Archive for the ‘anti-infectives’ Category

RibaTab

RibaTab

Generic Name: ribavirin (oral) (rye ba VYE rin)

What is ribavirin?

Ribavirin is an antiviral medication.

Ribavirin must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C.

Ribavirin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ribavirin?

Ribavirin is not effective when used alone to treat hepatitis C. Ribavirin must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C. This medication can cause birth defects or death in an unborn baby.

If you are a woman, do not take ribavirin if you are pregnant.

If you are a man, do not take ribavirin if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin.

Use at least two effective forms of birth control while either sexual partner is taking ribavirin, and for at least 6 months after treatment ends.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking ribavirin.

Ribavirin may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.

What should I discuss with my healthcare provider before taking ribavirin?

You should not take this medication if you are allergic to ribavirin, or if you have:

severe liver disease;

autoimmune hepatitis;

a hemoglobin disorder such as anemia, thalassemia (Mediterranean anemia), or sickle-cell anemia; or

if you are pregnant woman, or a man whose female sexual partner is pregnant.

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before using ribavirin, tell your doctor if you have:

hepatitis B infection;

a blood cell disorder;

cancer;

psoriasis;

diabetes;

sarcoidosis;

a thyroid disorder;

hepatitis B virus or human immunodeficiency virus (HIV or AIDS);

a history of heart disease, high blood pressure, or a heart attack;

a history of depression or suicide attempt;

a history of drug or alcohol addiction; or

a history of a liver or other organ transplant.

Tell your doctor if you have been treated with interferon in the past and it did not work well in treating your hepatitis C.

If you are a woman, do not take ribavirin if you are pregnant. You will need frequent pregnancy tests to make sure you are not pregnant while taking ribavirin.

If you are a man, do not take ribavirin if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin. Your sexual partner will need frequent pregnancy tests to make sure she is not pregnant while you are taking ribavirin.

Use at least two effective forms of birth control while either sexual partner is taking ribavirin, and for at least 6 months after treatment ends.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking ribavirin.

Your name may need to be listed on a ribavirin pregnancy registry if you become pregnant while you or your male sexual partner are taking this medication or during the 6 months after treatment ends. The purpose of this registry is to track the outcome of the pregnancy and delivery to evaluate whether ribavirin had any effect on the baby.

It is not known whether ribavirin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take ribavirin?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Ribavirin is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C. Take this medicine with food.

Measure the liquid form of ribavirin with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Ribavirin may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your liver and thyroid function may also need to be checked. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.

It is important to use ribavirin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. You may need to take this medication for many months.

Drink extra fluids while you are taking ribavirin to keep from getting dehydrated, especially during exercise or in hot weather.

Ribavirin can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking ribavirin, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.

Store ribavirin tablets and capsules at room temperature away from moisture, heat, and light. Store ribavirin liquid (oral solution) in the refrigerator. Do not allow it to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. If you have not taken the medication for longer than 24 hours, call your doctor for instructions. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include easy bruising or bleeding, urinating less than usual or not at all, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, or a general ill feeling.

What should I avoid while taking ribavirin?

Treatment with ribavirin does not prevent spread of the hepatitis C virus to other people. Follow your doctor’s instructions about how to prevent passing the disease to another person.

Do not drink alcohol while taking ribavirin. Alcohol can increase the risk of damage to your liver. Ribavirin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Ribavirin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using ribavirin and call your doctor at once if you have any of these serious side effects:

pale or yellowed skin, dark colored urine, easy bruising or bleeding, confusion, or unusual weakness;

severe depression, hallucinations, thoughts of suicide or hurting yourself;

fever, chills, body aches, flu symptoms, trouble breathing;

severe blistering, peeling, and red skin rash;

blood diarrhea, or black tarry stools;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or

severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

Less serious side effects may include:

feeling tired or irritable;

dry mouth, cough;

headache, dizziness;

hearing or vision problems;

hair loss, dry skin, rash, itching;

joint or muscle pain; or

sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ribavirin?

Before taking ribavirin, tell your doctor if you are using any of the following drugs:

abacavir (Ziagen);

didanosine (Videx);

lamivudine (Combivir, Epivir, Epzicom, Trizivir);

stavudine (Zerit);

tenofovir (Viread);

zalcitabine (Hivid); or

zidovudine (Retrovir, AZT).

This list is not complete and there may be other drugs that can interact with ribavirin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Ribasphere

Ribasphere

The U.S. Food and Drug Administration (FDA) has granted marketing approval for Ribasphere (Ribavirin capsules) 200mg in combination with interferon alfa-2b for the treatment of Hepatitis C (?

RibaPak

RibaPak

Generic Name: ribavirin (oral) (rye ba VYE rin)

What is ribavirin?

Ribavirin is an antiviral medication.

Ribavirin must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C.

Ribavirin may also be used for other purposes not listed in this medication guide.

What is the most important information I should know about ribavirin?

Ribavirin is not effective when used alone to treat hepatitis C. Ribavirin must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C. This medication can cause birth defects or death in an unborn baby.

If you are a woman, do not take ribavirin if you are pregnant.

If you are a man, do not take ribavirin if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin.

Use at least two effective forms of birth control while either sexual partner is taking ribavirin, and for at least 6 months after treatment ends.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking ribavirin.

Ribavirin may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.

What should I discuss with my healthcare provider before taking ribavirin?

You should not take this medication if you are allergic to ribavirin, or if you have:

severe liver disease;

autoimmune hepatitis;

a hemoglobin disorder such as anemia, thalassemia (Mediterranean anemia), or sickle-cell anemia; or

if you are pregnant woman, or a man whose female sexual partner is pregnant.

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before using ribavirin, tell your doctor if you have:

hepatitis B infection;

a blood cell disorder;

cancer;

psoriasis;

diabetes;

sarcoidosis;

a thyroid disorder;

hepatitis B virus or human immunodeficiency virus (HIV or AIDS);

a history of heart disease, high blood pressure, or a heart attack;

a history of depression or suicide attempt;

a history of drug or alcohol addiction; or

a history of a liver or other organ transplant.

Tell your doctor if you have been treated with interferon in the past and it did not work well in treating your hepatitis C.

If you are a woman, do not take ribavirin if you are pregnant. You will need frequent pregnancy tests to make sure you are not pregnant while taking ribavirin.

If you are a man, do not take ribavirin if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking ribavirin. Your sexual partner will need frequent pregnancy tests to make sure she is not pregnant while you are taking ribavirin.

Use at least two effective forms of birth control while either sexual partner is taking ribavirin, and for at least 6 months after treatment ends.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking ribavirin.

Your name may need to be listed on a ribavirin pregnancy registry if you become pregnant while you or your male sexual partner are taking this medication or during the 6 months after treatment ends. The purpose of this registry is to track the outcome of the pregnancy and delivery to evaluate whether ribavirin had any effect on the baby.

It is not known whether ribavirin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take ribavirin?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Ribavirin is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C. Take this medicine with food.

Measure the liquid form of ribavirin with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Ribavirin may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your liver and thyroid function may also need to be checked. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.

It is important to use ribavirin regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. You may need to take this medication for many months.

Drink extra fluids while you are taking ribavirin to keep from getting dehydrated, especially during exercise or in hot weather.

Ribavirin can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking ribavirin, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.

Store ribavirin tablets and capsules at room temperature away from moisture, heat, and light. Store ribavirin liquid (oral solution) in the refrigerator. Do not allow it to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. If you have not taken the medication for longer than 24 hours, call your doctor for instructions. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include easy bruising or bleeding, urinating less than usual or not at all, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, or a general ill feeling.

What should I avoid while taking ribavirin?

Treatment with ribavirin does not prevent spread of the hepatitis C virus to other people. Follow your doctor’s instructions about how to prevent passing the disease to another person.

Do not drink alcohol while taking ribavirin. Alcohol can increase the risk of damage to your liver. Ribavirin can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Ribavirin side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using ribavirin and call your doctor at once if you have any of these serious side effects:

pale or yellowed skin, dark colored urine, easy bruising or bleeding, confusion, or unusual weakness;

severe depression, hallucinations, thoughts of suicide or hurting yourself;

fever, chills, body aches, flu symptoms, trouble breathing;

severe blistering, peeling, and red skin rash;

blood diarrhea, or black tarry stools;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or

severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

Less serious side effects may include:

feeling tired or irritable;

dry mouth, cough;

headache, dizziness;

hearing or vision problems;

hair loss, dry skin, rash, itching;

joint or muscle pain; or

sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect ribavirin?

Before taking ribavirin, tell your doctor if you are using any of the following drugs:

abacavir (Ziagen);

didanosine (Videx);

lamivudine (Combivir, Epivir, Epzicom, Trizivir);

stavudine (Zerit);

tenofovir (Viread);

zalcitabine (Hivid); or

zidovudine (Retrovir, AZT).

This list is not complete and there may be other drugs that can interact with ribavirin. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Rebetol

Rebetol

Generic Name: ribavirin (oral) (rye ba VYE rin)

What is Rebetol?

Rebetol is an antiviral medication.

Rebetol must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C.

Rebetol may also be used for other purposes not listed in this medication guide.

Important information about Rebetol

Rebetol is not effective when used alone to treat hepatitis C. Rebetol must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C. This medication can cause birth defects or death in an unborn baby.

If you are a woman, do not take Rebetol if you are pregnant.

If you are a man, do not take Rebetol if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking Rebetol.

Use at least two effective forms of birth control while either sexual partner is taking this medication, and for at least 6 months after treatment ends.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking Rebetol.

Rebetol may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.

Before taking Rebetol

You should not take Rebetol if you are allergic to ribavirin, or if you have:

severe liver disease;

autoimmune hepatitis;

a hemoglobin disorder such as anemia, thalassemia (Mediterranean anemia), or sickle-cell anemia; or

if you are pregnant woman, or a man whose female sexual partner is pregnant.

If you have certain conditions, you may need a dose adjustment or special tests to safely take Rebetol. Before using this medication, tell your doctor if you have:

hepatitis B infection;

a blood cell disorder;

cancer;

psoriasis;

diabetes;

sarcoidosis;

a thyroid disorder;

hepatitis B virus or human immunodeficiency virus (HIV or AIDS);

a history of heart disease, high blood pressure, or a heart attack;

a history of depression or suicide attempt;

a history of drug or alcohol addiction; or

a history of a liver or other organ transplant.

Tell your doctor if you have been treated with interferon in the past and it did not work well in treating your hepatitis C.

This medication can cause birth defects or death in an unborn baby.

If you are a woman, do not take Rebetol if you are pregnant. You will need frequent pregnancy tests to make sure you are not pregnant while taking this medicine.

If you are a man, do not take Rebetol if your female sexual partner is pregnant. An unborn baby could also be harmed if a man fathers the child while he is taking this medicine. Your sexual partner will need frequent pregnancy tests to make sure she is not pregnant while you are taking Rebetol.

Use at least two effective forms of birth control while either sexual partner is taking Rebetol, and for at least 6 months after treatment ends.

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking this medicine.

Your name may need to be listed on a Rebetol pregnancy registry if you become pregnant while you or your male sexual partner are taking this medication or during the 6 months after treatment ends. The purpose of this registry is to track the outcome of the pregnancy and delivery to evaluate whether Rebetol had any effect on the baby.

It is not known whether ribavirin passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take Rebetol?

Take Rebetol exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Rebetol is not effective when used alone to treat hepatitis C. It must be used together with an interferon alfa product (such as Peg-Intron or Intron A) to treat chronic hepatitis C. Take this medicine with food.

Measure the liquid form of Rebetol with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Rebetol may decrease the number of red blood cells in your body. This is called anemia and it can be life-threatening in people who have heart disease or circulation problems. To be sure this medication is not causing harmful effects, your blood will need to be tested on a regular basis. Your liver and thyroid function may also need to be checked. Do not miss any scheduled visits to your doctor.

Call your doctor at once if you have pale or yellowed skin, dark colored urine, fever, confusion, chest pain, shortness of breath, or weakness. These may be signs of serious anemia.

It is important to use Rebetol regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely. You may need to take this medication for many months.

Drink extra fluids while you are taking Rebetol to keep from getting dehydrated, especially during exercise or in hot weather.

Rebetol can cause dry mouth, which could lead to tooth decay or gum disease. If you vomit while taking Rebetol, rinse your mouth out with water to prevent damage to your teeth or gums. Be sure to have regular dental exams while you are taking this medication.

Store ribavirin tablets and capsules at room temperature away from moisture, heat, and light. Store ribavirin liquid (oral solution) in the refrigerator. Do not allow it to freeze.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at your next regularly scheduled time. If you have not taken the medication for longer than 24 hours, call your doctor for instructions. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Overdose symptoms may include easy bruising or bleeding, urinating less than usual or not at all, chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, or a general ill feeling.

What should I avoid while taking Rebetol?

Treatment with Rebetol does not prevent spread of the hepatitis C virus to other people. Follow your doctor’s instructions about how to prevent passing the disease to another person.

Do not drink alcohol while taking Rebetol. Alcohol can increase the risk of damage to your liver. Rebetol can cause side effects that may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.

Rebetol side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Rebetol and call your doctor at once if you have any of these serious side effects:

pale or yellowed skin, dark colored urine, easy bruising or bleeding, confusion, or unusual weakness;

severe depression, hallucinations, thoughts of suicide or hurting yourself;

fever, chills, body aches, flu symptoms, trouble breathing;

severe blistering, peeling, and red skin rash;

blood diarrhea, or black tarry stools;

chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling; or

severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate.

Less serious Rebetol side effects may include:

feeling tired or irritable;

dry mouth, cough;

headache, dizziness;

hearing or vision problems;

hair loss, dry skin, rash, itching;

joint or muscle pain; or

sleep problems (insomnia).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Rebetol?

Before taking Rebetol, tell your doctor if you are using any of the following drugs:

abacavir (Ziagen);

didanosine (Videx);

lamivudine (Combivir, Epivir, Epzicom, Trizivir);

stavudine (Zerit);

tenofovir (Viread);

zalcitabine (Hivid); or

zidovudine (Retrovir, AZT).

This list is not complete and there may be other drugs that can interact with Rebetol. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Cytovene

Cytovene

Cytovene may cause low white blood cell levels, low platelet levels, and anemia. In animal studies, it caused cancer, low sperm production, and birth defects. Cytovene is used to treat cytomegalovirus (CMV) eye infection in patients with a weakened immune system. It is also used to prevent CMV infection in certain transplant patients. It is not approved for any other conditions.

Cytovene is used for:

Treating CMV eye infection in patients with a weakened immune system. It is used to prevent CMV infection in certain organ transplant patients. It may also be used for other conditions as determined by your doctor.

Cytovene is an antiviral agent. It works by blocking reproduction of the CMV virus.

Do NOT use Cytovene if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Cytovene :

Some medical conditions may interact with Cytovene . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Cytovene . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Cytovene may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Cytovene :

Use Cytovene as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Cytovene .

Important safety information:

Possible side effects of Cytovene :

All medicines may cause side effects, but many people have no, or minor, side effects.

Diarrhea; loss of appetite; sweating; vomiting.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); bloody or black, tarry stools; change in the amount of urine produced; confusion; fever, chills, or sore throat; numbness or tingling of hands or feet; pain, swelling, or redness at the injection site; severe or persistent stomach pain; unusual bleeding or bruising; unusual tiredness or weakness; vision changes (eg, blurred vision, flashes of light); vomit that looks like coffee grounds.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Cytovene is usually handled and stored by a health care provider. If you are using Cytovene at home, store Cytovene as directed by your pharmacist or health care provider. Keep Cytovene out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Cytovene . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Cytovene resources

Compare Cytovene with other medications for the treatment of:

Copegus

Copegus

Copegus may cause serious birth defects and/or fetal death when used during pregnancy. It should not be used by women who are pregnant or by men whose female partners are pregnant. Women of childbearing potential who either take Copegus or are sexual partners of men who take Copegus must:

At least 2 reliable forms of effective birth control must be used during treatment with Copegus and for 6 months after treatment with Copegus is stopped.

Use of Copegus alone is not effective for treating chronic hepatitis C infection. Copegus must be used with another medicine (interferon) in order to treat hepatitis C infection.

Copegus may cause serious blood problems (hemolytic anemia), which can cause serious and sometimes fatal heart attacks in patients who have heart disease. Do not take Copegus you have a history of serious or uncontrolled heart problems.

Copegus is used for:

Treating hepatitis C infection in certain patients when used in combination with peginterferon. It may also be used for other conditions as determined by your doctor.

Copegus is an antiviral medicine. How Copegus works to treat hepatitis C is not completely understood.

Do NOT use Copegus if:

Contact your doctor or health care provider right away if any of these apply to you.

Before using Copegus :

Some medical conditions may interact with Copegus . Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

Some MEDICINES MAY INTERACT with Copegus . Tell your health care provider if you are taking any other medicines, especially any of the following:

This may not be a complete list of all interactions that may occur. Ask your health care provider if Copegus may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Copegus :

Use Copegus as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Ask your health care provider any questions you may have about how to use Copegus .

Important safety information:

Possible side effects of Copegus :

All medicines may cause side effects, but many people have no, or minor, side effects.

Blurred vision; cough; diarrhea; dizziness; dry mouth; dry skin; hair loss; joint pain; loss of appetite; mild headache, nausea, or vomiting; tiredness; trouble sleeping; upset stomach; weakness or fatigue.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); black, tarry stools; changes in vision or speech; chest pain; confusion; dark urine; decrease in the amount of urine; depression; fever, chills, or sore throat; irregular heartbeat; memory problems; muscle pain or weakness; numbness or tingling of arms or legs; one-sided weakness; prolonged nausea and vomiting; rapid breathing; severe headache, dizziness, or vomiting; severe stomach or back pain; shortness of breath; sinus problems; thoughts of suicide; unusual bruising or bleeding; unusual mental or mood changes; unusual or severe tiredness and fatigue; vomit that looks like coffee grounds; weight loss; yellowing of eyes or skin.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center (

Store Copegus at 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 86 degrees F (15 and 30 degrees C) is permitted. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Copegus out of the reach of children and away from pets.

General information:

This information is a summary only. It does not contain all information about Copegus . If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

More Copegus resources

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Zovirax

Zovirax

Generic Name: acyclovir (oral) (a SY klo veer)

What is the most important information I should know about Zovirax?

Treatment with Zovirax should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Herpes infections are contagious and you can infect other people, even while you are being treated with Zovirax. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

What is Zovirax?

Zovirax is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Zovirax will not cure herpes, but it can lessen the symptoms of the infection.

Zovirax is used to treat infections caused by herpes viruses. Illnesses caused by herpes viruses include genital herpes, cold sores, shingles, and chicken pox.

Zovirax may also be used for purposes other than those listed in this medication guide.

What should I discuss with my healthcare provider before taking Zovirax?

Do not take this medicine if you are allergic to Zovirax or valacyclovir (Valtrex). Before taking Zovirax, tell your doctor if you are allergic to any drugs, or if you have kidney disease. You may need a dosage adjustment or special tests during treatment.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Herpes virus can be passed from an infected mother to her baby during childbirth. If you have genital herpes, it is very important to prevent herpes lesions during your pregnancy so that you do not have a genital lesion when your baby is born. Zovirax passes into breast milk and may harm a nursing infant. Do not take this medication without telling your doctor if you are breast-feeding a baby.

How should I take Zovirax?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Treatment with Zovirax should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Take each dose with a full glass of water. Drink plenty of water while you are taking Zovirax to keep your kidneys working properly.

Zovirax can be taken with or without food. Taking Zovirax with food may decrease stomach upset.

Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one. Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Zovirax will not treat a viral infection such as the common cold or flu.

Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions.

Store Zovirax at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include seizure (convulsions), hallucinations, and urinating less than usual or not at all.

What should I avoid while taking Zovirax?

Herpes infections are contagious and you can infect other people, even while you are being treated with Zovirax. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Zovirax will not prevent the spread of genital herpes. Avoid sexual intercourse or use a latex condom to prevent spreading the virus to others.

What are the possible side effects of Zovirax?

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have any of these serious side effects:

pain in your lower back;

urinating less than usual or not at all;

easy bruising or bleeding; or

unusual weakness.

Less serious side effects may include:

nausea, vomiting, diarrhea, loss of appetite, stomach pain;

headache, feeling light-headed; or

swelling in your hands or feet.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Zovirax?

Before taking Zovirax, tell your doctor if you are also taking probenecid (Benemid). If you are using probenecid, you may not be able to use Zovirax, or you may need dosage adjustments or special tests during treatment.

There may be other drugs that can affect Zovirax. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Famvir

Famvir

Generic Name: famciclovir (fam SYE klo veer)

What is Famvir?

Famvir is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Famvir will not cure herpes, but it can lessen the symptoms of the infections.

Famvir is used to treat infections caused by herpes viruses. Illnesses caused by herpes viruses include genital herpes, cold sores, shingles, and chicken pox.

Important information about Famvir

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated.

Treatment with Famvir should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Herpes infections are contagious and you can infect other people, even while you are being treated with Famvir. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Before taking Famvir

Do not take this medication if you are allergic to penciclovir (Denavir). Before taking this medication, tell your doctor if you have:

kidney disease;

galactose intolerance;

severe lactase deficiency; or

glucose-galactose malabsorption.

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Famvir.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. It is not known whether Famvir passes into breast milk, or if it could harm a nursing baby. Do not take this medication without telling your doctor if you are breast-feeding a baby. Do not give this medication to a child younger than 18 years old.

How should I take Famvir?

Take this medication exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor.

Treatment with Famvir should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Take each dose with a full glass of water. Drink plenty of water while you are taking this medication to keep your kidneys working properly.

Famvir can be taken with or without food. Taking Famvir with food may decrease stomach upset.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Famvir will not treat a viral infection such as the common cold or flu.

Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions.

Store this medication at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a Famvir overdose are unknown.

What should I avoid while taking Famvir?

Herpes infections are contagious and you can infect other people, even while you are being treated with Famvir. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Famvir will not prevent the spread of genital herpes. Avoid sexual intercourse or use a latex condom to prevent spreading the virus to others.

Famvir side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious side effects may include:

nausea, vomiting, stomach pain;

headache;

diarrhea,

dizziness, sleepiness;

mild itching or skin rash; or

confusion.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Famvir?

Before taking Famvir, tell your doctor if you are also taking probenecid (Benemid). If you are using probenecid, you may not be able to use Famvir, or you may need dosage adjustments or special tests during treatment.

This list is not complete and there may be other drugs that can interact with Famvir. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor.

Valtrex

Valtrex

Generic Name: valacyclovir (val a SYE kloe veer)

What is Valtrex?

Valtrex is an antiviral drug. It slows the growth and spread of the herpes virus so that the body can fight off the infection. Valtrex will not cure herpes, but it can lessen the symptoms of the infection.

Valtrex is used to treat infections caused by herpes viruses in adults and children. Illnesses caused by herpes viruses include genital herpes, cold sores, shingles, and chickenpox.

Valtrex is used to treat cold sores in children who are at least 12 years old, and to treat chickenpox in children who are at least 2 years old.

Valtrex may also be used for other purposes not listed in this medication guide.

Important information about Valtrex

Before taking Valtrex, tell your doctor if you have HIV/AIDS, a weak immune system, kidney disease (or if you are on dialysis), or if you have had a kidney or bone marrow transplant.

Valtrex can be harmful to the kidneys, and these effects are increased when it is used together with other medicines that can harm the kidneys. Tell your doctor about all other medications you are using. You may need dose adjustments or special tests when taking certain medications together with Valtrex.

Treatment with Valtrex should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters).

Herpes virus can be passed from an infected mother to her baby during childbirth. If you have genital herpes, it is very important to prevent herpes lesions during your pregnancy so that you do not have a genital lesion when your baby is born.

Valtrex will not prevent the spread of genital herpes. Herpes infections are contagious and you can infect other people even while you are taking with Valtrex.

Stop taking Valtrex and call your doctor right away if you have any signs of a serious side effect that can harm red blood cells, such as: fever, easy bruising or bleeding, red spots on the skin (not related to herpes or chickenpox), bloody diarrhea, vomiting, pale or yellowed skin, weakness, fainting, or urinating less than usual or not at all.

Do not give Valtrex to a child unless it has been prescribed by a doctor.

Before taking Valtrex

Do not take this medicine if you are allergic to valacyclovir or acyclovir (Zovirax).

If you have certain conditions, you may need a dose adjustment or special tests to safely take this medication. Before taking Valtrex, tell your doctor if you have:

HIV/AIDS, or other conditions that can weaken the immune system;

kidney disease (or if you are on dialysis); or

if you have had a kidney or bone marrow transplant.

How should I take Valtrex?

Take Valtrex exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

Treatment with Valtrex should be started as soon as possible after the first appearance of symptoms (such as tingling, burning, blisters). This medication might not be as effective if you first start taking it 1 or 2 days after the start of your symptoms.

Take each dose with a full glass of water. Drink plenty of water while you are taking Valtrex to keep your kidneys working properly. Shake the oral suspension (liquid) well just before you measure a dose. To be sure you get the correct dose, measure the liquid with a marked measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Valtrex can be taken with or without food.

Take this medication for the entire length of time prescribed by your doctor. Your symptoms may get better before the infection is completely treated. Valtrex will not treat a viral infection such as the common cold or flu.

Lesions caused by herpes viruses should be kept as clean and dry as possible. Wearing loose clothing may help to prevent irritation of the lesions.

Store Valtrex tablets at room temperature away from moisture and heat. Store Valtrex liquid in a refrigerator. Do not freeze. Throw away any unused Valtrex that is older than 28 days.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine.

Overdose symptoms may include urinating less than usual or not at all.

What should I avoid while taking Valtrex?

Valtrex will not prevent the spread of genital herpes. Herpes infections are contagious and you can infect other people even while you are taking with Valtrex.

Avoid sexual intercourse or use a latex condom to prevent spreading the virus to others. Avoid letting infected areas come into contact with other people. Avoid touching an infected area and then touching your eyes. Wash your hands frequently to prevent passing the infection to others.

Valtrex side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Valtrex and call your doctor right away if you have any of the following signs of a serious side effect that can harm red blood cells:

fever, easy bruising or bleeding;

red spots on the skin (not related to herpes or chickenpox);

bloody diarrhea, vomiting;

pale or yellowed skin;

weakness or fainting; or

urinating less than usual or not at all.

pain in your lower back;

drowsiness, mood changes, increased thirst, loss of appetite, nausea and vomiting;

swelling, weight gain, feeling short of breath;

confusion, agitation, aggression, hallucinations, trouble concentrating;

feeling shaky or unsteady;

problems with speech or vision; or

seizure (convulsions).

Less serious Valtrex side effects may include:

nausea, stomach pain;

headache, dizziness, tired feeling, depression;

joint pain;

menstrual pain;

mild skin rash; or

stuffy nose, sore throat.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Valtrex?

Valtrex can be harmful to the kidneys, and these effects are increased when it is used together with other medicines that can harm the kidneys. Before taking Valtrex, tell your doctor if you are also using:

lithium (Eskalith, Lithobid);

methotrexate (Rheumatrex, Trexal);

pain or arthritis medicines such as aspirin (Anacin, Excedrin), acetaminophen (Tylenol), diclofenac (Voltaren), etodolac (Lodine), ibuprofen (Advil, Motrin), indomethacin (Indocin), naproxen (Aleve, Naprosyn), and others;

medicines used to treat ulcerative colitis, such as mesalamine (Pentasa) or sulfasalazine (Azulfidine);

medicines used to prevent organ transplant rejection, such as sirolimus (Rapamune) or tacrolimus (Prograf);

IV antibiotics such as amphotericin B (Fungizone, AmBisome, Amphotec, Abelcet), amikacin (Amikin), bacitracin (Baci-IM), capreomycin (Capastat), gentamicin (Garamycin), kanamycin (Kantrex), streptomycin, or vancomycin (Vancocin, Vancoled);

antiviral medicines such as adefovir (Hepsera), cidofovir (Vistide), or foscarnet (Foscavir); or

cancer medicine such as aldesleukin (Proleukin), carmustine (BiCNU, Gliadel), cisplatin (Platinol), ifosfamide (Ifex), oxaliplatin (Eloxatin), plicamycin (Mithracin), streptozocin (Zanosar), or tretinoin (Vesanoid).

This list is not complete and there may be other drugs that can interact with Valtrex. Tell your doctor about all your prescription and over-the-counter medications, vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start a new medication without telling your doctor.

Invirase

Invirase

Generic Name: saquinavir (sa KWIN a veer)

What is Invirase?

Invirase is an antiviral medication. It is in a group of drugs called protease (PRO-tee-ayz) inhibitors. It prevents human immunodeficiency virus (HIV) cells from multiplying in your body.

Invirase is used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). This medication is not a cure for HIV or AIDS.

Invirase may also be used for other purposes not listed in this medication guide.

Important information about Invirase

Do not take Invirase with amiodarone (Cordarone, Pacerone), flecainide (Tambocor), propafenone (Rythmol), rifampin (Rifadin, Rimactane, Rifater), quinidine (Cardioquin, Quinaglute, Quinidex), cisapride (Propulsid), pimozide (Orap), midazolam (Versed), triazolam (Halcion), or an ergot medicine such as Ergomar, Cafergot, Wigraine, D.H.E. 45, Migranal or Methergine.

There are many other medicines that can interact with Invirase. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

Taking Invirase will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.

Before taking Invirase

Do not take this medication if you are allergic to saquinavir.

Do not take Invirase with any of the following medications. They can cause life-threatening side effects if you use them while you are taking Invirase:

amiodarone (Cordarone, Pacerone);

cisapride (Propulsid);

flecainide (Tambocor);

midazolam (Versed) or triazolam (Halcion);

pimozide (Orap);

propafenone (Rythmol);

quinidine (Cardioquin, Quinidex, Quinaglute); or

or ergot medicines such as ergotamine (Ergomar, Cafergot), dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), ergonovine (Ergotrate), or methylergonovine (Methergine).

If you have any of these conditions, you may need a dose adjustment or special tests to safely take Invirase:

diabetes;

a bleeding disorder (hemophilia); or

high cholesterol or triglycerides.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby, but HIV can be passed to the baby if the mother is not properly treated during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant during treatment. Take all of your HIV medicines as directed to control your infection while you are pregnant.

Your name may need to be listed on an antiviral pregnancy registry when you start using this medication.

Invirase can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while taking Invirase. You should not breast-feed while you are using Invirase. Women with HIV or AIDS should not breast-feed at all. Even if your baby is born without HIV, you may still pass the virus to the baby in your breast milk. Do not give this medication to a child younger than 16 years old without the advice of a doctor.

How should I take Invirase?

Take Invirase exactly as it was prescribed for you. Do not take the medication in larger amounts, or take it for longer than recommended by your doctor. Follow the directions on your prescription label.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Take each dose with a full glass (8 ounces) of water.

Invirase should be taken together with another medication called ritonavir (Norvir).

Take Invirase and ritonavir with food or within 2 hours after eating a full meal.

It is important to use Invirase regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of different drugs. To best treat your condition, use all of your medications as directed by your doctor. Be sure to read the medication guide or patient instructions provided with each of your medications. Do not change your doses or medication schedule without advice from your doctor. Every person with HIV or AIDS should remain under the care of a doctor.

To be sure Invirase is helping your condition, your blood will need to be tested on a regular basis. Your liver function may also need to be tested. Do not miss any scheduled appointments.

Store Invirase at room temperature away from moisture and heat.

What happens if I miss a dose?

Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and take the medicine at the next regularly scheduled time. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of a Invirase overdose are not known.

What should I avoid while taking Invirase?

If you also take didanosine, take it 2 hour before or after you take Invirase.

Taking Invirase will not prevent you from passing HIV to other people through unprotected sex or sharing of needles. Talk with your doctor about safe methods of preventing HIV transmission during sex, such as using a condom and spermicide. Sharing drug or medicine needles is never safe, even for a healthy person.

Invirase side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Invirase: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking Invirase and call your doctor at once if you have any of these serious side effects:

fever, sore throat, and headache with a severe blistering, peeling, and red skin rash;

increased urination or extreme thirst;

easy bruising or bleeding;

signs of a new infection, such as fever or chills, cough, or flu symptoms; or

nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Less serious Invirase side effects may include:

mild nausea, vomiting, diarrhea, stomach pain;

numbness or tingling, especially around your mouth;

muscle pain;

headache, mood changes; or

changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Invirase?

Many drugs can interact with Invirase. Below is just a partial list. Tell your doctor if you are using:

digoxin (digitalis, Lanoxin);

fluticasone (Advair, Flonase, Flovent);

garlic or St. John’s wort;

antibiotics such as clarithromycin (Biaxin), itraconazole (Sporanox), ketoconazole (Nizoral), or rifampin (Rifadin, Rimactane, Rifater);

antidepressants such as amitriptyline (Elavil, Etrafon), imipramine (Janimine, Tofranil), trazodone (Desyrel), and others;

a blood thinner such as warfarin (Coumadin);

a calcium channel blocker such as amlodipine (Caduet, Lotrel, Norvasc), diltiazem (Tiazac, Cartia, Dilacor), felodipine (Plendil), nifedipine (Procardia, Adalat), or verapamil (Calan, Covera, Isoptin, Verelan);

cholesterol-lowering medicine such as atorvastatin (Lipitor), lovastatin (Mevacor, Altocor), or simvastatin (Zocor);

drugs that weaken the immune system, such as cyclosporine (Gengraf, Neoral, Sandimmune), sirolimus (Rapamune), or tacrolimus (Prograf);

other HIV /AIDS medicine such as darunavir (Prezista), lopinavir/ritonavir (Kaletra), or tipranavir (Aptivus);

insulin or diabetes medication you take by mouth;

medicines to treat erectile dysfunction, such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra); or

seizure medications such as carbamazepine (Carbatrol, Tegretol), phenobarbital (Luminal, Solfoton), or phenytoin (Dilantin).

This list is not complete and there may be other medicines that can interact with Invirase. Tell your doctor about all the prescription and over-the-counter medications you use. This includes vitamins, minerals, herbal products, and drugs prescribed by other doctors. Do not start using a new medication without telling your doctor. Keep a list with you of all the medicines you use and show this list to any doctor or other healthcare provider who treats you.

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