding such as nosebleeds, bleeding gums, or any bleeding that will not stop; or

white patches or sores inside your mouth or on your lips.

Less serious Avastin side effects may include:

diarrhea, stomach pain, loss of appetite;

dry mouth, increased thirst;

dizziness; or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Avastin?

There may be other drugs that can interact with Avastin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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