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Archive for the ‘alkylating agents’ Category

Zanosar

Posted by admin on November 2nd, 2009

Zanosar

Zanosar may cause severe, sometimes fatal kidney problems. The risk may be greater with higher doses. It may also cause liver problems, blood problems, diarrhea, and severe nausea and vomiting. It has also caused tumors and cancer in rodents.

Zanosar is used for:

Treating a certain type of pancreas cancer. It may also be used for other conditions as determined by your doctor.

Zanosar is an antineoplastic. It works by stopping or slowing the spread of certain cancer cells.

Do NOT use Zanosar if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Zanosar :

Some medical conditions may interact with Zanosar . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Zanosar . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Zanosar may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Zanosar :

Use Zanosar as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Zanosar .

Important safety information:

Possible side effects of Zanosar :

All medicines may cause side effects, but many people have no, or minor, side effects.

Diarrhea; nausea; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); change in the amount of urine produced; confusion; dark urine; depression; fever, chills, or sore throat; inability to urinate; mental or mood changes; pain, redness, or swelling at the injection site; severe nausea or vomiting; sudden unexplained weight gain; unusual bruising or bleeding; unusual weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Zanosar is usually handled and stored by a health care provider. If you are using Zanosar at home, store Zanosar as directed by your pharmacist or health care provider. Keep Zanosar , as well as needles and syringes, out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Zanosar . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Zanosar resources

Compare Zanosar with other medications for the treatment of:

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Treanda

Posted by admin on November 2nd, 2009

Treanda

Generic Name: bendamustine (BEN da MUS teen)

What is Treanda?

Treanda is a cancer medication that interferes with the growth of cancer cells and slows their growth and spread in the body. It is classified as an alkylating agent and works by blocking the growth of cancer cells.

Treanda is used to treat chronic lymphocytic leukemia. Treanda is also used to treat indolent B-cell non-Hodgkin lymphoma after other medications have been tried without successful treatment of this condition.

Treanda may also be used for other purposes not listed in this medication guide.

Important information about Treanda

You should not receive Treanda if you are allergic to bendamustine or mannitol (Osmitrol).

Before you receive Treanda, tell your doctor if you have a weak immune system, fever or other signs of infection, a metabolic disorder or electrolyte imbalance, liver or kidney disease, or if you smoke.

Tell your doctor about all other medications you use, especially carbamazepine (Carbatrol, Equetro, Tegretal), cimetidine (Tagamet), ciprofloxacin (Cipro), fluvoxamine (Luvox), omeprazole (Prilosec), thiabendazole (Mintezol), or a barbiturate such as phenobarbital (Solfoton) and others.

Do not use Treanda without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. Tell your caregiver right away if you have a fever, chills, itching, or skin rash during or shortly after the injection.

Other serious side effects to tell your doctor about include fever, chills, cough, sore throat, feeling short of breath, pale skin, easy bruising or bleeding, severe skin rash or itching, vomiting, diarrhea, pain, urinating less than usual, weak pulse, muscle weakness or stiffness, confusion, hallucinations, or white patches or sores inside your mouth or on your lips.

To be sure Treanda is not causing harmful effects, your blood may need to be tested on a regular basis. Your blood pressure may also need to be checked. Do not miss any scheduled appointments.

Before I receive Treanda

You should not receive Treanda if you are allergic to bendamustine or mannitol (Osmitrol).

If you have certain conditions, you may need a dose adjustment or special tests to safely use this medication. Before you receive Treanda, tell your doctor if you have:

a weak immune system;

fever or other signs of infection;

a metabolic disorder or electrolyte imbalance;

if you smoke.

FDA pregnancy category D. Treanda can cause harm to an unborn baby. Before you receive Treanda, tell your doctor if you are pregnant. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether Treanda passes into breast milk or if it could harm a nursing baby. Do not receive this medication without telling your doctor if you are breast-feeding a baby.

Some people receiving Treanda have developed certain types of cancers. It is not known whether this medication causes cancer. Talk with your doctor about the risks and benefits of using Treanda.

How is Treanda given?

Treanda is given as an injection through a needle placed into a vein. You will receive this injection in a clinic or hospital setting. The medicine must be given slowly through an IV infusion, and can take at least 30 minutes to complete.

Treanda is usually given for 2 days in a row every 21 to 28 days. You may receive up to 8 treatments total, depending on the condition being treated. Follow your doctor’s instructions.

You may be given other medications to help prevent certain side effects of Treanda.

To be sure this medication is not causing harmful effects, your blood may need to be tested on a regular basis. Your blood pressure may also need to be checked. Do not miss any scheduled appointments.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Treanda injection.

What happens if I overdose?

Seek emergency medical attention if you think you have received too much of this medicine.

Overdose symptoms may include drowsiness, tremors, slow or shallow breathing, loss of balance or coordination, or seizure (convulsions).

What should I avoid while receiving Treanda?

Treanda can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Treanda side effects

Some people receiving a Treanda injection have had a reaction to the infusion (when the medicine is injected into the vein). Tell your caregiver right away if you have fever, chills, itching, or skin rash during or shortly after the injection. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Tell your caregivers at once if you have a serious side effect such as:

fever, chills, body aches, flu symptoms;

cough with yellow or green mucus, stabbing chest pain, feeling short of breath;

pale skin, easy bruising or bleeding, extreme weakness;

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

the first sign of any skin rash, no matter how mild;

nausea, vomiting, diarrhea, loss of appetite, lower back pain, urinating less than ususal;

slow heart rate, weak pulse, muscle weakness or stiffness;

confusion, hallucinations; or

white patches or sores inside your mouth or on your lips.

Less serious Treanda side effects may include:

mild nausea, vomiting, constipation;

dry mouth, decreased sensation of taste;

drowsiness, tired feeling;

headache;

weight loss; or

pain, itching, swelling or other irritation around the IV needle.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Treanda?

Tell your doctor about all other medications you use, especially:

carbamazepine (Carbatrol, Equetro, Tegretal);

cimetidine (Tagamet);

ciprofloxacin (Cipro);

fluvoxamine (Luvox);

omeprazole (Prilosec);

thiabendazole (Mintezol); or

a barbiturate such as amobarbital (Amytal), butabarbital (Butisol), mephobarbital (Mebaral), secobarbital (Seconal), or phenobarbital (Solfoton).

This list is not complete and there may be other drugs that can interact with Treanda. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

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Thioplex

Posted by admin on November 2nd, 2009

Thioplex

Generic Name: thiotepa (THYE oh TEP a)

What is Thioplex (thiotepa)?

Thiotepa is a cancer (antineoplastic) medication. Thiotepa interferes with the growth of cancer cells and slows their growth and spread in the body.

Thiotepa is used in the treatment of cancers of the breast, ovary, bladder, and others.

Thiotepa may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Thioplex (thiotepa)?

Thiotepa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of thiotepa including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); severe heart damage with prolonged use; decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; fever or chills; or signs of infection); severe nausea, vomiting, diarrhea, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with thiotepa.

What should I discuss with my healthcare provider before using Thioplex (thiotepa)?

Do not use thiotepa without first talking to your doctor if you have

poor bone marrow function.

The use of thiotepa may be dangerous if you have any of the conditions listed above.

Thiotepa is in the FDA pregnancy category D. This means that thiotepa is known to be harmful to an unborn baby. Do not use thiotepa without first talking to your doctor if you are pregnant. Discuss with your doctor the appropriate use of birth control during treatment with thiotepa if either you or your partner is of childbearing potential. It is not known whether thiotepa passes into breast milk. Do not take thiotepa without first talking to your doctor if you are breast-feeding a baby. The safety and effectiveness of thiotepa in children has not been established.

How should I use Thioplex (thiotepa)?

Thiotepa should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with thiotepa depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with thiotepa to monitor progress and side effects.

Skin accidentally exposed to thiotepa should be rinsed thoroughly with soap and warm water.

Your healthcare provider will store thiotepa as directed by the manufacturer. If you are storing thiotepa at home, follow the directions provided by your healthcare provider.

What happens if I miss a dose?

Contact your doctor if you miss a dose of thiotepa.

What happens if I overdose?

If for any reason an overdose of thiotepa is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Symptoms of a thiotepa overdose tend to be similar to side effects caused by the medication, although often more severe.

What should I avoid while using Thioplex (thiotepa)?

Thiotepa can lower the activity of your immune system making you susceptible to infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with thiotepa. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.

Skin accidentally exposed to thiotepa should be rinsed thoroughly with soap and warm water.

Thioplex (thiotepa) side effects

If you experience any of the following serious side effects from thiotepa, seek emergency medical attention or contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);

tissue or vein reactions near the site of administration;

liver damage (abdominal pain, yellowing of the skin or eyes);

severe nausea, vomiting, or loss of appetite;

fever, chills, or other signs of infection; or

painful or difficult urination.

Other, less serious side effects may be more likely to occur. Continue taking thiotepa and talk to your doctor if you experience:

fatigue or weakness;

mild to moderate nausea, vomiting, or loss of appetite;

redness or inflammation of the eyes;

dizziness, headache, or blurred vision;

temporary hair loss;

a loss of skin coloration; or

decreased menstruation in women and decreased sperm production in men.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Thioplex (thiotepa)?

Do not receive “live” vaccines during treatment with thiotepa. Administration of a live vaccine may be dangerous during treatment with thiotepa.

Drugs other than those listed here may also interact with thiotepa. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with thiotepa.

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Temodar

Posted by admin on November 2nd, 2009

Temodar

Generic Name: temozolomide (oral) (TEM oh ZOE loe mide)

What is Temodar?

Temodar (temozolomide) interferes with the development of cancer cells, slowing their growth and spread in the body.

Temodar is used together with radiation therapy to treat certain types of brain tumor in adults. It works by stopping cancer cells from growing and reproducing.

Temodar is sometimes given after other cancer medications have been tried without successful treatment of the tumor.

Important information about Temodar

Do not Temodar if you are allergic to temozolomide or to another cancer medication called dacarbazine (DTIC-Dome). Before taking Temodar, tell your doctor if you have liver or kidney disease.

Do not use this medication without telling your doctor if you are pregnant. It could cause harm to the unborn baby. Use an effective form of birth control, and tell your doctor if you become pregnant during treatment. Do not open the Temodar capsule, or use a capsule that has been accidentally broken. The powder inside the capsule can be dangerous if you accidentally inhale it or if it gets in your eyes, mouth, or nose, or on your skin. If you must handle a broken capsule, ask your doctor or pharmacist how to safely handle and dispose of it. Rinse off any medicine that gets on your skin or in your eyes, nose, or mouth.

Temodar is often given together with radiation treatment, and then continued for several weeks or months after radiation treatment ends. There may be periods of time when you will take Temodar for only a few days in a row and then wait another 2 to 4 weeks before you start a new treatment cycle and take it again. Follow your doctor’s instructions carefully.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. The size, color, and number of Temodar capsules you take may be different from time to time as your doctor adjusts your dose. Be sure you know the correct number of capsules to take and on which days to take them. Contact your doctor or pharmacist if you have any questions.

Taking Temodar may increase your risk of developing certain types of bone marrow cancer. Talk with your doctor about your individual risk.

Before taking Temodar

You should not take Temodar if you are allergic to temozolomide or to another cancer medication called dacarbazine (DTIC-Dome).

If you have any of these other conditions, you may need a dose adjustment or special tests to safely use this medication:

FDA pregnancy category D. Temodar can cause harm to an unborn baby. Do not use this medication without telling your doctor if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether temozolomide passes into breast milk or if it could harm a nursing baby. Do not use Temodar without telling your doctor if you are breast-feeding a baby.

Taking Temodar may increase your risk of developing certain types of bone marrow cancer. Talk with your doctor about your individual risk.

Women and older adults may be more likely to have bone marrow suppression (a weakened immune system) while taking Temodar. This can lead to an increased risk of infection or illness.

How should I take Temodar?

Take Temodar exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Take Temodar on an empty stomach, at least 1 hour before or 2 hours after a meal. Swallow the capsule whole, with a full glass of water.

If you vomit shortly after taking Temodar, do not take another capsule until it is time for your next regularly scheduled dose.

Do not open the Temodar capsule, or use a capsule that has been accidentally broken. The powder inside the capsule can be dangerous if you accidentally inhale it or if it gets in your eyes, mouth, or nose, or on your skin. If you must handle a broken capsule, ask your doctor or pharmacist how to safely handle and dispose of it. Rinse off any medicine that gets on your skin or in your eyes, nose, or mouth.

You may be given other medications to prevent infection while you are taking Temodar. Use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor.

Temodar can lower blood cells that help your body fight infections. This can make it easier for you to bleed from an injury or get sick from being around others who are ill. To be sure your blood cells do not get too low, your blood will need to be tested on a regular basis. Do not miss any scheduled appointments.

Contact your doctor at once if you develop signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, mouth sores, or unusual weakness.

Temodar is often given together with radiation treatment, and then continued for several weeks or months after radiation treatment ends. There may be periods of time when you will take Temodar for only a few days in a row and then wait another 2 to 4 weeks before you start a new treatment cycle and take it again. Follow your doctor’s instructions carefully.

Your doctor may occasionally change your dose to make sure you get the best results from this medication. The size, color, and number of Temodar capsules you take may be different from time to time as your doctor adjusts your dose. Be sure you know the correct number of capsules to take and on which days to take them. Contact your doctor or pharmacist if you have any questions.

Store Temodar at room temperature away from moisture and heat.

What happens if I miss a dose?

Contact your doctor if you miss a dose or forget to take your medicine dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Taking Temodar for more than 5 days in a row can cause life-threatening overdose.

Overdose symptoms may include fever, pale skin, increased thirst, dry skin, easy bruising or bleeding, confusion, weakness, and urinating less than usual or not at all.

What should I avoid while taking Temodar?

Avoid being near people who have colds, the flu, or other contagious illnesses. Contact your doctor at once if you develop signs of infection.

Temodar side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Temodar: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

seizure (convulsions);

numbness or tingling on one side of your body;

signs of infection such as fever, chills, sore throat, flu symptoms, easy bruising or bleeding (nosebleeds, bleeding gums), loss of appetite, nausea and vomiting, unusual weakness;

dry cough, feeling short of breath, weight loss, night sweats;

pain or burning when you urinate; or

white patches or sores inside your mouth or on your lips.

Less serious Temodar side effects may include:

hair loss;

tired feeling;

diarrhea, constipation;

mild skin rash;

dizziness, blurred vision;

sleep problems (insomnia); or

unusual or unpleasant taste in your mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Temodar?

Before taking Temodar, tell your doctor if you are using any of the following drugs:

carbamazepine (Carbatrol, Tegretol);

divalproex sodium (Depakote);

phenytoin (Dilantin);

valproic acid (Depakene, Depacon);

steroids (prednisone and others); or

a sulfa drug such as Bactrim, Septra, Cotrim, or SMX-TMP.

This list is not complete and there may be other drugs that can interact with Temodar. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

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Platinol-AQ

Posted by admin on November 2nd, 2009

Platinol AQ

Platinol AQ can cause severe kidney problems or allergic reactions. Hearing loss (more common in children), bleeding problems, a decrease in your body’s ability to fight infection (weakened immune system), or severe nausea and vomiting may also occur. The risk of these problems increases as the dose or total amount of Platinol AQ used over time increases. Notify your doctor immediately if you develop changes in the amount of urine, rash, trouble breathing, swelling of the face, fast heartbeat, dizziness, ringing in the ears or hearing loss, unusual bruising or bleeding, nausea and vomiting, unusual tiredness, or signs of an infection (eg, fever, persistent sore throat).

Platinol AQ is used for:

Treating cancer of the testes, ovaries, or bladder. Platinol AQ may be used alone or in combination with other medications. It may also be used for other conditions as determined by your doctor.

Platinol AQ is an antineoplastic agent. It works by stopping cancer cells from growing and reproducing.

Do NOT use Platinol AQ if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Platinol AQ :

Some medical conditions may interact with Platinol AQ . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Platinol AQ . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Platinol AQ may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Platinol AQ :

Use Platinol AQ as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Platinol AQ .

Important safety information:

Possible side effects of Platinol AQ :

All medicines may cause side effects, but many people have no, or minor, side effects.

Diarrhea; loss of appetite; muscle pain; nausea; vomiting; weakness.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blindness; blood in the urine or stools; blurred vision; chest pain; decreased urine volume or frequency; dizziness; hearing problems; inability to distinguish colors; infection (fever, chills, sore throat, cough); joint pain; lightheadedness; loss of balance; loss of motor function; loss of taste; numbness, tingling, or pain of the hands or feet; pain, redness, or swelling at the site of injection; ringing in the ears; seizures; unusual bruising or bleeding; unusual tiredness; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Platinol AQ as directed on the prescription label. Platinol AQ is usually handled and stored by a health care provider. If you are using Platinol AQ at home, store Platinol AQ as directed by your pharmacist or health care provider. Keep Platinol AQ out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Platinol AQ . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Platinol AQ resources

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Platinol

Posted by admin on November 2nd, 2009

Platinol

Generic Name: cisplatin (sis PLA tin)

What is Platinol (cisplatin)?

Cisplatin is an antineoplastic medication. Cisplatin interferes with the growth of cancer cells and slows their growth and spread in the body.

Cisplatin is used to treat various types of cancer including metastatic testicular tumors, metastatic ovarian tumors, and advanced bladder cancer.

Cisplatin may also be used for purposes other than those listed in this medication guide.

What is the most important information I should know about Platinol (cisplatin)?

Cisplatin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of cisplatin including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); kidney damage (little or no urine production, blood in the urine); hearing loss or ringing in the ears; decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection); severe nausea, vomiting, diarrhea, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with cisplatin.

Who should not use Platinol (cisplatin)?

Do not use cisplatin without first talking to your doctor if you have

poor bone marrow function;

hearing impairment; or

an allergy to platinum or platinum-containing products.

The use of cisplatin may be dangerous if you have any of the conditions listed above.

Cisplatin is in the FDA pregnancy category D. This means that cisplatin is known to be harmful to an unborn baby. Do not use cisplatin without first talking to your doctor if you are pregnant. Discuss with your doctor the appropriate use of birth control during treatment with cisplatin if necessary. Cisplatin passes into breast milk and may harm a nursing baby. Breast-feeding should be avoided during treatment with cisplatin.

How should I use Platinol (cisplatin)?

Cisplatin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with cisplatin depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Adequate hydration is important during treatment with cisplatin. Your doctor may prescribe the administration of intravenous fluids and/or recommend additional fluid intake by mouth during treatment.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with cisplatin to monitor progress and side effects.

Your healthcare provider will store cisplatin as directed by the manufacturer. If you are storing cisplatin at home, follow the directions provided by your healthcare provider.

What happens if I miss a dose?

Contact your doctor if you miss a dose of cisplatin.

What happens if I overdose?

If for any reason an overdose of cisplatin is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Symptoms of a cisplatin overdose tend to be similar to side effects caused by the medication, although often more severe.

What should I avoid while using Platinol (cisplatin)?

There are no restrictions on food, beverages, or activity while using cisplatin unless otherwise directed by your doctor.

Platinol (cisplatin) side effects

If you experience all of the following serious side effects from cisplatin, contact your doctor immediately:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

kidney damage (little or no urine production, blood in the urine);

hearing loss or ringing in the ears;

decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);

severe nausea, vomiting, diarrhea, and loss of appetite;

heart and circulation problems;

gout or increased uric acid in the blood;

numbness or tingling;

blurred vision, altered color perception, blindness, and other visual problems;

liver damage (abdominal pain, yellowing of the skin or eyes); or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Platinol (cisplatin)?

Before using cisplatin, tell your doctor if you are using any of the following medicines to control seizures:

carbamazepine (Tegretol, Carbatrol, Epitol);

phenytoin (Dilantin);

gabapentin (Neurontin);

tiagabine (Gabitril);

valproic acid (Depakene) or divalproex sodium (Depakote);

lamotrigine (Lamictal);

felbamate (Felbatol);

levetiracetam (Keppra);

primidone (Mysoline);

zonisamide (Zonegran);

topiramate (Topamax);

oxcarbazepine (Trileptal);

a barbiturate such as mephobarbital (Mebaral) or pentobarbital (Nembutal); or

a benzodiazepine such as lorazepam (Ativan), diazepam (Diastat, Valium), clonazepam (Klonopin), or clorazepate (Tranxene).

Cisplatin may decrease the effects of medicines used to control seizures and a dosage adjustment may be required.

Drugs other than those listed here may also interact with cisplatin. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including herbal products, during treatment with cisplatin.

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Paraplatin

Posted by admin on November 2nd, 2009

Paraplatin

Generic Name: carboplatin (car bo PLAH tin)

What is Paraplatin?

Paraplatin is an antineoplastic medication. It interferes with the growth of cancer cells and slows their growth and spread in the body.

Paraplatin is used to treat ovarian cancer and many other types of cancer.

Paraplatin may also be used for purposes other than those listed in this medication guide.

Important information about Paraplatin

Paraplatin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Serious side effects have been reported with the use of Paraplatin including: allergic reactions (difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives); kidney damage (little or no urine production, blood in the urine); hearing loss or ringing in the ears; decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection); severe nausea, vomiting, diarrhea, and loss of appetite; and others. Talk to your doctor about the possible side effects from treatment with Paraplatin.

Before using Paraplatin

Do not use Paraplatin without first talking to your doctor if you have:

a bleeding problem;

poor bone marrow function;

hearing impairment; or

an allergy to platinum, platinum-containing products, or mannitol.

The use of Paraplatin may be dangerous if you have any of the conditions listed above.

Paraplatin is in the FDA pregnancy category D. This means that carboplatin is known to be harmful to an unborn baby. Do not use Paraplatin without first talking to your doctor if you are pregnant or could become pregnant during treatment. Discuss with your doctor the appropriate use of birth control during treatment with Paraplatin if necessary. It is not known whether carboplatin passes into breast milk. Breast-feeding should be avoided during treatment with this medication.

How should I use Paraplatin?

Paraplatin should only be administered under the supervision of a qualified healthcare provider experienced in the use of cancer chemotherapeutic agents.

Your doctor will determine the correct amount and frequency of treatment with Paraplatin depending upon the type of cancer being treated and other factors. Talk to your doctor if you have any questions or concerns regarding the treatment schedule.

Adequate hydration is important during treatment with Paraplatin. Your doctor may prescribe the administration of intravenous fluids and/or recommend additional fluid intake by mouth during treatment.

Your doctor will probably want you to have regularly scheduled blood tests and other medical evaluations during treatment with carboplatin to monitor progress and side effects.

Your healthcare provider will store Paraplatin as directed by the manufacturer. If you are storing Paraplatin at home, follow the directions provided by your healthcare provider.

What happens if I miss a dose?

Contact your doctor if you miss a dose of this medication.

What happens if I overdose?

If for any reason an overdose of Paraplatin is suspected, seek emergency medical attention or contact your healthcare provider immediately.

Symptoms of a Paraplatin overdose tend to be similar to side effects caused by the medication, although often more severe.

What should I avoid while using Paraplatin?

Paraplatin can lower the activity of your immune system making you susceptible to infections. Avoid contact with people who have colds, the flu, or other contagious illnesses and do not receive vaccines that contain live strains of a virus (e.g., live oral polio vaccine) during treatment with Paraplatin. In addition, avoid contact with individuals who have recently been vaccinated with a live vaccine. There is a chance that the virus can be passed on to you.

Paraplatin side effects

If you experience any of the following serious side effects from Paraplatin, contact your doctor immediately or seek emergency medical attention:

an allergic reaction (including difficulty breathing; closing of the throat; swelling of the lips, tongue, or face; or hives);

kidney damage (little or no urine production, blood in the urine);

decreased bone marrow function and blood problems (extreme fatigue; easy bruising or bleeding; black, bloody or tarry stools; or fever, chills, or signs of infection);

severe nausea, vomiting, and loss of appetite; or

blurred vision, altered color perception, temporary blindness, and other visual problems.

Other, less serious Paraplatin side effects may be more likely to occur. Continue taking this medicine and talk to your doctor if you experience:

hearing loss or ringing in the ears;

numbness or tingling;

weakness;

mild to moderate nausea, vomiting, or loss of appetite; or

hair loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Paraplatin?

Do not receive “live” vaccines during treatment with Paraplatin. Administration of a live vaccine may be dangerous during treatment with this medicine.

Other medications may interact with Paraplatin. Talk to your doctor and pharmacist before taking any other prescription or over-the-counter medicines, including vitamins, minerals, and herbal products, during treatment with Paraplatin.

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Myleran

Posted by admin on November 2nd, 2009

Myleran

Myleran may cause severe bone marrow depression, which can reduce the body’s ability to fight infection or cancer. Lab tests will be required to monitor therapy. Myleran may also increase the risk of developing a second cancer.

Myleran is used for:

Treating the symptoms of chronic myelogenous leukemia.

Myleran is an alkylating agent. It works by slowing down reproduction and growth of certain white blood cells, which helps the body fight leukemia.

Do NOT use Myleran if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Myleran :

Some medical conditions may interact with Myleran . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Myleran . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Myleran may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Myleran :

Use Myleran as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Myleran .

Important safety information:

Possible side effects of Myleran :

All medicines may cause side effects, but many people have no, or minor, side effects.

Darkening of the skin; diarrhea; dizziness; dry mouth, nose, and throat.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abrupt weakness; chest pain; confusion; congestion; decreased ability to fight infection; fever, chills, or sore throat; infertility; loss of appetite; missed menstrual period; nausea; persistent cough; seizures; shortness of breath; stomach or joint pain; unusual bruising or bleeding; unusual tiredness or fatigue; vision changes; vomiting; weight loss; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Myleran at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Myleran out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Myleran . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Myleran resources

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Mustargen

Posted by admin on November 2nd, 2009

Mustargen

Mustargen should only be used under the supervision of a doctor experienced in the use of anticancer agents. Do not inhale the dust and vapors of Mustargen . Avoid direct contact on skin, nose, mouth, or eyes. Mustargen is very damaging to surrounding tissue if it accidentally leaks. Notify your doctor immediately if you develop signs of leakage: pain, swelling, peeling, and hardening of the skin around the injection site. Ice may be applied for 6 to 12 hours and a special medicine (sodium thiosulfate) may be used if leakage occurs.

Mustargen is used for:

Treating certain types of cancer. It may also be used for other conditions as determined by your doctor.

Mustargen is an alkylating agent. It works by stopping the production of proteins necessary for cell growth and reproduction.

Do NOT use Mustargen if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Mustargen :

Some medical conditions may interact with Mustargen . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Mustargen . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Mustargen may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Mustargen :

Use Mustargen as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Mustargen .

Important safety information:

Possible side effects of Mustargen :

All medicines may cause side effects, but many people have no, or minor, side effects.

Diarrhea; dizziness; loss of appetite; nausea; skin rash; vomiting.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bleeding from the gums; cough; difficulty swallowing; fever or chills; irregular or absent menstrual periods; pain, redness, or swelling at the injection site; sore throat; sores on the mouth or lips; swelling of hands/ankles; unusual bruising or bleeding.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Mustargen is usually handled and stored by a health care provider. If you are using Mustargen at home, store Mustargen as directed by your pharmacist or health care provider. Keep Mustargen out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Mustargen . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Mustargen resources

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Ifex

Posted by admin on November 2nd, 2009

Ifex Solution

Ifex Solution should only be used under the supervision of a doctor experienced with the use of cancer medicines. Bladder effects (eg, bleeding, inflammation) or central nervous system effects (eg, confusion, coma) may occur with use of Ifex Solution. Contact your doctor immediately if you experience any of these symptoms. Ifex Solution may also cause bone marrow depression.

Ifex Solution is used for:

Treating certain types of cancer in combination with other medicines. It is also usually used along with a medicine called mesna, which decreases the risk of bleeding in the bladder.

Ifex Solution is an antineoplastic. It works by stopping the growth of certain cancers.

Do NOT use Ifex Solution if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Ifex Solution:

Some medical conditions may interact with Ifex Solution. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Ifex Solution. Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Ifex Solution may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Ifex Solution:

Use Ifex Solution as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Ifex Solution.

Important safety information:

Possible side effects of Ifex Solution:

All medicines may cause side effects, but many people have no, or minor, side effects.

Hair loss; loss of appetite; nausea.

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); abdominal pain; blood in the urine; confusion; cough; dizziness; fever or chills; hallucinations; irregular or absent menstrual periods; joint pain; mood changes; painful or frequent urination; shortness of breath; sleepiness; sore throat; sores on the mouth or lips; unusual bruising or bleeding; unusual fatigue; vomiting; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Powder for injection should be stored at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store away from heat, moisture, and light. After solution has been properly mixed, it may be stored at room temperature for 7 days or refrigerated between 36 and 46 degrees F (2 and 8 degrees C) for up to 21 days. Do not store Ifex Solution in the bathroom. Keep Ifex Solution, as well as needles and syringes, out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Ifex Solution. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Ifex Solution resources

Compare Ifex Solution with other medications for the treatment of:

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